Code | CSB-EP024405HU |
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Size | $224 |
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Amino acids 19-174 form the expressed segment for recombinant Human TREM2. This TREM2 protein is expected to have a theoretical molecular weight of 21.4 kDa. Expression of this TREM2 protein is conducted in e.coli. The TREM2 coding gene included the N-terminal 6xHis tag, which simplifies the detection and purification processes of the recombinant TREM2 protein in following stages of expression and purification.
Triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is primarily expressed on the cell surface of macrophages, dendritic cells, and microglia in the central nervous system. TREM2 functions as a receptor involved in innate immunity and is implicated in various processes, including phagocytosis, cell adhesion, and inflammatory responses. Its ligands include lipoproteins, apolipoproteins, and other molecules associated with cellular damage. TREM2 has gained attention for its role in neurodegenerative diseases, particularly Alzheimer's disease. It is involved in the regulation of microglial activity and the clearance of apoptotic neurons and cellular debris. Mutations in the TREM2 gene have been linked to an increased risk of Alzheimer's disease and other neurodegenerative disorders, highlighting its importance in maintaining immune homeostasis in the brain. Understanding TREM2 function is crucial for developing therapeutic strategies targeting neuroinflammation and neurodegeneration.There are currently no reviews for this product.