Recombinant Mouse A disintegrin and metalloproteinase with thrombospondin motifs 1 (Adamts1)

1. The developmental arrest of early secondary follicles following furin disruption might be rooted in the loss of the mature form of ADAMTS1 and compromised proliferation of granulosa cells in mutant mice. PMID: 28569793
2. Data show that NOTCH1 is a target of ADAMTS1 metalloproteinase activity, which reduces Notch signaling, leading to increased satellite cell activation. PMID: 28939843
3. Reduced tumors in ADAMTS1 knockout mice displayed a paradoxical increase in vascular density and vascular-related genes; a detailed characterization revealed an impaired vasculature, along with a minor infiltration of macrophages. melanoma xenografts showed a relevant induction of its expression in stroma compartments. PMID: 27120788
4. Adamts1 acts as an extracellular matrix 'modifier', with miR-181d-induced downregulation, that regulates adipocyte lineage commitment and obesity. PMID: 27447109
5. Genetic haploinsufficiency of Adamts1 in mice causes thoracic aortic aneurysms and dissections similar to Marfan syndrome. PMID: 28067899
6. An ADAMTS1 blocking antibody suppressed the SPARC-induced collagen I secretion, indicating that SPARC promoted collagen production directly through ADAMTS1 interaction. In conclusion, ADAMTS1 is an important mediator of SPARC-regulated cardiac aging. PMID: 27143554
7. increased expression of ADAMTS1 protein in macrophages and neutrophils that infiltrated aortic tissues may promote the progression of acute aortic dissection PMID: 26563155
8. The resilience of casp1(-/-) mice to SIRS lethality is associated with a lower inflammatory response, loss of hippocampal gene coexpression patterns, and increased hippocampal Adamts1 gene expression. PMID: 25633245
9. Adamts-1 upregulation by inducers of pathological vascular remodeling is mediated by specific signal transduction pathways involving NFAT or C/EBPbeta transcription factors. PMID: 26217013
10. Western blot analyses indicated that aggrecanase-generated proteoglycan fragments are produced after SCI. PMID: 23562508
11. Adamts1 potentially contributes to the increased serum levels of CTX in rickets/osteomalacia. PMID: 23261447
12. The present study suggests a functional coupling between the GABAergic system and the transcriptional regulation of the two genes (Btg2 and Adamsts1) in the hippocampus of adult mice. PMID: 22913326
13. ADAMTS1 is associated with regulating neural plasticity. PMID: 23071766
14. These results reveal that Adamts1 has an impact on bone mineral density and thus further confirm Adamts1 as a potent regulator of bone remodeling. PMID: 22002813
15. fibulin-1 regulates versican-dependent events in ventricular morphogenesis by promoting ADAMTS1 cleavage of versican leading to suppression of trabecular cardiomyocyte proliferation mediated by the ErbB2-Map kinase pathway. PMID: 22183742
16. Pericyte-derived TIMP3 stabilized and ADAMTS1 destabilized the capillary tubular networks PMID: 22383695
17. results indicate that up-regulation of ADAMTS1 in hepatic stellate cells constitutes a new mechanism for control of TGF-beta activation in chronic liver disease. PMID: 21826695
18. Data demonstrate that Adamts1 and Adamts4 play redundant and essential roles in perinatal kidney development. PMID: 21584905
19. ADAMTS-1 is implicated as having a proangiogenic role. PMID: 21411713
20. AHR, a novel acute hypoxia-response sequence, drives reporter gene expression under hypoxia in vitro and in vivo. PMID: 20795945
21. ADAMTS1 is involved in the remodeling of the extracellular matrix to facilitate assembly or the viscoelastic COC matrix before ovulation. PMID: 20592310
22. Results demonstrate the shear stress-dependent expression of ADAMTS1 in vitro and in vivo and suggest it as a mechanism connecting blood flow with the regulation of angiogenesis. PMID: 20665671
23. A mouse model of renal insufficiency with arteriovenous fistula was developed that had increased expression of ADAMTS-1 at the outflow vein with venous stenosis. PMID: 20598569
24. Increased cleavage of versican in the interzone accompanies cavitation and suggests that proteolytic modification by Adamts1 may be important during the process of synovial joint maturation. PMID: 20101710
25. results indicate that the antiangiogenic activity of TSP1 is differentially regulated by ADAMTS1 in the liver and lung, emphasizing the concept that regulation of angiogenesis is varied in different tissue environments. PMID: 20103648
26. extracellular matrix degrading enzyme PMID: 11831030
27. observations suggest that one function of ADAMTS-1 in ovulation is to cleave versican in the expanded COC matrix and that the anovulatory phenotype of progesterone receptor KO mice is at least partially due to loss of this function PMID: 12907688
28. A functional Adamts-1 is required for normal ovulation to occur, and hence the Adamts-1 gene plays an important role in female fertility, primarily during the tissue remodeling process of ovulation. PMID: 14668204
29. overexpression of only the C-terminal half region of ADAMTS-1 suppressed tumor growth in mice; significant reduction in tumor metastatic potential was observed in ADAMTS-1-transfected CHO cells in an experimental metastasis assay PMID: 15194513
30. Lutropin and progesterone receptors exert distinct but coordinate effects on transactivation of the ADAMTS-1 gene in granulosa cells in vivo and in vitro PMID: 15256533
31. Adamts-1 is required for the normal development of the kidney. PMID: 15615810
32. ADAMTS1, ADAMTS4, and ADAMTS5 are expressed in patterns that relate to the expression pattern of versican in granulosa cells of small follicles, expanded cumulus cell-oocyte complexes, and endothelial cells of the ovary. PMID: 15659705
33. suggest a role of ADAMTS1 in keratinocyte differentiation and migration of fibroblasts and endothelial cells in healing skin wounds PMID: 15843381
34. observations suggest that a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 plays an important role in mouse uterine tissue remodelling during the oestrous cycle PMID: 15907280
35. fibulin-1 is a new regulator of ADAMTS-1-mediated proteoglycan proteolysis and may play an important role in proteoglycan turnover in tissues where there is overlapping expression PMID: 16061471
36. These results suggest that ADAMTS-1 is important for follicular development, for maintaining normal granulosa cell layers, and for the organization of the medullary vascular network. PMID: 16216914
37. Plays a critical role in tissue matrix remodeling that sustains ovarian follicle growth. PMID: 17097630
38. Trabeculation requires Brg1, a chromatin remodeling protein, to repress ADAMTS1 expression in the endocardium that overlies the developing trabeculae. PMID: 18267097

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KEGG: mmu:11504

STRING: 10090.ENSMUSP00000023610

UniGene: Mm.1421