Product Details

Purity

>85% (SDS-PAGE)

Target Names

Mc2r

Uniprot No.

Q64326

Alternative Names

Mc2r; Acthr; Adrenocorticotropic hormone receptor; ACTH receptor; ACTH-R; Adrenocorticotropin receptor; Melanocortin receptor 2; MC2-R

Species

Mus musculus (Mouse)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).

Gene References into Functions

JDP2 acts as a novel transcriptional activator of the mouse Mc2r gene, suggesting that JDP2 may have physiological functions as a novel player in MC2R-mediated steroidogenesis as well as cell signaling in adrenal glands. PMID: 28146118
Data show that neuromedin B (NMB) expression was higher in the melanocortin 2 receptor MC2R(-/-) than in the wild-type (WT) mice. PMID: 24742195
MC2R plays an important role for regular lipolytic function and lipid composition in 3T3-L1 adipocytes. PMID: 22723268
Functional melanocortin-2 receptors are expressed by mouse aorta-derived mesenchymal progenitor cells. PMID: 22306084
melanocortin 2 receptor and melanocortin 5 receptor are lipolytic mediators in differentiated 3T3-L1 adipocytes PMID: 21616121
MC2R+/- pups delivered from MC2R-/- females crossed with MC2R+/+ males mice thrived poorly with MC2R-/- mothers but grew to adulthood when transferred to foster mothers after birth, suggesting that MC2R-/- females are poor mothers or cannot nurse. PMID: 21303938
The promoter activity of Mc2r is activated by FOXL2 in a dose-dependent manner; transcriptional activity of Mc2r is up-regulated by synergistic interaction of FOXL2 and NR5A1. PMID: 20650879
MC2R in Y1 cells internalizes by a G protein coupled receptor kinase dependent clathrin-coated pit mechanism. PMID: 12530627
Data show that adrenocorticotrophic hormone resistance in tumor cell mutants is associated with a base change polymorphism in the steroidogenic factor 1 gene. PMID: 12851310
Novel 135-bp exon 1f of ACTH-R gene was located 1.4 kb downstream in genome of exon 1a transcribed in adrenal gland. Promoter region flanking to exon 1f may be essential for adipose tissue; that flanking to exon 1a is specific for the adrenal gland. PMID: 15004405
a novel mechanism for mc2-r transcription, which may have significance in both adrenal and extra-adrenal sites of expression PMID: 15028712
Mc2r expression is associated with a less aggressive tumor phenotype and anti-proliferative effects can be amplified through stimulation with physiological doses of ACTH. PMID: 16131607
A CCAAT/enhancer-binding protein binding site, 87 bp upstream of the transcriptional initiation site, is necessary for the activity of Mc2R promoter. PMID: 16997835
MC2-R gene is regulated both transcriptionally and post-transcriptionally during adipogenesis PMID: 17170082
MC2R is required for postnatal adrenal development and adrenal steroidogenesis and that MC2R KO mice provide a useful animal model by which to study familial glucocorticoid deficiency PMID: 17989225
The melanocortin 2 receptor accessory protein exists as a homodimer and is essential for the function of the melanocortin 2 receptor in the mouse y1 cell line. PMID: 18162519
MRAP not only facilitates MC2 receptor trafficking but also allows properly localized receptor to bind ACTH and consequently signal. PMID: 18981183
Results describe the phenotype of mice deficient in melanocortin 2 receptor on a B6/Balbc mix background. PMID: 19022343
The results establish that MRAP forms stable complexes with two different melanocortin receptors, facilitating surface expression of MC2 receptor but disrupting dimerization and surface localization of MC5 receptor. PMID: 19535343

Hide All

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 1 family

Database Links

KEGG: mmu:17200

STRING: 10090.ENSMUSP00000058691

UniGene: Mm.426053

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：
If CAPTCHA verification fails, click to refresh the CAPTCHA and try again.

Code	CSB-YP723737MO1
MSDS	MSDS Datasheet
Size	Pls inquire
Source	Yeast
Have Questions?	Leave a Message or Start an on-line Chat

Code	CSB-EP723737MO1
MSDS	MSDS Datasheet
Size	Pls inquire
Source	E.coli
Have Questions?	Leave a Message or Start an on-line Chat

Code	CSB-EP723737MO1-B
MSDS	MSDS Datasheet
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
Have Questions?	Leave a Message or Start an on-line Chat

Code	CSB-BP723737MO1
MSDS	MSDS Datasheet
Size	Pls inquire
Source	Baculovirus
Have Questions?	Leave a Message or Start an on-line Chat

Code	CSB-MP723737MO1
MSDS	MSDS Datasheet
Size	Pls inquire
Source	Mammalian cell
Have Questions?	Leave a Message or Start an on-line Chat

Recombinant Mouse Adrenocorticotropic hormone receptor (Mc2r), partial

Product Details

Related Products

Customer Reviews and Q&A

Target Background

×CloseMessage