FASLG encodes the Fas ligand, also commonly known as CD95 ligand. This protein is a type II transmembrane protein belonging to the tumor necrosis factor (TNF) family. It binds to the Fas receptor, triggering a cascade of events. When FasL binds to Fas, it leads to the activation of caspases, which are responsible for initiating apoptosis. This process is essential in immune regulation and maintaining tissue homeostasis.
Dysregulation of the Fas-FasL interaction is linked to various diseases, such as autoimmune lymphoproliferative syndrome (ALPS). In terms of drug development, agents that target the Fas-FasL pathway are being investigated for potential applications in cancer treatment, aiming to induce apoptosis in tumor cells and enhance the immune response against malignancies.
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
FASLG Antibody (CSB-PA008434LA01HU)
Validated Data
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA008434LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA008434LA01HU at dilution of 1:100
Immunofluorescence staining of Hela cells with CSB-PA008434LA01HU at 1:330, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Human Factor-related Apoptosis ligand,FASL ELISA Kit (CSB-E04544h)
Validated Data
Code: CSB-E04544h
Size: 96T,5×96T,10×96T
Sensitivity: 7.81 pg/mL
Detection Range: 31.25 pg/mL-2000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
The following FASLG reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
FASLG Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA008434LA01HU | FASLG Antibody | Human | ELISA, IHC, IF |
CSB-PA008434LB01HU | FASLG Antibody, HRP conjugated | Human | ELISA |
CSB-PA243242 | FASLG Antibody | Human | ELISA,WB,IHC |
CSB-PA002482 | FASLG Antibody | Human,Mouse | WB, IHC, IF, ELISA |
CSB-PA129637 | FASLG Antibody | Human,Mouse,Rat | ELISA,IHC |
FASLG Antibodies for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA008434ZA01MOV | FASLG Antibody | Macaca fascicularis | ELISA, WB (ensure identification of antigen) |
FASLG Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-EP008434HU | Recombinant Human Tumor necrosis factor ligand superfamily member 6 (FASLG), partial | E.coli |
CSB-EP008434HU(A4) | Recombinant Human Tumor necrosis factor ligand superfamily member 6 (FASLG), partial | E.coli |
CSB-YP008434HU | Recombinant Human Tumor necrosis factor ligand superfamily member 6 (FASLG), partial | Yeast |
CSB-YP008434HU(A4) | Recombinant Human Tumor necrosis factor ligand superfamily member 6 (FASLG), partial | Yeast |
CSB-BP008434HU CSB-MP008434HU CSB-EP008434HU-B |
Recombinant Human Tumor necrosis factor ligand superfamily member 6 (FASLG) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-BP008434HU(A4) CSB-MP008434HU(A4) CSB-EP008434HU(A4)-B |
Recombinant human Tumor necrosis factor ligand superfamily member 6 | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FASLG Proteins for Macaca mulatta (Rhesus macaque)
Code | Product Name | Source |
---|---|---|
CSB-YP008434MOW CSB-EP008434MOW CSB-BP008434MOW CSB-MP008434MOW CSB-EP008434MOW-B |
Recombinant Macaca mulatta Tumor necrosis factor ligand superfamily member 6 (FASLG), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FASLG Proteins for Felis catus (Cat) (Felis silvestris catus)
Code | Product Name | Source |
---|---|---|
CSB-YP771249CA CSB-EP771249CA CSB-BP771249CA CSB-MP771249CA CSB-EP771249CA-B |
Recombinant Cat Tumor necrosis factor ligand superfamily member 6 (FASLG), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FASLG Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP857726PI CSB-EP857726PI CSB-BP857726PI CSB-MP857726PI CSB-EP857726PI-B |
Recombinant Pig Tumor necrosis factor ligand superfamily member 6 (FASLG), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FASLG Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
Code | Product Name | Source |
---|---|---|
CSB-YP860198DRI CSB-EP860198DRI CSB-BP860198DRI CSB-MP860198DRI CSB-EP860198DRI-B |
Recombinant Cercocebus atys Tumor necrosis factor ligand superfamily member 6 (FASLG), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FASLG Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-CF008434RA | Recombinant Rat Tumor necrosis factor ligand superfamily member 6 (Faslg) | in vitro E.coli expression system |
CSB-YP008434RA1 CSB-EP008434RA1 CSB-BP008434RA1 CSB-MP008434RA1 CSB-EP008434RA1-B |
Recombinant Rat Tumor necrosis factor ligand superfamily member 6 (Faslg), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FASLG Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF008434MO | Recombinant Mouse Tumor necrosis factor ligand superfamily member 6 (Faslg) | in vitro E.coli expression system |
CSB-YP008434MO1 CSB-EP008434MO1 CSB-BP008434MO1 CSB-MP008434MO1 CSB-EP008434MO1-B |
Recombinant Mouse Tumor necrosis factor ligand superfamily member 6 (Faslg), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FASLG Proteins for Macaca nemestrina (Pig-tailed macaque)
Code | Product Name | Source |
---|---|---|
CSB-CF008434MOX | Recombinant Macaca nemestrina Tumor necrosis factor ligand superfamily member 6 (FASLG) | in vitro E.coli expression system |
CSB-YP008434MOX1 CSB-EP008434MOX1 CSB-BP008434MOX1 CSB-MP008434MOX1 CSB-EP008434MOX1-B |
Recombinant Macaca nemestrina Tumor necrosis factor ligand superfamily member 6 (FASLG), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FASLG Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Code | Product Name | Source |
---|---|---|
CSB-CF008434MOV | Recombinant Macaca fascicularis Tumor necrosis factor ligand superfamily member 6 (FASLG) | in vitro E.coli expression system |
CSB-YP008434MOV1 CSB-BP008434MOV1 CSB-MP008434MOV1 CSB-EP008434MOV1-B |
Recombinant Macaca fascicularis Tumor necrosis factor ligand superfamily member 6 (FASLG), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF008434MOV2 | Recombinant Macaca fascicularis Tumor necrosis factor ligand superfamily member 6 (FASLG), partial | in vitro E.coli expression system |
CSB-EP008434MOV1 | Recombinant Macaca fascicularis Tumor necrosis factor ligand superfamily member 6 (FASLG), partial | E.coli |
FASLG ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04544h | Human Factor-related Apoptosis ligand,FASL ELISA Kit | serum, plasma, cell culture supernates | 7.81 pg/mL |
FASLG ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04545m | Mouse Factor-related Apoptosis ligand,FASL ELISA Kit | serum, plasma, tissue homogenates | 1.95 pg/mL |
FASLG ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E07325r | Rat Factor-related Apoptosis ligand,FASL ELISA Kit | serum, plasma, tissue homogenates | 7.8 pg/mL |