Recombinant Mouse Adapter molecule crk (Crk)

1. These results indicate that CCRK functions in eye development by both positively and negatively regulating the Hh pathway, and they reveal distinct requirements for Hh signaling in patterning and morphogenesis of the eyes. PMID: 29166577
2. the data suggest that CCRK positively regulates the kinetics by which ciliary proteins such as Smoothened and Gli2 are imported into the cilium, and that the efficiency of ciliary recruitment allows for potent responses to Hedgehog signaling over long time periods. PMID: 28817564
3. results suggest that Crk and CrkL play essential overlapping roles in fibroblast growth. PMID: 27807028
4. both Crk and CrkL are required for the acquisition of cellular transformation by v-fos, whereas Crk plays a more prominent role than CrkL in v-ras-induced transformation. PMID: 25557916
5. results support a model in which Dok1 phosphorylation normally suppresses localized Ras pathway activity in Crk-transformed cells via recruitment and/or activation of RasGAP PMID: 25043303
6. Differential migration of CRK/CRKL-deficient T cells resulted in efficient graft-versus-leukemia responses with minimal graft-versus-host disease in mice. PMID: 25621495
7. Crk1/2 and CrkL are physically linked, functionally complement each other during podocyte foot process spreading, and together are required for developing typical foot process architecture. PMID: 24499776
8. Data suggest that interactions between Crk (proto-oncogene proteins c-crk) and Sos1 (Son of Sevenless homolog 1) involve electrostatic interactions at binding sites. PMID: 25207671
9. Results suggest that Crk and CrkL have critical roles in cell structure and motility by maintaining cytoskeletal integrity. PMID: 24166500
10. The v-Crk-myosin-1c interaction, which modulates membrane dynamics by regulating Rac1 activity, is crucial for cell adhesion and spreading. PMID: 23983611
11. The authors cloned SH2 domain-containing proteins they named GRBs (for growth factor receptor-bound). They identified GRB-3 as having 77% identity at the protein level and 80% similarity at the DNA level to v-crk. PMID: 1409582
12. The authors cloned and sequenced the avian sarcoma virus CT10 from infected QT6 quail cells then demonstrated that the protein p47 phosphorylates tyrosine residues and can modulate activity of tyrosine kinases. They name the oncogene crk for CT10 regulator of kinase. PMID: 2450282
13. Data show a critical role for Crk and Crk-L downstream from Dok-7 in presynaptic and postsynaptic differentiation. PMID: 21041412
14. SOS1 is essential for CrkI-induced fibroblast transformation, and also reveal a surprising negative role for Abl kinases in Crk transformation. PMID: 20729917
15. This study provides evidence for a potential role of CrkII in integrating signals for breast cancer progression in vivo, which has important implications for elevated CrkII observed in human cancer. PMID: 20008144
16. A 5th member of the Crk family of adaptor proteins, CrkIII, was cloned; it is identical to CrkII until the 2d of its two SH3 domains, which is disrupted partway through, resulting in a nonfunctional domain & a unique C-terminal sequence PMID: 12894221
17. IFN-zeta/limitin induced weaker phosphorylation of Crk and lower induction of Daxx than IFN-alpha PMID: 15781341
18. These data indicate that Crk is involved in cardiac and craniofacial development and that it plays an essential role in maintaining vascular integrity during embryonic development. PMID: 16880535
19. These data suggest that Dock180/ELMO and CrkII act as two evolutionarily conserved signaling submodules that coordinately regulate engulfment. PMID: 17304244
20. CrkII-DOCK180 is also responsible, at least in part, for the effects of Fcgamma receptors implies PMID: 17308335
21. Ab1 functions as a negative regulator of Met-induced cell motility via phosphorylation of the adaptor protein CrkII. PMID: 17399949
22. v-Src tumors exhibited aggressive growth and extensive angiogenesis, while c-Src tumors grew more slowly accompanied by the induction of hematomas. PMID: 18173743
23. The Crk family proteins are important downstream components of the reelin signaling pathway in the regulation of postnatal hippocampal dendritogenesis. PMID: 18477607
24. Crk and CrkL play essential overlapping functions in the Reelin signaling pathway. PMID: 19074029

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KEGG: mmu:12928

STRING: 10090.ENSMUSP00000017920

UniGene: Mm.280125