Recombinant Mouse Casein kinase I isoform delta (Csnk1d)

1. CK1delta/epsilon disruption mouse had a long (27.4 h) behavioral period to which peripheral clocks entrained in vivo, albeit with an advanced phase ( approximately 6 h). PMID: 29463694
2. Studied roles of CK1delta and CK1e in regulation of PER2 in circadian rhythm. PMID: 29784789
3. the impact of obesity on the circadian system in mice at a behavioural and molecular level was assessed, and determined whether pharmacological targeting of casein kinase 1delta and epsilon (CK1delta/epsilon), key regulators of the circadian clock, can confer metabolic benefit. PMID: 27439882
4. Here, the authors identify another Wnt signaling amplifier, CKIepsilon, which is specifically upregulated in intestinal stem cells and is essential for intestinal stem cell maintenance, especially in the absence of its close isoform CKIdelta. PMID: 28963394
5. Report temperature-compensated CKIdelta-dependent multi-site phosphorylation in mammals underlies temperature compensated phosphorylation in circadian clocks. PMID: 28886336
6. Together, these findings suggest that CK1delta contributes to the efficient repair of DNA damage and the proper functioning of mitotic checkpoints by maintaining appropriate levels of Chk1. PMID: 28125685
7. we conclude that APC/C(Cdh1) controls CK1 delta levels to balance proliferation and cell-cycle exit in the developing CNS PMID: 25843713
8. CK1delta mediates primary ciliogenesis by multiple mechanisms, one involving its centrosomal function and another dependent on its interaction with AKAP450 at the Golgi. PMID: 24648492
9. this article reports the crystallization and structure determination of a new crystal form of casein kinase I delta belonging to space group P21. PMID: 24100552
10. decreases in CKIdelta activity can contribute to the pathogenesis of migraine. PMID: 23636092
11. REGgamma-deficient mice develop premature aging phenotypes that are associated with abnormal accumulation of casein kinase (CK)1delta and p53. Antibody array analysis identified CK1delta as a direct target of REGgamma. PMID: 23766372
12. inactivating mutations in CK1delta impair SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo PMID: 22235331
13. CK1delta plays a more prominent role than CK1epsilon in the maintenance of 24-hour rhythms in the master circadian oscillator PMID: 20421981
14. These results provide strong evidence that the centrosomal localization of CK1delta is required for Wnt-3a-dependent neuritogenesis. PMID: 21422228
15. The results suggest that CK1delta/epsilon binds to and phosphorylates the N-terminal domain of Dnmt1 and regulates Dnmt1 function by reducing the DNA-binding activity. PMID: 20192920
16. physical interaction between PER and CKIdelta/epsilon required for circadian rhythm PMID: 19948962
17. Results indicate that CKIdelta plays several roles in lymphocyte physiology. PMID: 12924632
18. snapin is a new substrate of CK1delta PMID: 17101137
19. The balance between beta-arr and CK1/2 determines whether WNT/RAC-1 or other non-canonical WNT pathways are activated. PMID: 18953287
20. generated mice with liver-specific disruption of CK1delta. In livers from these mice, daytime levels of nuclear PER proteins, and PER-CRY-CLOCK complexes were elevated. In vitro, the half-life of PER2 was increased by approximately 20%. PMID: 19414593
21. The degradation rate of PER2, which is regulated by CKIepsilon/delta-dependent phosphorylation, was temperature-insensitive in living clock cells. PMID: 19805222

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KEGG: mmu:104318

STRING: 10090.ENSMUSP00000018274

UniGene: Mm.216227