Recombinant Mouse Atrial natriuretic peptide receptor 1 (Npr1), partial

1. A decreased Npr1 copy number enhanced the expression of hypertrophic markers. PMID: 27199456
2. The results indicate that the inhibition of NPRA suppresses gastric cancer development and targeting NPRA may represent a promising strategy for the treatment of gastric cancer. PMID: 27634171
3. KLF10 and atrial natriuretic peptide/NPRA in exerting influences on chronic pulmonary disease pathogenesis PMID: 27592451
4. Treatment of the haplotype Npr1(+/-) mice with histone deacetylase inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1/2, NF-kappaB (p65), and STAT1. PMID: 28566502
5. The results suggest that an antagonistic cascade exists between the TGF-beta1/Smad/deltaEF1 pathways and Npr1 expression and receptor signaling that is relevant to renal and vascular remodeling, and may be critical in the regulation of blood pressure and cardiovascular homeostasis. PMID: 26934489
6. Conclude that postnatal cardiac hyperplasia in mice with global GC-A inactivation is provoked by systemic alterations rather than direct regulation of cardiac myocyte proliferation. PMID: 26059418
7. Suggest that the FQQI motif is essential for the internalization and subcellular trafficking of NPRA during the hormone signaling process in intact mesangial cells. PMID: 26377794
8. Data suggest activation of skeletal muscle (SM) Npra is important for maintenance of long-term insulin sensitivity; up-regulation of Npra signal transduction in SM (that was reduced by obesity) prevents glucose intolerance and diabetes type 2. PMID: 26253614
9. these findings define a novel epigenetic regulatory mechanism that governs Npr1 gene transcription. PMID: 24451378
10. Npr1 represses the expression of cardiac proinflammatory mediators, hypertrophic markers, and NF-kappaB/AP-1-mediated mechanisms, which seem to be associated in an Npr1 gene-dose-dependent manner PMID: 24424043
11. ANP is capable of attenuating agonist-induced lung edema in the absence of NPR-A. PMID: 23195629
12. These results demonstrate that a high-salt diet aggravates cardiac ANG II, aldosterone and pro-inflammatory cytokine levels in Npr1 gene-disrupted 1-copy mice, whereas, in Npr1 gene-duplicated (3-copy and 4-copy) mice, high salt did not render such elevation, suggesting the potential roles of Npr1 against salt loading. PMID: 23188418
13. ANP-NPRA system exerts an inhibitory effect on MAPKs and down-stream effector molecules, AP-1, and CREB, critical for cell growth and proliferation. PMID: 22610792
14. Natriuretic peptide receptor guanylyl cyclase-A protects podocytes from aldosterone-induced glomerular injury. PMID: 22652704
15. Results demonstrate the opposite effects of NPR-A and NPR-C in LPS-mediated endothelial permeability and lung injury. PMID: 22001395
16. Data suggest that a NPPA gradient originating in the oviduct induces sperm chemotaxis by binding to its receptor NPR1 and then activating PKG pathway, and plays a physiological role in fertilization. PMID: 21809340
17. Cellular exposure to Go6976 reduced basal and natriuretic peptide-dependent, but not detergent-dependent, GC-A and GC-B activity. PMID: 21366551
18. NPR-A regulates self-renewal and pluripotency of embryonic stem cells. PMID: 21390061
19. Soluble guanylyl cyclase alpha1 subunit is important in penile erection in mice. PMID: 20098992
20. The present results demonstrate that the disruption of Npr1 gene activates proinflammatory cytokines leading to fibrosis, hypertrophic growth, and remodeling of the kidneys of mutant mice. PMID: 20881240
21. Trans retinoic acid activation of Npr1 gene transcription is mediated through binding of Ets-1 and Sp1 to the Npr1 promoter. PMID: 20864529
22. Suggest that NPR-A activation by natriuretic peptides facilitates iNOS expression and contributes to the vascular dysfunction characteristic of endotoxic shock. PMID: 20649600
23. results suggest that particulate matter and O3 exposures, alone and combined, lead to different cardiac functional changes, and these unique changes are age-specific and dependent on Nppa and Npr1 genes PMID: 20540624
24. The ANP/GC-A system may have a modulating effect on beta-cell function. PMID: 20555029
25. The Stria vascularis may be the most important place for ANP to regulate endolymph fluid balance via NPR-A. PMID: 20150880
26. The ANP/NPR-A signaling pathway is upregulated in streptozotocin-induced diabetic mice, and contributes to the development of diabetic gastroparesis. PMID: 20039448
27. Mice lacking a functional NPR-A receptor represent a useful model to study the role of the ANP system in alcohol-associated pathology. PMID: 19828462
28. two distinct NPR-A phosphatase activities PMID: 11821394
29. NPR1 is an atherosclerosis susceptibility locus and represents a potential link between atherosclerosis and cardiac hypertrophy. Npr1 has a role in regulation of hypertrophic cell growth. PMID: 12702516
30. Results suggest a local function of the atrial natriuretic peptide receptor guanylyl cyclase-A system to moderate the molecular program of cardiac hypertrophy. PMID: 12727932
31. NPRA activation is the predominant mechanism mediating the natriuretic, diuretic, and renal hemodynamic responses to acute blood volume expansion. PMID: 12824076
32. NPRA receptor has a role in attenuating the effects of hypertrophic agents on cardiac wall thickness and in cardiac hypertrophy PMID: 14500707
33. suggest that androgens contribute to gender-related differences in cardiac hypertrophy and fibrosis by a mechanism involving angiotensin II type 1A receptor (AT1A) receptors and guanylyl cyclase-A PMID: 14592959
34. The combination of increased CaMKII activity and altered action potential characteristics facilitates ventricular arrhythmias in hypertrophic GC-A-/- hearts PMID: 15135664
35. circulating ANP levels and data from NPR1(-/-) and NPR3(-/-) mice suggest that the ANP pathway may not be involved in the cardiovascular response to caloric restriction PMID: 15191892
36. Acute renal and mean arterial pressure responses to atrial extracts require the NPRA receptor. PMID: 15337836
37. ablation of NPRA/cGMP signaling activates NF-kappaB binding activity associated with hypertrophic growth of mutant mice hearts PMID: 15629436
38. ATP does not activate NPRA and NPRB as has been repeatedly reported. Instead, ATP increases activity primarily by maintaining proper receptor phosphorylation status but also serves a previously unappreciated enzyme stabilizing function. PMID: 15911610
39. Guanylyl cyclase-A activation by endogenous cardiac natriuretic peptides protects against acute heart failure and attenuates chronic cardiac remodeling after myocardial infarction, mediated partly through inhibition of renin-angiotensin system. PMID: 15998711
40. Enhanced activity of the myocardial Na+/H+ exchanger NHE-1 moderates the cardiac growth response to pressure overload in atrial natriuretic peptide receptor-deficient mice. PMID: 16216978
41. Ets-1 greatly stimulates Npr1 gene promoter activity, implicating its critical role in the regulation and function of NPRA at the molecular level PMID: 16517010
42. ANG II-dependent transcriptional repression of Npr1 gene promoter activity and down-regulation of GC activity of translated protein, NPRA, is regulated by PKC pathways PMID: 16930545
43. Reduced NPR-A protein levels, not receptor dephosphorylation, explain the renal hyporesponsiveness to natriuretic peptides in congestive heart failure. PMID: 17264312
44. Findings provide direct evidence that ablation of NPRA/cGMP signaling activates inflammatory cytokines, probably via NF-kappaB mediated signaling pathway, and is associated with hypertrophic growth of null mutant hearts. PMID: 17267074
45. Mediates cardiomegaly by its effect on two different gene pathways. PMID: 17293444
46. increased adrenal ANG II and Aldo levels lead to renal and vascular injury in Npr1 gene-disrupted mice PMID: 17389676
47. Disruption of NPRA/cGMP signaling leads to the augmented expression of cardiac renin-angiotensin pathways causing cardiac hypertrophy and remodeling. PMID: 17566078
48. ATP is not required for the initial activation of natriuretic peptide receptor A and B, but does increase activity over time by reducing the apparent K(m) for GTP. PMID: 17848634
49. These results suggest that NPRA is involved in tumor angiogenesis. PMID: 18172317
50. Lung ischemia reperfuion injury triggers atrial natriuretic peptide release and alters endothelial signaling to activate NPR-A. PMID: 18223163

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KEGG: mmu:18160

STRING: 10090.ENSMUSP00000029540

UniGene: Mm.4627