Recombinant Mouse Calcium/calmodulin-dependent protein kinase type II subunit delta (Camk2d)

1. surgical-induced Osteoarthritis mice treated with a miR-146a inhibitor significantly alleviated the destruction of articular cartilage via targeting Camk2d and Ppp3r2. PMID: 28383548
2. we demonstrate that the deltaC isoform of CaMKII contributes significantly to myocardial damage following ex vivo I/R. Signaling occurs through NF-kappaB and TNF-alpha and acute inhibition of the generation or function of thesemolecules has a very robust protective effect inWT animals and in those expressing CaMKIIdeltaC. PMID: 28077321
3. Phosphorylating Titin's Cardiac N2B Element by ERK2 or CaMKIIdelta Lowers the Single Molecule and Cardiac Muscle Force PMID: 26682816
4. CaMK2d-dependent phosphorylation of RyR2-S2814 is significant in cardiomyopathy, independent of hypertrophy, induced by prolonged beta-adrenergic receptor stimulation. PMID: 26080362
5. Data indicate that combined cardiomyocyte-specific deletion of CaM Kinase II CaMKIIdelta/gamma does not affect ischemia/reperfusion (I/R) injury. PMID: 25193973
6. CaMKIIdelta activation and phosphorylation of downstream targets was enhanced in aromatase knockout hearts subjected to ischemia-reperfusion PMID: 25625588
7. Oxidative stress was elevated in mitochondria from Gq versus wild-type mice and respiratory rates were lower; these changes in mitochondrial function were restored by CaMKIIdelta deletion. PMID: 25605649
8. Cardiac CaM Kinase II genes delta and gamma contribute to adverse remodeling but redundantly inhibit calcineurin-induced myocardial hypertrophy. PMID: 25124496
9. Reveal a novel in vivo function of CaMKIIdelta in regulating H3 phosphorylation and suggest a novel epigenetic mechanism by which CaMKIIdelta controls cardiac hypertrophy. PMID: 25421395
10. CaMKIIdeltagamma couples noncanonical Wnt signaling to histone deacetylase 4 and myosin enhancer factor 2. PMID: 25489064
11. developed an ionic model of the ventricular myocyte to interrogate potentially arrhythmogenic positive feedback in both control conditions and when CaMKIIdeltaC is overexpressed PMID: 24421356
12. we show selective upregulation of CaMKIIdelta in adult cardiac fibroblasts following cardiac hypertrophy and assign a previously unrecognised role to CaMKII in regulating adult cardiac fibroblast function in normal and diseased mouse hearts. PMID: 23881186
13. Camk2d expression and activity increase during arteriogenesis PMID: 23951185
14. Our studies suggest that CaMKII is a molecular signal that couples increased reactive oxygen species with atrial fibrillation and that therapeutic strategies to decrease oxidized CaMKII may prevent or reduce it. PMID: 24030498
15. CaMKII activation may not be required for abnormal impulse induction in stretched ventricular myocytes. PMID: 23279377
16. can be phosphoryalated by CaMKIId, both in vitro and in vivo. PMID: 23220127
17. Activation of a mitochondrial/ox-CaMKII pathway contributes to increased sudden death in diabetic patients after myocardial infarction. PMID: 23426181
18. Phosphorylation at specific PEVK/titin N2B-unique sequence sites was decreased in CAMK2g/d double knockout mice. PMID: 23283722
19. CaMKIIdelta exhibited consistent expression patterns between its mRNA and protein with both rising remarkably during osteoclastogenesis PMID: 22428553
20. These results demonstrate that there are dramatic CaMKII-mediated effects on RyR Calcium release that occur via regulation of both RyR activation and termination processes. PMID: 22713561
21. these results indicate that CaMKIIdelta2 downregulates insulin gene expression by Ser142 phosphorylation of CREB and reducing binding of CREB to CBP. PMID: 22554507
22. Abnormality in beta-adrenergic-PKA signaling may contribute to cardiomyopathy and heart failure through dysregulation in the alternative splicing of CaMKIIdelta exons 14, 15, and 16 and up-regulation of CaMKIIdeltaC. PMID: 22132070
23. Na(v)1.5-dependent increase in Na(+influx activates CaMKII, which in turn phosphorylates Na(v)1.5, further promoting Na(+) influx. Pharmacological inhibition of either CaMKII or Na(v)1.5 ameliorates cardiac dysfunction caused by excessive Na(+) influx. PMID: 21677263
24. Data show that Pcp4 overexpression induces precocious neuronal differentiation, and is associated with an increase in CaMKIIdelta activation. PMID: 21491429
25. In cardiomyocytes, [Ca2+]i-activated calmodulin kinase II (CaMKII) activates downstreamregulatory element (DRE) binding transcription factor DREAM, which consequently suppresses the expression of L-type calcium channel 1C-subunit gene (Cacna1c). PMID: 21486818
26. overexpression induces diastolic dysfunction and arrhythmogenic triggers possibly via an enhanced late Na(+) current PMID: 21174213
27. The multifunctional Ca2+/calmodulin-dependent kinase II delta (CaMKIIdelta) controls neointima formation after carotid ligation and vascular smooth muscle cell proliferation through cell cycle regulation by p21. PMID: 21193397
28. CaMKIIdeltac overexpression in RyR2(R4496C+/-) knock-in mice increases the propensity toward triggered arrhythmias, which may impair survival. CaMKII contributes to further destabilization of a mutated RyR2 receptor. PMID: 21251589
29. Camk2delta is poorly expressed in synaptic sites and may be critical for receptor recycling, by providing a mechanism by which postsynaptic acetylcholine receptor density is maintained at the neuromuscular junction in vivo. PMID: 20844140
30. CaMKIIdelta plays a critical role in the development of heart failure in part by accumulation of p53 and induction of cardiomyocyte apoptosis in the dilated cardiomyopathy mouse model PMID: 20713897
31. Mice engineered with an RyR2-S2814A mutation have RyR2 channels that cannot be phosphorylated by CaMKIIdelta, and exhibit a blunted positive force frequency relationship. PMID: 20479242
32. This work has provided insight into the intracellular signaling pathways and transcription factors regulating Ncx1 gene expression in a chronically beta-AR-stimulated heart. PMID: 19945464
33. Data indicate that cardiomyocytes from PLN-KO/CaMKII-TG mice showed poor viability, improved by inhibiting SR Ca(2+) release and mitochondrial Ca(2+) loading. PMID: 19959778
34. role in cell communication PMID: 11889801
35. Delta CaMK-II plays an important role in axonal development in embryonic cells. PMID: 12526889
36. CaMKII is a downstream signal in CAN cardiomyopathy, and increased CaMKII activity contributes to cardiac dysfunction, arrhythmia susceptibility, and longevity during Ca2+-dependent phosphatase calcineurin overexpression. PMID: 16982937
37. Interaction of calcium/calmodulin-dependent protein kinase IIdeltaC with sorcin indirectly modulates ryanodine receptor function in cardiac myocytes. PMID: 17707398
38. In mouse and rabbit myocytes overexpressing CaMKIIdelta(C) by means of adenovirus-mediated gene transfer, recovery of fractional shortening and Ca transients was not impaired during late acidosis but even slightly improved. PMID: 17950750
39. the data demonstrate a dynamic mechanism for CaMKII activation by oxidation and highlight the critical importance of oxidation-dependent CaMKII activation to AngII and ischemic myocardial apoptosis. PMID: 18455987
40. The cloned, expressed CAMK2delta protein comigrated with D52 kinase and colocalized with D52 protein in T84 and HEK293 cells. These findings support a role for CAMK2delta in the mediation of D52 phosphorylation PMID: 18832449
41. insulin regulates Myo1c function via CaMKII-dependent phosphorylation, and these events play a role in insulin-regulated GLUT4 PMID: 19046570
42. the delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload PMID: 19179290
43. CaMKIIdelta contributes to cardiac decompensation by enhancing RyR2-mediated sarcoplasmic reticulum Ca2+ leak and that attenuating CaMKIIdelta activation can limit the progression to heart failure. PMID: 19381018
44. CaMKII has both acute regulatory effects and chronic expression level effects on I(to) and I(K1) with complex consequences on cardiac myocyte action potential PMID: 19808479

Show More

Hide All

KEGG: mmu:108058

UniGene: Mm.255822