STRN Antibody

Datasheet

Code	CSB-PA022880DSR1HU
Size	US$166
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Image	Western blot All lanes: STRN antibody at 3μg/ml + NIH/3T3 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 87, 81 kDa Observed band size: 87 kDa Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA022880DSR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA022880DSR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA022880DSR1HU at dilution of 1:100
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) STRN Polyclonal antibody

Uniprot No.

O43815

Target Names

STRN

Alternative Names

MGC125642 antibody; SG2NA antibody; Striatin antibody; Striatin Calmodulin binding protein antibody; STRN antibody; STRN_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Striatin protein (581-780AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling.

Gene References into Functions

striatin-associated Salt Sensitive Blood Pressure is associated with normal plasma renin activity and reduced epinephrine levels PMID: 28985281
The prevalence of STRN-ALK kinase fusions were determined in papillary thyroid cancer of an adult population PMID: 29046324
In this review, we summarize the current understanding of the assembly and functions of STRIPAK complexes( striatin-centered multicomponent supramolecular structures containing both kinases and phosphatases), with a special focus on cell signaling and cancer PMID: 26876214
we report 2 cases of renal cell carcinomas harboring a novel STRN-ALK fusion PMID: 26848800
the "multimodulator" scaffold roles of striatins in the initiation and regulation of the formation of various complex particles and structures, are discussed. PMID: 25501894
PP2A/striatin complex modulates microtubule dynamics by regulating MAP2 phosphorylation PMID: 25497017
the rapid, nongenomic mineralocorticoid receptor pathway (mediated via striatin) has a role in modulating the interaction between salt intake and blood pressure. PMID: 25368024
A recurrent STRN/ALK fusion found in thyroid carcinomas. PMID: 24475247
Our data demonstrate that STRN-ALK fusion occurs in a subset of patients with highly aggressive types of thyroid cancer and provide initial evidence suggesting that it may represent a therapeutic target for these patients. PMID: 24613930
Striatin orchestrates the regulation of Mst3 by PP2A. PMID: 21985334
identify striatin as a molecular scaffold required for rapid, nongenomic estrogen-mediated activation of downstream signaling pathways PMID: 15569929
Taken together, splicing variation of SG2NA might have some critical roles in differentiation and maturation in metazoan cells. PMID: 18571342
Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. PMID: 19165527

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Subcellular Location

Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, dendritic spine.

Protein Families

WD repeat striatin family

Tissue Specificity

Preferentially expressed in brain.

Database Links

HGNC: 11424

OMIM: 614765

KEGG: hsa:6801

STRING: 9606.ENSP00000263918

UniGene: Hs.127486

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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