Recombinant Macaca fascicularis Tumor necrosis factor ligand superfamily member 6(FASLG),partial

Product Type Recombinant Protein
Uniprot No. P63308
Species Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Gene Names FASLG
Protein Names Recommended name: Tumor necrosis factor ligand superfamily member 6 Alternative name(s): CD95 ligand Short name= CD95-L Fas antigen ligand Short name= Fas ligand Short name= FasL CD_antigen= CD178 Cleaved into the f
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Function Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis.
Subcellular Location Cell membrane, Single-pass type II membrane protein, Cytoplasmic vesicle lumen, Lysosome lumen, Note=Colocalizes with the SPPL2A protease at the cell membrane, Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination, SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted, Note=May be released into the extracellular fluid by cleavage from the cell surface, SUBCELLULAR LOCATION: FasL intracellular domain: Nucleus
Protein Families Tumor necrosis factor family
Database Links

KEGG: mcf:102139406

UniGene: Mfa.6266

Pathway MAPK signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Necroptosis
Ras signaling pathway
Natural killer cell mediated cytotoxicity
FoxO signaling pathway
Neurotrophin signaling pathway

Product Details for Different Expression Systems

Product Name Recombinant Macaca fascicularis Tumor necrosis factor ligand superfamily member 6(FASLG),partial,Yeast
Code CSB-YP008434MOV1
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Protein Description Partial
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Macaca fascicularis Tumor necrosis factor ligand superfamily member 6(FASLG),partial,Baculovirus
Code CSB-BP008434MOV1
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Protein Description Partial
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Macaca fascicularis Tumor necrosis factor ligand superfamily member 6(FASLG),partial,Mammalian cell
Code CSB-MP008434MOV1
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Protein Description Partial
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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