Recombinant Mouse Bone morphogenetic protein receptor type-2(Bmpr2),partial

Code CSB-YP002752MO
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Source Yeast
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Code CSB-EP002752MO
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Source E.coli
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Code CSB-EP002752MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP002752MO
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Source Baculovirus
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Code CSB-MP002752MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Bmpr2
Uniprot No. O35607
Alternative Names Bmpr2Bone morphogenetic protein receptor type-2; BMP type-2 receptor; BMPR-2; EC 2.7.11.30; BRK-3; Bone morphogenetic protein receptor type II; BMP type II receptor; BMPR-II
Species Mus musculus (Mouse)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6
Gene References into Functions
  1. High BMPR2 expression is associated with aberrant synaptic development in mouse and Drosophila models of Fragile X syndrome. PMID: 28465421
  2. BMPR2 deletion extended survival relative to Pten deletion alone, establishing its promoting role in BMP6-driven prostate cancer progression PMID: 29352019
  3. Dual luciferase report assay verified that miR-3065-5p could bind to the 3'UTR of bone morphogenetic protein receptor type II (BMPR2), which dramatically increased in the beginning of odontoblastic differentiation but decreased in the terminal differentiation stage. PMID: 29127007
  4. increased BMPR2 signal transduction is linked to fragile X syndrome (FXS) and that the BMPR2-LIMK1 pathway is a putative therapeutic target in patients with FXS and possibly other forms of autism PMID: 27273096
  5. Disrupting BMPR2 impairs TGFbeta1- and BMP4-mediated elastic fiber assembly and is of pathophysiologic significance in pulmonary arterial hypertension. PMID: 28619995
  6. These results suggested that endogenous PTH enhanced BMPR2 expression by a cAMP/PKA/CREB pathway in osteoblasts, and increased RUNX2 expression through transduction of the BMP/pSMAD1/5/8 signaling pathway PMID: 28578352
  7. Cav-1 depletion, oxidative stress-mediated reduction in BMPRII expression, and enhanced TGF-beta-driven SMAD-2/3 signaling promote pulmonary vascular remodeling in inflamed lungs. PMID: 28188225
  8. BMPR2 gene transfer reduced TGF-beta effects on Smad2, Smad1/5/8 and Erk1/2 phosphorylation in human pulmonary arterial smooth muscle cells PMID: 26689975
  9. loss in hippocampus and forebrain impacts exploratory and anxiety-related behaviors PMID: 26444546
  10. Deleting Bmpr2 in mouse skeletal progenitor cells impaired activin signaling resulting in an increased bone formation rate and high bone mass. PMID: 25663702
  11. The findings suggest that the mutant ALK2 related to Fibrodysplasia ossificans progressiva is enhanced by bone morphogenetic protein type II receptors via the T203-regulated phosphorylation of ALK2. PMID: 25354296
  12. BMPR2 has tumor suppressive functions in the stroma by regulating inflammation. PMID: 25205038
  13. Serotonin can increase ERalpha expression in human pulmonary arterial smooth muscle cells and antagonism of oestrogen receptor alpha reverses serotonin-dependent PH in the mouse and increases bone morphogenetic protein receptor type 2 expression PMID: 25765937
  14. BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension. PMID: 25863249
  15. Members of the miR-17 family influence gastrulation by suppressing Bmpr2 expression at the primitive streak. PMID: 25209090
  16. Mutations in BMPR2 underlie most heritable cases and a small proportion of sporadic cases of idiopathic pulmonary arterial hypertension. PMID: 26030479
  17. BMP9 is identified as the preferred ligand for preventing apoptosis and enhancing monolayer integrity in endothelial cells from subjects with pulmonary arterial hypertension who bear mutations in the gene encoding BMPR2. PMID: 26076038
  18. These data suggest that heterozygous null BMPR2 mutations promote SRC-dependent caveolar trafficking defects in PECs and that this may contribute to pulmonary endothelial barrier dysfunction in Hereditary pulmonary arterial hypertension patients PMID: 25411245
  19. BMPR2 expression potentiated activin A responses whereas depletion of endogenous BMPR2 with short interfering RNAs attenuated activin A-stimulated follicle-stimulating hormone beta transcription in gonadotrope-like cells. PMID: 24018044
  20. BMP type II receptors, BMPR2 and ActR2a, have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism. PMID: 25075125
  21. Data indicate that mice with heterozygous mutant bone morphogenetic protein (BMP) type II receptor (BMPR2) grew normally without developing pulmonary arterial hypertension. PMID: 24116187
  22. data indicate that the endogenous NMD negative BMPRDeltaEx2 mutant product is expressed but has a folding defect resulting in ER retention. PMID: 24224048
  23. reduced BMPR2 can subvert a stress granule response, heighten GM-CSF mRNA translation, increase inflammatory cell recruitment, and exacerbate pulmonary arterial hypertension PMID: 24446489
  24. Impaired right ventricle (RV) hypertrophy was associated with triglyceride deposition in mice with mutant Bmpr2 expression in RV. Human RVs with heritable pulmonary arterial hypertension showed lipid deposition and alteration in fatty acid oxidation. PMID: 24274756
  25. Hyperoxia synergizes with Bmpr2 mutations to cause metabolic stress, oxidant injury, and pulmonary hypertension. PMID: 23742019
  26. In mice with conditional endothelial cell Bmpr2 deletion, low-dose FK506 prevented exaggerated chronic hypoxic pulmonary hypertension. PMID: 23867624
  27. Abnormalities in uterine BMPR2-mediated signaling pathways can have catastrophic consequences in women for the maintenance of pregnancy. PMID: 23676498
  28. Bmpr2 and Acvr2a normally play cell-type-specific, necessary roles in organelle biogenesis and the shutdown of developmental programs and cell division. PMID: 22611050
  29. BMPR-II dysfunction promotes the activation of small mothers against decapentaplegia-independent mitogen-activated protein kinase pathways via TGFbeta-associated kinase 1, resulting in a pro-proliferative and anti-apoptotic response PMID: 22388934
  30. BMPR-II is not required for endochondral ossification in the limb where loss of BMPR-II may be compensated by BMP utilization of Acvr2a and Acvr2b. PMID: 21538804
  31. Functional redundancy in osteoblast differentiation is observed between bone morphogenetic protein receptor BMPR-II and activin receptor ActR-IIB. PMID: 21503889
  32. The expression of Bmpr2 in the proximal outflow tract septum was delayed in CX43 knockout mice. PMID: 22094042
  33. cytoskeletal defects are common to multiple BMPR2 mutations and are associated with activation of the Rho GTPase, Rac1 PMID: 22180660
  34. BMPR2 has tumor-suppressive function in mammary epithelia and microenvironment and that disruption can accelerate mammary carcinoma metastases. PMID: 21576484
  35. CXCR1/2 pathway antagonists may represent a novel therapeutic approach for treating pulmonary hypertension because of defects in BMPR-II expression. PMID: 21900197
  36. Bmpr2 mutation in endothelial cells may drive pulmonary arterial hypertension through multiple, potentially independent, downstream mechanisms, including proliferation, apoptosis, inflammation, and thrombosis. PMID: 21696628
  37. Data describe a BMPR2-mediated transcriptional complex between PPARgamma and beta-catenin, and suggest that apelin could be effective in treating PAH by rescuing BMPR2 and PAEC dysfunction. PMID: 21821917
  38. findings confirm ET-1 and its receptors are present in lung macrophages; ETA and ETB receptor expression is decreased in bone marrow-derived macrophages from a BMPR2 mutant mouse model of heritable pulmonary artery hypertension compared with controls PMID: 20562228
  39. An in vivo tool to study the role of BMPRII in BMP/Smad signaling and the regulation of this pathway by PTH and Wnts. PMID: 20392248
  40. Bone morphogenetic protein 7 rapidly activates c-Jun N-terminal kinases (JNKs), and JNKs associate with the carboxy terminus of the BMP receptor, BMPRII. PMID: 20176805
  41. Loss of BMPRII signaling in smooth muscle is sufficient to produce the pulmonary hypertensive phenotype. PMID: 15031260
  42. Mutation of one copy of the BMPR-II gene causes pulmonary hypertension but impairs the ability of the pulmonary vasculature to remodel in response to prolonged hypoxic breathing. PMID: 15286002
  43. Results define a pathway linking the bone morphogenetic protein receptor BMPRII to regulation of actin and provides insights into how extracellular signals modulate LIMK1 activity during dendritogenesis. PMID: 15538389
  44. loss of Bmpr2 leads to the net gain of signaling by some, but not all, BMP ligands via the activation of ActRIIa PMID: 15883158
  45. Our data suggest that the complex formation between c-kit and BMPR-II leads to phosphorylation of BMPR-II at Ser757, which modulates BMPR-II-dependent signaling PMID: 16155937
  46. BMP pathway regulates IL-6 in pulmonary tissues and conversely that IL-6 regulates the BMP pathway PMID: 17322283
  47. relevance of BMPR2 dysregulation may extend beyond proliferation in idiopathic pulmonary artery hypertension PMID: 17369292
  48. identified the receptor for activated C-kinase (RACK1) as a novel interaction partner of BMPRII by yeast 2-hybrid analyses using the kinase domain of BMPRII as a bait. PMID: 17515463
  49. Inactivation in the stroma leads to epithelial hyperplasia throughout the colon with increased epithelial cell proliferation; mutant mice develop rectal bleeding and hamartomatous polyps in the colorectum. PMID: 17700526
  50. Pulmonary endothelium is a target of abnormal Bmpr2 mutant mice, suggesting that endothelial dysfunction contributes to increased susceptibility to hypoxic pulmonary hypertension. PMID: 18024717

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Subcellular Location Cell membrane, Single-pass type I membrane protein
Protein Families Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
Database Links

KEGG: mmu:12168

STRING: 10090.ENSMUSP00000084701

UniGene: Mm.391654

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