Recombinant Human Unique cartilage matrix-associated protein (UCMA)

Code CSB-YP855482HU
MSDS
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Source Yeast
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Code CSB-EP855482HU
MSDS
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Source E.coli
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Code CSB-EP855482HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP855482HU
MSDS
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Source Baculovirus
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Code CSB-MP855482HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
UCMA
Uniprot No.
Alternative Names
UCMA; C10orf49; Unique cartilage matrix-associated protein [Cleaved into: Unique cartilage matrix-associated protein C-terminal fragment; Ucma-C; Gla-rich protein; GRP)]
Species
Homo sapiens (Human)
Expression Region
27-138
Target Protein Sequence
VSVG TMQMAGEEAS EDAKQKIFMQ ESDASNFLKR RGKRSPKSRD EVNVENRQKL RVDELRREYY EEQRNEFENF VEEQNDEQEE RSREAVEQWR QWHYDGLHPS YLYNRHHT
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
Gene References into Functions
  1. GRP might act as a novel molecular mediator linking inflammation and calcification events PMID: 28542410
  2. The study demonstrates the involvement of GRP in the two major molecular processes affecting osteoarthritis: mineralization and inflammation of articular tissue. PMID: 26337479
  3. Data suggest that novel splice variants of GRP are expressed in cartilage and other tissues (i.e. GRP-F5, GRP-F6); GRP-F1 is predominant splice variant expressed in adult tissues particularly in cartilage of patients with osteoarthritis. PMID: 24867294
  4. full exon resequencing of DNA samples from 17 chronic kidney disease patients (stage 5) and 121 healthy controls in a Swsedish population; the 138Thr > Ser polymorphism seems to be the only non-synonymous SNP found in the UCMA gene in a Swedish population PMID: 24409676
  5. Gla-rich protein (GRP) is a new vitamin K-dependent protein that can bind calcium through Gla residues. PMID: 18836183
  6. The present data strongly suggest an important function of Ucma in the early phase of chondrocyte differentiation. PMID: 17707622
  7. Ucma may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells PMID: 18156182

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Subcellular Location
Secreted, extracellular space, extracellular matrix.
Protein Families
UCMA family
Tissue Specificity
Predominantly expressed in resting chondrocytes.
Database Links

HGNC: 25205

KEGG: hsa:221044

STRING: 9606.ENSP00000367952

UniGene: Hs.112998

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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