Recombinant Human Zinc finger protein with KRAB and SCAN domains 4 (ZKSCAN4)

Code CSB-YP836168HU
MSDS
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Source Yeast
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Code CSB-EP836168HU
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Source E.coli
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Code CSB-EP836168HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP836168HU
MSDS
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Source Baculovirus
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Code CSB-MP836168HU
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
ZKSCAN4
Uniprot No.
Alternative Names
FLJ32136; P1P373C6; p373c6.1 (novel C2H2 type zinc finger protein); P373c6.1; Zinc finger protein 307; Zinc finger protein 427; Zinc finger protein with KRAB and SCAN domains 4; Zinc finger with KRAB and SCAN domains 4; ZKSC4_HUMAN; ZKSCAN4; ZNF427
Species
Homo sapiens (Human)
Expression Region
1-545
Target Protein Sequence
MAREPRKNAA LDAQSAEDQT GLLTVKVEKE EASALTAEVR APCSPARGPE RSRQRFRGFR YPEAAGPREA LSRLRELCGQ WLQPEMHSKE QILELLVLEQ FLTILPGNLQ SWVREQHPES GEEVVVLLEY LERQLDEPAP QVPVGDQGQE LLCCKMALLT QTQGSQSSQC QPMKALFKHE SLGSQPLHDR VLQVPGLAQG GCCREDAMVA SRLTPGSQGL LKMEDVALTL TPGWTQLDSS QVNLYRDEKQ ENHSSLVSLG GEIQTKSRDL PPVKKLPEKE HGKICHLRED IAQIPTHAEA GEQEGRLQRK QKNAIGSRRH YCHECGKSFA QSSGLTKHRR IHTGEKPYEC EDCGKTFIGS SALVIHQRVH TGEKPYECEE CGKVFSHSSN LIKHQRTHTG EKPYECDDCG KTFSQSCSLL EHHKIHTGEK PYQCNMCGKA FRRNSHLLRH QRIHGDKNVQ NPEHGESWES QGRTESQWEN TEAPVSYKCN ECERSFTRNR SLIEHQKIHT GEKPYQCDTC GKGFTRTSYL VQHQRSHVGK KTLSQ
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
May be involved in the transcriptional activation of MDM2 and EP300 genes.
Gene References into Functions
  1. our results indicate that ZNF307 may serve as a tumor suppressor and inhibits cell proliferation of hepatocellular carcinoma via inducing apoptosis PMID: 28765950
  2. ZNF307 ameliorates pressure overload-induced cardiac hypertrophy by inhibiting the activity of NF-kappaB-signaling pathway PMID: 28223477
  3. ZNF307 might suppress p53-p21 pathway through activating MDM2 and EP300 expression and inducing p53 degradation PMID: 17910948
  4. The SCAN- and KRAB-domain-containing zinc finger protein 307 (ZKSCAN4) was co-precipitated with the receptor when both proteins were overexpressed in HEK293 cells. PMID: 19008334
Subcellular Location
Nucleus.
Protein Families
Krueppel C2H2-type zinc-finger protein family
Tissue Specificity
Expressed in adult heart, brain, placenta, lung and kidney, but not in adult liver and skeletal muscle. In 17-day old embryo, detected in liver, skeletal muscle, brain, heart and small intestine.
Database Links

HGNC: 13854

OMIM: 611643

KEGG: hsa:387032

STRING: 9606.ENSP00000366509

UniGene: Hs.44720

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