Recombinant Human Zinc finger protein GLI1 (GLI1), partial

1. Study showed the expression levels of Gli1 and HER2 were significantly higher in gastric cancer, and they are positively related. Gli1 positive patients live a shorter survival time independently of HER2 status. In addition, suppressing the expression level of Gli1 can decrease the cell viability and migration ability in cells and subcutaneous tumors. PMID: 29321573
2. The results provide new evidence of Numb and Gli1 on the clinical characteristics of Malignant pleural mesothelioma, which may be helpful in clinical diagnosis and targeted therapy. Further research with larger sample size is needed PMID: 30197333
3. Frameshift Mutation of GLI1 is associated with Colorectal Cancer. PMID: 28664474
4. Histone deacetylase 6 (HDAC6) inhibition enhanced glioma stem cells (GSCs) radiosensitivity via inactivating sonic hedgehog protein (SHH)/glioma-associated oncogene homolog 1 (Gli1) pathway. PMID: 29222038
5. HPI-1 worked more effectively than GANT-58 against breast carcinoma cells. In conclusion, HPI-1 could inhibit cell proliferation, reduce cell invasion and decrease cancer stem cell population in breast cancer cells. To target Gli-1 could be a potential strategy to suppress breast cancer stem cells. PMID: 29734730
6. High GLI1 expression is associated with unfavorable OS and FPS in patients with gastric cancer. As a member of the Hedgehog signaling pathway, GLI1 co-expressed genes are also largely enriched in PI3K/AKT pathway in gastric cancer. PMID: 29596399
7. the results suggest that aberrant expression of Gli1 serves a role in HSCR by targeting EDNRB. PMID: 29484400
8. Abnormal elevation of Gli1 and decrease of miR-361 were found in esophageal cancer tissues. MiR-361 weakened invasion of cancer cells and impeded EMT process via the inhibition of Gli1. PMID: 29125483
9. Data show that miR-150 inhibits glioma-associated oncogene homolog 1 (Gli1) expression via targeting 3'-UTR of Gli1 gene. PMID: 29081413
10. Downregulation of miR-150 and elevation of Gli1 promote the development and invasion of colorectal cancer cell Epithelial-mesenchymal transition (EMT). MiR-150 attenuated the progression of colorectal cancer cell EMT via inhibiting Gli1. PMID: 29164577
11. data collectively suggest that silencing of PRMT1 exerts anti-catabolic and anti-inflammatory effects on IL-1beta-induced chondrocytes via suppressing the Gli-1 mediated Hedgehog signaling pathway, indicating that PRMT1 plays a critical role in OA development and serves as a promising therapeutic target for OA. PMID: 28744817
12. Shh and Gli1 expression were associated with lymph node metastasis, TNM stage and tumor recurrence, suggesting Shh and Gli1 protein could become the valuable biomarker in evaluating the lymph node metastasis in oral squamous cell carcinoma. PMID: 28886265
13. we have identified an oncogenic MALAT1-GLI1 fusion gene in all cases of gastroblastoma that may serve as a diagnostic biomarker. PMID: 28731043
14. Analysis of fibroblasts from a patient with homozygous C-terminal truncation of GLI1 demonstrated that the corresponding mutant GLI1 protein is fabricated by patient cells and becomes upregulated in response to Hh signaling. PMID: 28973407
15. The results showed that Shh and Gli1 were upregulated in prostate cancer tissues and were targeted by a phytogenic neoplastic compound carnosol. PMID: 28886322
16. Our finding demonstrated that triple phosphorylation of GLI1 by AMPK on Ser-102, Ser-408 and Thr-1074 increases the cytoplasmic localization and binding stability to E3 ligase beta-TrCP, ultimately driving GLI1 protein degradation. PMID: 28562331
17. Our results identify a new molecular mechanism involving miR-326 and Arrb1 as regulators of Sonic hedgehog medulloblastoma Cancer stem cells . Specifically, low levels of Arrb1 and miR-326 trigger and maintain Hh/Gli signaling and self-renewal PMID: 28716052
18. study reveals that the USP48-Gli1 regulatory axis is critical for glioma cell proliferation and glioblastoma tumorigenesis. PMID: 28623188
19. Gli-1 is a credible indicator for highly aggressive tumor with poor prognosis in gastric cancer patients [meta-analysis] PMID: 27634907
20. Gli may be critical for lung adenocarcinoma metastasis. A novel Gli inhibitor shows promise as a therapeutic agent by preventing cell migration and invasion in vitro and significantly reducing tumor growth and increasing E-Cadherin expression in vivo. PMID: 27533453
21. Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression. PMID: 27793025
22. Data demonstrate involvement of transcription and of DNA replication licensing factors by non-transcriptional and transcriptional mechanisms in the GLI-dependent mechanism of action of GANT61 in Ht29 cells. PMID: 27863397
23. Oxytocin receptor signaling promoted the angiogenic behaviors of HUVECs via Gli1-indcued transcription of HIF-1alpha. PMID: 28445928
24. Galectin-1 promotes invasion and epithelial mesenchymal transformation in gastric cancer cells via activation of the non-canonical Hh pathway in Gli-1 dependent manner. PMID: 27835885
25. The mechanism by which GLI1 loss of function sensitized tumor cells to vorinostat-induced apoptosis is at least in part through interactions with vorinostat to alter gene expression in a manner that favored apoptosis. PMID: 26868908
26. these findings propose that A3AR agonist induces cell cycle arrest and apoptosis in breast cancer stem cells by inhibition of ERK1/2 and GLI-1 cascade. PMID: 28230290
27. Gli1 could be a stem cell marker and an indicator of poor prognosis in patients with ductal breast carcinoma. PMID: 28965964
28. Expression of SHH and GLI1 may be useful prognostic markers of Merkel cell carcinoma because increased expression was associated with better prognosis. Report high rate of silent mutations in GLI1 exon 5. PMID: 28551328
29. Results found that GLI1 expression is regulated by GAL1 in gastric cancer tissue specimen and cell lines. PMID: 27836001
30. Results indicated that GLI1 activation in TN-IBC as in TNBC, plays a vital role in promoting cell proliferation, motility, tumor growth, and formation of tumor emboli. PMID: 28965853
31. High gli1 expression is associated with Small Cell Lung Cancer. PMID: 28870922
32. This inhibitory effect on cell growth was partially rescued by exogenous KRT17 expression. In the KRT17-positive regions in OSCCs, GLI-1 or GLI-2 was frequently detected, and the number of cells with cleaved caspase-3 positive was decreased. CONCLUSIONS: KRT17 promotes tumor cell growth, at least partially, through its anti-apoptotic effect as a result of the KRT17 overexpression by GLIs in OSCC PMID: 28342001
33. Results indicate that GLI1 is important for maintaining the invasive and mesenchymal-like properties of melanoma cells independent of MITF. PMID: 28635133
34. The data described herein provide the first identification of a DYRK1A-mediated site of phosphorylation on GLI1 within its NLS and may serve as a valuable mechanism for further understanding Hh signaling modulation. PMID: 28735864
35. Case Report: gastric pericytoma harboring the exceptionally rare translocation t(7;12) resulting in ACTB-GLI1 gene fusion. PMID: 26980027
36. USP21 recruits and stabilises Gli1 at the centrosome. PMID: 27621083
37. Gli1 expression was significantly correlated with T stage lymph node metastasis, and clinical stage of lung squamous cell carcinoma. PMID: 28286162
38. Gli1 role in cell proliferation and differentiation PMID: 28458545
39. Gli1 inhibitor GANT61 and SHH siRNA synergistically enhanced cytotoxicity induced by itraconazole in MCF-7 cells. PMID: 27810405
40. Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors. PMID: 27694322
41. Our studies demonstrate an important role for smoothened and glioma-associated oncogene homology-1 in gastric cancer and suggest inhibition of hedgehog pathway as a novel and potent strategy to treat gastric cancer patients PMID: 28675107
42. GANT61, which is a targeted inhibitor of Gli1 and Gli2, decreased cell viability and promoted cell apoptosis. Thus, TGF-b1 induced EMT in neuroblastoma cells to increase their migration. Specifically, EMT induced by TGF-b1 in neuroblastoma cells did not depend on the Smad signaling pathway, and the transcription factor Gli participated in TGF-b1-induced EMT independent of Smad signaling. PMID: 28393230
43. Gli1 expression was detected in most ERM specimens. Patients who had DR or OCT findings indicating chronic retinal insults showed higher Gli1 expression. Gli1 may have a role in the pathogenesis of ERM after chronic retinal insults. PMID: 28134963
44. Overexpression of GLI1 through a recurrent MALAT1-GLI1 translocation or GLI1 up-regulation delineates a pathogenically distinct subgroup of plexiform fibromyxomas with activation of the Sonic Hedgehog signalling pathway. PMID: 27101025
45. Gli1 and Gli2 exhibited different functions in the regulation of p63 expression or proliferation of p63(+) cells in Kras-AR driven tumors. PMID: 27760825
46. The results from this study demonstrate the potential importance of the two-stem-loop motif as a target region for the inhibition of the CRD-BP-GLI1 RNA interaction and Hedgehog signaling pathway. PMID: 27036131
47. High expression of gli1 is associated with glioma chemoresistance. PMID: 27662839
48. High Gli-1 expression is associated with pancreatic cancer. PMID: 26815504
49. Our study is the first to demonstrate the associations of high nuclear Gli1 expression with resistance to trastuzumab-based NAT and subsequent worse prognosis in HER2-positive disease. These findings suggest that the nuclear Gli1 protein may be a novel target of NAT for HER2-positive breast cancer. PMID: 26526577
50. GLI is an oncogenic transcription factor in the SHH pathway, and targeting GLI with GANT61 results in favourable antitumour activity and targeted therapy. PMID: 27601167

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HGNC: 4317

OMIM: 165220

KEGG: hsa:2735

STRING: 9606.ENSP00000228682

UniGene: Hs.632702