Recombinant Human Targeting protein for Xklp2 (TPX2)

1. A PRISMA-compliant systematic review and meta-analysis found that overexpression of TPX2 is related to poor survival rate in most solid tumors, which indicates that the expression level of TPX2 is a significant prognostic parameter and potential therapeutic target in various solid tumors. PMID: 30412141
2. Study suggests AURKA and TPX2 as potential stratification markers for taxane-based radiochemotherapy. lung adenocarcinoma cohort, high expression levels of AURKA and TPX2 were associated with specifically improved overall survival upon taxane-based radiochemotherapy. PMID: 28869599
3. Data found that TPX2 was highly expressed in human bladder cancer tissues. Its overexpression promoted bladder cancer growth and correlated with tumor grade and stage, lymph node metastasis, and poor prognosis. These results support that TPX2 acts as a tumor promoter in human bladder tumor development. PMID: 28799673
4. TPX2 promotes the proliferation and migration of human OC cells by regulating PLK1 expression. PMID: 29865033
5. Together, these results suggest a molecular mechanism of how the Ran-GTP gradient can regulate TPX2-dependent microtubule formation. PMID: 29120325
6. TPX2 was correlated with cell radioresistance PMID: 28636807
7. We show TPX2, a regulator of Aurora-A, is associated with high grade and stage of ccRCC, and is an independent predictor of recurrence. PMID: 28108243
8. detection of TPX2 overexpression could serve as a prognostic marker and therapeutic target for gastric cancer PMID: 27314162
9. High TPX2 expression is associated with gastric cancer. PMID: 28069036
10. This study concludes that the helical region of TPX2 folds upon binding Aurora-A, and that stabilization of this helix does not compromise Aurora-A activation. PMID: 27775325
11. MiR-491 inhibits hepatocellular carcinoma cell proliferation, invasion and migration by downregulating the expression of TPX2. PMID: 27053618
12. expression of both TPX2 and PD-L1 are associated with persistence/recurrence of cervical intraepithelial neoplasia after cervical conization PMID: 26624896
13. the levels and distribution of TPX2 are likely to be determinants of when and where kinesin-5 acts in neurons. PMID: 26257190
14. TPX2 was a target gene of miR-491. PMID: 26279431
15. Propose TPX2 and AURKA as novel co-regulators on the MYC pathway in colorectal neoplasms. PMID: 25632068
16. Aurora A-dependent TPX2 phosphorylation controls mitotic spindle length through regulating microtubule flux. PMID: 26240182
17. These results indicated that TPX2 has an impact on tumor angiogenesis in pancreatic cancer. PMID: 25914189
18. Data show that cytoskeleton associated protein 5 (chTOG) only weakly promotes importin-regulated microtubule nucleation, but acts synergistically with TPX2 protein. PMID: 26414402
19. RAN nucleo-cytoplasmic transport and mitotic spindle assembly partners XPO7 and TPX2 have roles in serous epithelial ovarian cancer PMID: 24625450
20. a causative link between altered function of AURKA-HMMR-TPX2-TUBG1 and breast carcinogenesis in BRCA1/2 mutation carriers PMID: 25830658
21. Identify RHAMM as a critical regulator of TPX2 location/ Aurora kinase A signaling and suggest that RHAMM ensures bipolar spindle assembly and mitotic progression through the integration of biochemical and structural pathways. PMID: 24875404
22. the molecular mechanisms of two distinct activation strategies (autophosphorylation and TPX2-mediated activation) in human Aurora A kinase, was elucidated. PMID: 24867643
23. Dimeric, but not monomeric, Eg5 was differentially inhibited by full-length and truncated TPX2, demonstrating that dimerization or residues in the neck region are important for the interaction of TPX2 with Eg5. PMID: 26018074
24. our study is the first indication of a constitutive control of TPX2 on H4K16ac levels, with potential implications for DNA damage response. PMID: 25365214
25. TPX2 siRNA transfection significantly reduced tumor growth. PMID: 25239289
26. In vitro studies found that TPX2 knockdown significantly inhibited cell proliferation and viability in both Hep3B and HepG2 cells. PMID: 25302620
27. TPX2 expression is associated with cell proliferation and poor prognosis among patients with resected esophageal squamous cell carcinoma PMID: 23963785
28. TPX2 overexpression is associated with medullary thyroid carcinoma. PMID: 24488334
29. The results demonstrated that TPX2 is important in the regulation of tumor growth in cervical cancer and therefore may be a potential therapeutic target as a novel treatment strategy. PMID: 24718984
30. TPX2 plays an important role in promoting tumorigenesis and metastasis of human colon cancer, and may represent a novel prognostic biomarker and therapeutic target for the disease PMID: 24341487
31. This review provides an historic overview of the discovery of TPX2 and summarizes its cytoskeletal and signaling roles with relevance to cancer therapies. [review] PMID: 24556998
32. The expression of TPX2 protein and mRNA were correlated with invasive depth and lymphatic metastasis of esophageal squamous cell carcinoma. PMID: 23725757
33. Data indicate that TPX2 (target protein for Xklp2) may play a role in the development and progression of bladder carcinoma, and suggest that inhibition of TPX2 level may be a novel strategy for therapy of the patients with bladder carcinoma. PMID: 23873098
34. The data support the role of TPX2 as a novel co-activator of Aurora kinase B. PMID: 22560880
35. Data show that five genes CKAP5, KPNB1, RAN, TPX2 and KIF11 were shown to be essential for tumor cell survival in both head and neck squamous cell carcinoma (HNSCC)and non-small cell lung cancer (NSCLC), but most particularly in HNSCC. PMID: 23444224
36. Data indicate that the sensitivity of cell-lines with amplification of AURKA depends upon the activity of the kinase, which correlates with the expression of the regulatory gene products TPX2 and HMMR/RHAMM. PMID: 23328114
37. the regulation of gamma-H2AX signals by TPX2 is not associated with apoptosis or the mitotic functions of TPX2. PMID: 23045526
38. AIM1, ERGIC1, and TPX2 were shown to be highly expressed especially in prostate cancer tissues, and high mRNA expression of ERGIC1 and TMED3 associated with AR and ERG oncogene expression PMID: 22761906
39. TPX2 promote 20q amplicon-driven progression of colorectal adenoma to carcinoma. PMID: 22207630
40. TPX2 shows potential to be used as a new marker for cervical cancer diagnosis and therapy. PMID: 22307108
41. two switches determining Aurora A activation PMID: 21347367
42. TPX2 protects Aurora-A from degradation both in interphase and in mitosis. PMID: 21147853
43. Results demonstrate a role for PP6 as the T-loop phosphatase regulating Aurora A activity bound to its activator TPX2 during mitotic spindle formation. PMID: 21187329
44. association of Aurora-A and TPX2 gives rise to a novel functional unit with oncogenic properties.[review] PMID: 20708655
45. Decreased AurA-TPX2 complex formation in response to irradiation results from reduced cellular levels of TPX2, as a result of protein degradation and decreased translation of TPX2 mRNA. PMID: 21099343
46. TPX2 expression is associated with the progression of malignant astrocytoma. PMID: 20599806
47. Data show that Aurora A(S155R) mutant reduced cellular activity and mislocalization are due to loss of interaction with TPX2. PMID: 19801554
48. TPX2 is required for targeting Aurora-A kinase to the spindle apparatus and Aurora-A might regulate the function of TPX2 during spindle assembly PMID: 12177045
49. spindle formation requires the function of TPX2 to generate a stable bipolar spindle with overlapping antiparallel microtubule arrays PMID: 12389033
50. observations reveal a structural role for hTPX2 in spindles and provide evidence for a balance between microtubule-based motor forces and structural spindle components PMID: 12477396

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HGNC: 1249

OMIM: 605917

KEGG: hsa:22974

STRING: 9606.ENSP00000300403

UniGene: Hs.244580