MC2R

MC2R encodes the Melanocortin 2 Receptor, also commonly known as ACTH receptor. This protein is a G - protein coupled receptor mainly expressed in the adrenal cortex. It binds to adrenocorticotropic hormone (ACTH), initiating a signaling cascade through the G - s protein, which activates adenylate cyclase, increasing intracellular cAMP levels.
MC2R is involved in the hypothalamic - pituitary - adrenal axis. Mutations in MC2R can lead to familial glucocorticoid deficiency. In terms of drug development, there is ongoing research to find agonists or antagonists that can precisely modulate its function for treating adrenal - related disorders.