CD1E Antibody

1. There was no association between polymorphisms of CD1E genes and the susceptibilities to Guillain-Barre syndrome. PMID: 27653862
2. The interaction of LAPTM5 with CD1e and their colocalization in antigen processing compartments both suggest that LAPTM5 might influence the role of CD1e in the presentation of lipid antigens. PMID: 22880058
3. in the late endosomes/lysosomes of dendritic cells, the acid pH promotes the binding of lipid antigens to CD1e through increased hydrophobic and ionic interactions PMID: 21481186
4. allelic variation in CD1E does not play a major role in determining multifocal motor neuropathy susceptibility. PMID: 22003931
5. CD1e may positively or negatively affect lipid presentation by CD1b, CD1c, and CD1d. PMID: 21844346
6. These data support that CD1e could have evolved to mediate lipid-exchange/editing processes. PMID: 21788486
7. substitutions lead to amino acid changes at position 73 and 77 of the alpha1 domain in the former and at position 30 of the alpha2 domain in the latter suggesting that the CD1E gene is much more polymorphic than previously assumed. PMID: 12144626
8. cellular and biochemical properties of the human and simian CD1e molecules are similar, suggesting that the particular intracellular distribution of CD1e is important for its physiological and/or immunological function PMID: 12671734
9. required for processing of the mycobcterial antigens hexamannosylated phosphatidyl-myo-inositols(PIM6); propose that, through this form of glycolipid editing, CD1e helps expand the repertoire of glycolipidic T cell antigens to optimize immune response PMID: 16311334
10. Data show that ubiquitination of CD1e appears to trigger its exit from Golgi compartments and its transport to endosomes. PMID: 18208508
11. A polymorphism related to the capacity of the CD1E molecule to participate in the immune response to complex glycolipids is discovered in individuals who might display a CD1e-altered immune response to complex glycolipid antigens. PMID: 18325888
12. CD1e propeptide is conserved during evolution, suggesting that it may also optimize the generation of CD1e molecules in other species. PMID: 19196239

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HGNC: 1638

OMIM: 188411

KEGG: hsa:913

STRING: 9606.ENSP00000357149

UniGene: Hs.249217