Recombinant Human TBC1 domain family member 15(TBC1D15)

Code CSB-YP823452HU
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Source Yeast
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Code CSB-EP823452HU
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Source E.coli
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Code CSB-EP823452HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP823452HU
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Source Baculovirus
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Code CSB-MP823452HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names TBC1D15
Uniprot No. Q8TC07
Alternative Names DKFZp686M1379; DKFZp761D0223; FLJ12085; FLJ33191; GAP for RAB7; GTPase-activating protein RAB7; RAB7 GAP; Rab7-GAP; TBC1 domain family member 15; TBC15_HUMAN; Tbc1d15; Tre 2 budding uninhibited by benzimidazole cell division cycle 16 domain; domain family member 15; Tre2/Bub2/Cdc16 domain family member 15
Species Homo sapiens (Human)
Expression Region 2-691
Target Protein Sequence AAAGVVSGK IIYEQEGVYI HSSCGKTNDQ DGLISGILRV LEKDAEVIVD WRPLDDALDS SSILYARKDS SSVVEWTQAP KERGHRGSEH LNSYEAEWDM VNTVSFKRKP HTNGDAPSHR NGKSKWSFLF SLTDLKSIKQ NKEGMGWSYL VFCLKDDVVL PALHFHQGDS KLLIESLEKY VVLCESPQDK RTLLVNCQNK SLSQSFENLL DEPAYGLIQA GLLDRRKLLW AIHHWKKIKK DPYTATMIGF SKVTNYIFDS LRGSDPSTHQ RPPSEMADFL SDAIPGLKIN QQEEPGFEVI TRIDLGERPV VQRREPVSLE EWTKNIDSEG RILNVDNMKQ MIFRGGLSHA LRKQAWKFLL GYFPWDSTKE ERTQLQKQKT DEYFRMKLQW KSISQEQEKR NSRLRDYRSL IEKDVNRTDR TNKFYEGQDN PGLILLHDIL MTYCMYDFDL GYVQGMSDLL SPLLYVMENE VDAFWCFASY MDQMHQNFEE QMQGMKTQLI QLSTLLRLLD SGFCSYLESQ DSGYLYFCFR WLLIRFKREF SFLDILRLWE VMWTELPCTN FHLLLCCAIL ESEKQQIMEK HYGFNEILKH INELSMKIDV EDILCKAEAI SLQMVKCKEL PQAVCEILGL QGSEVTTPDS DVGEDENVVM TPCPTSAFQS NALPTLSASG ARNDSPTQIP VSSDVCRLTP A
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity).
Gene References into Functions
  1. Report provides evidence for a new function of TBC1D15 in the control of GLUT4 vesicles translocation through regulating Rab7 activity. Glucose uptake was greatly reduced when TBC1D15 was knocked out. PMID: 30316925
  2. Demonstrate that TBC1D15 and TBC1D17 mediate proper autophagic encapsulation of mitochondria by regulating Rab7 activity at the interface between mitochondria and isolation membranes. PMID: 24569479
  3. TBC1D15 is required for the accumulation of RhoA. PMID: 24337944
  4. Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology. PMID: 23077178
  5. although only TBC1D15/Rab7-GAP altered Rab7-GTP levels, both Rab7-GAP and mVps39 regulate lysosomal morphology and play a role in maintaining growth factor dependence PMID: 20363736
  6. This paper primarily describes mouse TBC1D15 but also reports the primary structure of human TBC1D15. PMID: 16055087

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Subcellular Location Cytoplasm
Database Links

HGNC: 25694

OMIM: 612662

KEGG: hsa:64786

STRING: 9606.ENSP00000448182

UniGene: Hs.284630

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