Recombinant Mouse Adenylate cyclase type 5 (Adcy5), partial

1. AC5 contributes importantly to increased renal cAMP levels and cyst growth in Pkd2 mutant mice, and inhibition of AC5 may be beneficial in the treatment of polycystic kidney disease. PMID: 29042084
2. AC5 mutation produces autistic-like symptoms through the upregulation of mGluR5 functions in the dorsal striatum and that the dorsal striatum regulated by AC5 is a neural correlate responsible for core Autism spectrum disorders symptoms PMID: 27878759
3. Results show that both ATP and Gsalpha binding have significant effects on the structure and flexibility of adenylyl cyclase. New data on ATP bound to AC5 in the absence of Gsalpha notably help to explain how Gsalpha binding enhances enzyme activity and could aid product release. Simulations also suggest a possible coupling between ATP binding and interactions with the inhibitory G-protein subunit Galphai. PMID: 29694437
4. AC5 knockout mice, without exercise training, share similar mechanisms responsible for enhanced exercise capacity with chronic exercise training. PMID: 28887652
5. Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in a model of autosomal dominant polycystic liver disease. PMID: 27826057
6. In this study, we report that in the striatum AC5 exists in a stable pre-coupled complex with subunits of Golf heterotrimer. PMID: 26613416
7. changes in adipose tissue ADCY5 expression are related to obesity and fat distribution. PMID: 25793868
8. these results suggest that AnxA4 is a novel direct negative regulator of AC5, adding a new facet to the functions of annexins. PMID: 26023182
9. These results identify the AC5 and mGluR system in the dorsal striatum as molecular on/off switches to direct decisions on behavioral preferences for cue-oriented options PMID: 25378213
10. deficiency of AC5 protects against obesity, glucose intolerance, and insulin resistance. PMID: 25732192
11. Myocardial adrenergic receptor beta 1 preferentially associates with AC5. PMID: 25677623
12. Disruption of AC5 prevents cardiomyopathy induced by chronically enhanced beta-AR signaling in mice with overexpressed beta-AR, potentially by enhancing resistance to oxidative stress and apoptosis, suggesting a novel, alternative approach to beta-AR blockade. PMID: 25193472
13. AC5 knockout mice delayed age-related tumor incidence significantly. PMID: 23957304
14. These results identify the AC5/cAMP system in the dorsal striatum as a therapeutic target for the treatment of L-DOPA-induced dyskinesia in patients with Parkinson's disease. PMID: 25164669
15. Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle, contributing to colonic dysmotility during inflammation. PMID: 24944202
16. ACV isoform is localized mainly in the t-tubular region of cardiac myocytes where its influence on L-type calcium channels is restricted by phosphodiesterase. PMID: 23609114
17. Overexpression of AC5 exacerbates the cardiomyopathy induced by chronic catecholamine stress by altering regulation of SIRT1/FoxO3a, MEK/ERK, and MnSOD. PMID: 23536361
18. AC5 knockout and caloric restriction mice share many tissue-specific pathways in the regulation of longevity and stress resistance PMID: 23104867
19. The signaling pathway(s) interplayed by AC5, CaMKIIalpha and BDNF within the dorsal striatum is important for regulating the duration of ethanol-induced loss of righting reflex. PMID: 23063718
20. These data provide critical information for AC5 activation as a candidate target for the treatment of alcoholism. PMID: 21193983
21. the unique signaling effects of enhanced beta(2)AR and AC5, which have the potential to afford benefit in heart failure, failed to salvage ventricular function in beta(1)AR-mediated cardiomyopathy. PMID: 20443853
22. AC5 is specifically required for learning associations between discrete cues and outcomes in which the temporal relationship between conditioned stimulus (CS) and unconditioned stimulus (US) is essential PMID: 20189959
23. Ca(2+)-mediated inhibition of AC5/6 is an important mechanism of purinergic receptor-induced decline of cAMP in vascular smooth muscle cells. PMID: 19889965
24. The AC5-associated signal system and neural network are involved in the regulation of anxiety and stress-coping response. PMID: 19405150
25. Type 5 adenylyl cyclase-null mice exhibited Parkinsonian-like motor dysfunction, i.e. abnormal coordination and bradykinesia PMID: 12665504
26. limiting type 5 adenylyl cylase plays a protective role in response to pressure overload and the development of heart failure, potentially through limiting the incidence of myocardial apoptosis PMID: 12904575
27. findings suggest that type 5 adenylyl cyclase does not contribute to striatal cAMP signaling at birth. However, it may play an important role in developmental changes in the expression of Galphaolf, but not Galphas. PMID: 15094058
28. type 5 adenylyl cyclase inhibition prevents myocardial apoptosis PMID: 15262973
29. Suppression of renin release by [Ca2+]i is mediated by an inhibition of adenylate cyclases 5 and 6, resulting in a reduction of intracellular cAMP levels and providing a functional basis for the so-called calcium paradoxon of renin release. PMID: 17068292
30. G protein betagamma subunits stimulate type V and VI adenylyl cyclases PMID: 17110384
31. increased activity of the calcium-inhibitable isoform adenylyl cyclase-V in thejuxtaglomerular cell, produces cAMP, which stimulates renin secretion. PMID: 17190869
32. AC5-/- mice display hypoalgesic responses to inflammatory pain induced by subcutaneous formalin, and to non-inflammatory and inflammatory visceral pain. AC5-/- mice show strongly suppressed mechanical and thermal allodynia. PMID: 17410641
33. These results suggest that AC is a fundamentally important mechanism regulating lifespan and stress resistance. PMID: 17662940
34. The absence of type 5 AC results in more effective desensitization after long-term catecholamine stress and protects against the development of myocyte apoptosis and deterioration of cardiac function PMID: 17893275
35. AC5 plays a major role in stabilizing heart rate under microgravity PMID: 18450980
36. A mouse model has been developed with genetic disruption of adenylyl cyclase type 5, which lives one-third longer than the wild-type and is protected from aging-induced, pressure overload-induced and catecholamine-induced stresses [review] PMID: 19106458
37. AC5 is an important AC isoform in heart. PMID: 19307450
38. The association of AC5 with the AKAP6 complex is required for the regulation of cAMP second messenger controlling cardiac myocyte hypertrophy. PMID: 19574217
39. Cardiac AC5 declines with development and increases with pressure-overload hypertrophy. PMID: 19734365
40. Loss of AC5, an isoform of AC highly expressed in the striatum, severely impairs response and motor skill learning but not spatial learning. AC5-deficient mice are impaired in acquisition of a motor skill, as assessed by the accelerated rotarod. PMID: 19793969

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KEGG: mmu:224129

STRING: 10090.ENSMUSP00000110563

UniGene: Mm.41137