Recombinant Human Zinc finger protein 346 (ZNF346)

Code CSB-YP026691HU
MSDS
Size Pls inquire
Source Yeast
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Code CSB-EP026691HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP026691HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP026691HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
ZNF346
Uniprot No.
Alternative Names
DKFZp547M223; Double stranded RNA binding zinc finger protein; Double stranded RNA binding zinc finger protein JAZ; JAZ; Just another zinc finger protein; Zfp346; Zinc finger protein 346; ZN346_HUMAN; Znf346
Species
Homo sapiens (Human)
Expression Region
1-294
Target Protein Sequence
MEYPAPATVQ AADGGAAGPY SSSELLEGQE PDGVRFDRER ARRLWEAVSG AQPVGREEVE HMIQKNQCLF TNTQCKVCCA LLISESQKLA HYQSKKHANK VKRYLAIHGM ETLKGETKKL DSDQKSSRSK DKNQCCPICN MTFSSPVVAQ SHYLGKTHAK NLKLKQQSTK VEALHQNREM IDPDKFCSLC HATFNDPVMA QQHYVGKKHR KQETKLKLMA RYGRLADPAV TDFPAGKGYP CKTCKIVLNS IEQYQAHVSG FKHKNQSPKT VASSLGQIPM QRQPIQKDST TLED
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity. May bind to specific miRNA hairpins.
Gene References into Functions
  1. JAZ directly binds E2F1 in vitro in a dsRNA-independent manner, and JAZ's dsRNA binding ZF domains, which are necessary for localizing JAZ to the nucleus, are required for repression of transcriptional activity in vivo. PMID: 21715977
  2. JAZ is exported by exportin-5 but translocates back into nuclei by a facilitated diffusion mechanism PMID: 15254228
Subcellular Location
Nucleus, nucleolus. Cytoplasm. Note=Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5.
Database Links

HGNC: 16403

OMIM: 605308

KEGG: hsa:23567

STRING: 9606.ENSP00000350869

UniGene: Hs.484259

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