Recombinant Mouse Bone morphogenetic protein 5(Bmp5)

Code CSB-YP002741MO
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Source Yeast
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Code CSB-EP002741MO
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Source E.coli
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Code CSB-EP002741MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP002741MO
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Source Baculovirus
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Code CSB-MP002741MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Bmp5
Uniprot No. P49003
Alternative Names Bmp5; Bmp-5; Bone morphogenetic protein 5; BMP-5
Species Mus musculus (Mouse)
Expression Region 315-452
Target Protein Sequence AASKRK NQNRNKSNSH QDPSRMPSAG DYNTSEQKQA CKKHELYVSF RDLGWQDWII APEGYAAFYC DGECSFPLNA HMNATNHAIV QTLVHLMFPD HVPKPCCAPT KLNAISVLYF DDSSNVILKK YRNMVVRSCG CH
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Induces cartilage and bone formation.
Gene References into Functions
  1. Data conclude that BMP-5 has stage-specific role to play during MC3T3E1 osteoblast differentiation in part by autocrine p38/Runx2/COLIA1 signaling. PMID: 28497879
  2. Bmp5 gene thus contains an "injury response" control region that is distinct from embryonic enhancers, and that is activated by multiple types of injury in adult animals PMID: 25886903
  3. Early endothelial outgrowth cells act protective in diabetic nephropathy, and such effects are significantly stimulated by BMP-5 PMID: 25080521
  4. BMP-5 acts as a potent endothelial outgrowth cells agonist in murine AKI in the short and mid to long term PMID: 23678046
  5. Bone morphogenetic protein 5 regulates the number of keratinocyte stem cells from the skin of mice. PMID: 21179110
  6. Data indicate that locus coeruleus development requires either Bmp5 or Bmp7, and one is able to compensate for the loss of the other. PMID: 20493948
  7. Variability in gene expression of BMP5 may be an important contributor to osteoarthritis genetic susceptibility PMID: 20021689
  8. BMP5 is required not only for skeletal patterning during embryonic development, but also for bone response and remodeling to mechanical stimulation at specific anatomic sites in the skeleton PMID: 18380899
  9. Bmp5 is expressed in many skeletal precursors and different enhancers control expression in individual bones. PMID: 19096511

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Subcellular Location Secreted
Protein Families TGF-beta family
Database Links

KEGG: mmu:12160

STRING: 10090.ENSMUSP00000012281

UniGene: Mm.428950

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