Tumor necrosis factor ligand superfamily member 6 is a protein in humans that is encoded by FASLG gene. Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells
The following FASLG reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
FASLG Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA008434LA01HU | FASLG Antibody |
Human | ELISA, IHC, IF |
CSB-PA008434LB01HU | FASLG Antibody, HRP conjugated |
Human | ELISA |
CSB-PA243242 | FASLG Antibody |
Human | ELISA,WB,IHC |
CSB-PA002482 | FASLG Antibody |
Human,Mouse | WB, IHC, IF, ELISA |
CSB-PA129637 | FASLG Antibody |
Human,Mouse,Rat | ELISA,IHC |
FASLG Antibodies for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA008434ZA01MOV | FASLG Antibody |
Macaca fascicularis | ELISA, WB (ensure identification of antigen) |
FASLG Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-EP008434HU | Recombinant Human Tumor necrosis factor ligand superfamily member 6 (FASLG), partial |
E.coli |
CSB-EP008434HU(A4) | Recombinant Human Tumor necrosis factor ligand superfamily member 6 (FASLG), partial |
E.coli |
CSB-YP008434HU | Recombinant Human Tumor necrosis factor ligand superfamily member 6 (FASLG), partial |
Yeast |
CSB-YP008434HU(A4) | Recombinant Human Tumor necrosis factor ligand superfamily member 6 (FASLG), partial |
Yeast |
CSB-BP008434HU CSB-MP008434HU CSB-EP008434HU-B |
Recombinant Human Tumor necrosis factor ligand superfamily member 6 (FASLG) |
Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-BP008434HU(A4) CSB-MP008434HU(A4) CSB-EP008434HU(A4)-B |
Recombinant human Tumor necrosis factor ligand superfamily member 6 |
Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FASLG Proteins for Macaca mulatta (Rhesus macaque)
Code | Product Name | Source |
---|---|---|
CSB-YP008434MOW CSB-EP008434MOW CSB-BP008434MOW CSB-MP008434MOW CSB-EP008434MOW-B |
Recombinant Macaca mulatta Tumor necrosis factor ligand superfamily member 6 (FASLG), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FASLG Proteins for Felis catus (Cat) (Felis silvestris catus)
Code | Product Name | Source |
---|---|---|
CSB-YP771249CA CSB-EP771249CA CSB-BP771249CA CSB-MP771249CA CSB-EP771249CA-B |
Recombinant Cat Tumor necrosis factor ligand superfamily member 6 (FASLG), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FASLG Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP857726PI CSB-EP857726PI CSB-BP857726PI CSB-MP857726PI CSB-EP857726PI-B |
Recombinant Pig Tumor necrosis factor ligand superfamily member 6 (FASLG), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FASLG Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
Code | Product Name | Source |
---|---|---|
CSB-YP860198DRI CSB-EP860198DRI CSB-BP860198DRI CSB-MP860198DRI CSB-EP860198DRI-B |
Recombinant Cercocebus atys Tumor necrosis factor ligand superfamily member 6 (FASLG), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FASLG Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-CF008434RA | Recombinant Rat Tumor necrosis factor ligand superfamily member 6 (Faslg) |
in vitro E.coli expression system |
CSB-YP008434RA1 CSB-EP008434RA1 CSB-BP008434RA1 CSB-MP008434RA1 CSB-EP008434RA1-B |
Recombinant Rat Tumor necrosis factor ligand superfamily member 6 (Faslg), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FASLG Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF008434MO | Recombinant Mouse Tumor necrosis factor ligand superfamily member 6 (Faslg) |
in vitro E.coli expression system |
CSB-YP008434MO1 CSB-EP008434MO1 CSB-BP008434MO1 CSB-MP008434MO1 CSB-EP008434MO1-B |
Recombinant Mouse Tumor necrosis factor ligand superfamily member 6 (Faslg), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FASLG Proteins for Macaca nemestrina (Pig-tailed macaque)
Code | Product Name | Source |
---|---|---|
CSB-CF008434MOX | Recombinant Macaca nemestrina Tumor necrosis factor ligand superfamily member 6 (FASLG) |
in vitro E.coli expression system |
CSB-YP008434MOX1 CSB-EP008434MOX1 CSB-BP008434MOX1 CSB-MP008434MOX1 CSB-EP008434MOX1-B |
Recombinant Macaca nemestrina Tumor necrosis factor ligand superfamily member 6 (FASLG), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FASLG Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Code | Product Name | Source |
---|---|---|
CSB-CF008434MOV | Recombinant Macaca fascicularis Tumor necrosis factor ligand superfamily member 6 (FASLG) |
in vitro E.coli expression system |
CSB-YP008434MOV1 CSB-BP008434MOV1 CSB-MP008434MOV1 CSB-EP008434MOV1-B |
Recombinant Macaca fascicularis Tumor necrosis factor ligand superfamily member 6 (FASLG), partial |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF008434MOV2 | Recombinant Macaca fascicularis Tumor necrosis factor ligand superfamily member 6 (FASLG), partial |
in vitro E.coli expression system |
CSB-EP008434MOV1 | Recombinant Macaca fascicularis Tumor necrosis factor ligand superfamily member 6 (FASLG), partial |
E.coli |
FASLG ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04544h | Human Factor-related Apoptosis ligand,FASL ELISA Kit |
serum, plasma, cell culture supernates | 7.81 pg/mL |
FASLG ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04545m | Mouse Factor-related Apoptosis ligand,FASL ELISA Kit |
serum, plasma, tissue homogenates | 1.95 pg/mL |
FASLG ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E07325r | Rat Factor-related Apoptosis ligand,FASL ELISA Kit |
serum, plasma, tissue homogenates | 7.8 pg/mL |
FASLG gene encodes FAS ligand, a homotrimeric type II transmembrane protein belonging to the tumor necrosis factor (TNF) family [1]. FASLG is also called FASL, CD95L, or TNFSF6 (Tumor necrosis factor ligand superfamily member 6). FASL is mainly expressed in activated T lymphocytes and Natural Killer (NK) cells [2][3] and also has constitutive expression in immune-privileged sites such as the eyes and testis [4][5]. Bossi G and Griffiths GM found that FasL is stored in specialized secretory lysosomes in T cells and NK cells after synthesis, and the delivery of FasL to the cell surface may be associated with activation of these cells [6]. It has been reported that the cytoplasmic tail of FasL transduces the proliferation signal in CD8-T cells [7] and propagates a signal to arrest the cell cycle in CD4-T cells [8]. In the Fas-mediated apoptotic pathway, binding of FasL drives Fas clustering and binding of Fas to FADD. FADD recruits caspase-8 and caspase-10 to form the death-inducing signaling complex (DISC), triggering the cleavage of several pro-caspases and eventually inducing apoptosis [9]. In addition to its role in apoptosis, FASL is involved in immune privilege [5] and a cytotoxic T lymphocyte (CTL)-induced tissue destruction [10]. Significantly increased levels of FASL is detected in numerous diseases such as hemophagocytic syndrome [11], Diamond-Blackfan anemia [11], rheumatoid arthritis [13], myocarditis [12], and acute GvHD (graft-versus-host disease) [14].
[1] Suda T, Takahashi T, et al. Molecular cloning and expression of the Fas ligand: a novel member of the tumor necrosis factor family [J]. Cell 1993, 75: 1169– 78.
[2] Oshimi Y, Oda S, et al. Involvement of Fas ligand- and Fas-mediated pathway in the cytotoxicity of human natural killer cells [J]. J. Immunol. 1996, 157: 2909– 15.
[3] Suda T, Okazaki T, et al. Expression of the Fas ligand in T-cell-lineage [J]. J. Immunol. 1995, 154: 3806– 1.
[4] Griffith TS, Brunner T, et al. Fas ligand-induced apoptosis as a mechanism of immune privilege [J]. Science 1995, 270: 1189– 92.
[5] Green DR, Ferguson TA. The role of Fas ligand in immune privilege [J]. Nat Rev Mol Cell Biol 2001, 2:917–24.
[6] Bossi G, Griffiths GM. Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells [J]. Nat. Med. 1999, 5: 90– 96.
[7] Suzuki I, Fink PJ. Maximal proliferation of cytotoxic T lymphocytes requires reverse signaling through Fas ligand [J]. J. Exp. Med. 1998, 187:123–28.
[8] Alnemri ES, Livingston DJ, et al. Human ICE/CED-3 protease nomenclature [J]. Cell 1996, 87:171.
[9] Nagata S. Fas ligand-induced apoptosis [J]. Annu Rev Genet 1999, 33:29–55.
[10] Nagata S, Golstein P. The Fas death factor [J]. Science 1995, 267: 1449– 56.
[11] Hasegawa D, Kojima S, et al. Elevation of the serum Fas ligand in patients with hemophagocytic syndrome and Diamond-Blackfan anemia [J]. Blood 1998, 91: 2793– 99.
[12] Toyozaki T, Hiroe M, et al. Levels of soluble Fas ligand in myocarditis [J]. Am. J. Cardiol. 1998, 82: 246– 48.
[13] Nozawa K, Kayagaki N, et al. Soluble Fas (APO-1, CD95) and soluble Fas ligand in rheumatic diseases [J]. Arthritis Rheum. 1997, 40: 1126– 29.
[14] Kanda Y, Tanaka Y, et al. Increased soluble Fas-ligand in sera of bone marrow transplant recipients with acute graft-versus-host disease [J]. Bone Marrow Transplant. 1998, 22: 751– 54.