CAMK2D Research Reagents

Calcium/calmodulin-dependent protein kinase type II subunit delta is a protein in humans that is encoded by CAMK2D gene. Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program.

The following CAMK2D reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CAMK2D Antibodies

CAMK2D Antibodies for Homo sapiens (Human)

CAMK2D Proteins

CAMK2D Proteins for Oryctolagus cuniculus (Rabbit)

CAMK2D Proteins for Rattus norvegicus (Rat)

CAMK2D Proteins for Homo sapiens (Human)

CAMK2D Proteins for Bos taurus (Bovine)

CAMK2D Proteins for Gallus gallus (Chicken)

CAMK2D Proteins for Mus musculus (Mouse)

CAMK2D Proteins for Sus scrofa (Pig)

CAMK2D Proteins for Xenopus laevis (African clawed frog)

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