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Recombinant Human T-cell surface glycoprotein CD1e, membrane-associated (CD1E)

Code CSB-YP004893HU
MSDS
MSDS Datasheet
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Source Yeast
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Code CSB-EP004893HU
MSDS
MSDS Datasheet
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Source E.coli
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Code CSB-EP004893HU-B
MSDS
MSDS Datasheet
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP004893HU
MSDS
MSDS Datasheet
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Source Baculovirus
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Code CSB-MP004893HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
CD1E
Uniprot No.
P15812
Alternative Names
T-cell surface glycoprotein CD1e, membrane-associated; hCD1e; R2G1; CD antigen CD1e; [Cleaved into: T-cell surface glycoprotein CD1e, soluble; sCD1e] CD1E
Species
Homo sapiens (Human)
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Protein FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Related Products

CD1E Antibodies

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Target Background

Function
T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.
Gene References into Functions
  1. There was no association between polymorphisms of CD1E genes and the susceptibilities to Guillain-Barre syndrome. PMID: 27653862
  2. The interaction of LAPTM5 with CD1e and their colocalization in antigen processing compartments both suggest that LAPTM5 might influence the role of CD1e in the presentation of lipid antigens. PMID: 22880058
  3. in the late endosomes/lysosomes of dendritic cells, the acid pH promotes the binding of lipid antigens to CD1e through increased hydrophobic and ionic interactions PMID: 21481186
  4. allelic variation in CD1E does not play a major role in determining multifocal motor neuropathy susceptibility. PMID: 22003931
  5. CD1e may positively or negatively affect lipid presentation by CD1b, CD1c, and CD1d. PMID: 21844346
  6. These data support that CD1e could have evolved to mediate lipid-exchange/editing processes. PMID: 21788486
  7. substitutions lead to amino acid changes at position 73 and 77 of the alpha1 domain in the former and at position 30 of the alpha2 domain in the latter suggesting that the CD1E gene is much more polymorphic than previously assumed. PMID: 12144626
  8. cellular and biochemical properties of the human and simian CD1e molecules are similar, suggesting that the particular intracellular distribution of CD1e is important for its physiological and/or immunological function PMID: 12671734
  9. required for processing of the mycobcterial antigens hexamannosylated phosphatidyl-myo-inositols(PIM6); propose that, through this form of glycolipid editing, CD1e helps expand the repertoire of glycolipidic T cell antigens to optimize immune response PMID: 16311334
  10. Data show that ubiquitination of CD1e appears to trigger its exit from Golgi compartments and its transport to endosomes. PMID: 18208508
  11. A polymorphism related to the capacity of the CD1E molecule to participate in the immune response to complex glycolipids is discovered in individuals who might display a CD1e-altered immune response to complex glycolipid antigens. PMID: 18325888
  12. CD1e propeptide is conserved during evolution, suggesting that it may also optimize the generation of CD1e molecules in other species. PMID: 19196239

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Subcellular Location
[T-cell surface glycoprotein CD1e, membrane-associated]: Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome. Late endosome. Note=Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells.; [T-cell surface glycoprotein CD1e, soluble]: Lysosome lumen.
Tissue Specificity
Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues.
Database Links

HGNC: 1638

OMIM: 188411

KEGG: hsa:913

STRING: 9606.ENSP00000357149

UniGene: Hs.249217

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