Recombinant Mouse Calcium-activated potassium channel subunit beta-1 (Kcnmb1), partial

1. Whole-cell currents density of BK channels and amplitude of spontaneous transient outward currents were significantly reduced in hypoxia vascular myocytes. PMID: 29486465
2. Study showed that in human and rat arterial myocytes, membrane depolarization rapidly increased the cell surface abundance of auxiliary BK beta1 subunits but not that of the pore-forming BKalpha channels. Membrane depolarization stimulated voltage-dependent Ca(2+) channels, leading to Ca(2+) influx and the activation of Rho kinase (ROCK) 1 and 2. PMID: 28487419
3. Expression of vascular large-conductance calcium-activated potassium channel Kcnmb1 is regulated by Nrf2 signaling. PMID: 28429615
4. 7-Ketocholesterol induces the reduction of KCNMB1 through the AhR pathway. PMID: 25576871
5. BK channel activity directly affects vascular tone but influences blood pressure independent of this effect via different pathways PMID: 24687584
6. up-regulation of NF-kappaB-dependent MuRF1 expression is a novel mechanism that leads to BK channelopathy and vasculopathy in diabetes PMID: 24570002
7. Our results support a model whereby subcellular anchoring of CaN by AKAP150 is a key molecular determinant of vascular BKCa channel remodeling, which contributes to vasoconstriction during diabetes mellitus. PMID: 24323672
8. The activity of BKbeta1 is higher in cerebral smooth muscle cells compared to pulmonary artery. PMID: 23426969
9. The results indicate that the beta1-subunit can form a tripartite complex with TP and MaxiKalpha, has the ability to associate with each protein independently. PMID: 23255603
10. BK channels play a prominent role in smooth muscle function only in the distal colon of mice. Defects in smooth muscle BK channel function disrupt colonic motility causing constipation. PMID: 22830588
11. Impaired sodium excretion resulting form loss of normal purinergic regulation of ENaC in BK-beta4 null mice likely contributes to their elevated blood pressure PMID: 23002235
12. Vascular smooth muscle cell cholesterol and BK beta1 are both required for ethanol inhibition of BK and resulting cerebral artery constriction, with health-related implications for manipulating cholesterol levels in alcohol-induced cerebrovascular disease. PMID: 21868700
13. these results suggested that oxidative stress inhibited Akt signaling and facilitated the FOXO-3a/FBXO-dependent BK-beta(1) degradation in diabetic vessels. PMID: 22586590
14. Reduced vascular BK channel function does not protect against hypotension in the early stage of septic shock; in the later stage, smooth muscle BK channel deficiency enhances organ damage and mortality PMID: 21997262
15. BKbeta4 and to a lesser degree BKbeta1 transcripts and protein are detected in several astrocytic populations and cultured cells. PMID: 21438011
16. enhanced tracheal contraction of the BK beta1 knockout can be ascribed to a defect in BK channel opposition of M2 receptor-mediated contractions PMID: 21300746
17. The results indicate that BK beta1-KO mice are not hypertensive on normal or high-salt intake PMID: 21131476
18. Results reveal the first ion channel subunit as a direct target of SRF-MYOCD transactivation, providing further insight into the role of MYOCD as a master regulator of the SMC contractile phenotype. PMID: 19801679
19. The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1 PMID: 11994272
20. the beta1-subunit of BK(Ca) contributes to the increased glomerular filtration rate that accompanies an acute salt and volume load and raises the possibility that it is also involved in regulating K(+) excretion under these conditions PMID: 12620927
21. BK channels have a central role in urinary bladder function PMID: 15184377
22. the BK-beta1 accessory subunit is present in the connecting tube segment of the mammalian distal nephron and has a significant role in the kaliuretic response to increased urinary flow induced by volume expansion. PMID: 15613616
23. the effect of tamoxifen on arterial KCa channels does not depend on the presence of the beta1 subunit PMID: 15826942
24. Although the functional interaction of alpha and beta1 requires the N-terminal tail of alpha, the physical association requires the S1, S2, and S3 transmembrane helices of alpha PMID: 16549765
25. Beta1-subunit is required in airway smooth muscle for control of voltage-dependent Ca2+ influx during rest and after cholinergic signaling in BK channels. PMID: 16632519
26. Deglycosylation of BK channels did not affect the conductance but shifted the steady-state voltage of activation toward more positive potentials without affecting slope when Ca(2+) concentration was <1 microM. PMID: 16738006
27. Report role of BKbeta1 in Na+ reabsorption by cortical collecting ducts of Na+-deprived mice. PMID: 19458125
28. adaptation to hypoxia exerts a protective role on cardiomyocytes subjected to ischemia and that, unexpectedly, this form of preconditioning absolutely depends on Hif-2alpha. PMID: 19461047
29. The majority of the hypertension of Kcnmb1(-/-) is due to aldosteronism, resulting from renal potassium retention and hyperkalemia. PMID: 19556540

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KEGG: mmu:16533

STRING: 10090.ENSMUSP00000020362

UniGene: Mm.6206