Recombinant Mouse Caspase recruitment domain-containing protein 11 (Card11), partial

1. IKKbeta is involved in membrane fusion, and serves as a critical protein kinase required for initial formation and the regulation of the CARMA1/MALT1/Bcl10/CBM complex in platelets. PMID: 29649481
2. LRRK1 physically interacted and potently synergized with CARMA1 to enhance NF-kappaB activation. PMID: 27166870
3. synergistic activity of Card11 mutant and Bcl6 in the development of diffuse large B-cell lymphoma in a mouse model PMID: 27560392
4. CARMA1 clustering through SH3-GUK domain interactions is required for its activation of NF-kappaB signalling PMID: 25602919
5. data suggest that Carma1 and MALT1 play previously unappreciated roles in the activation of mTOR signaling in T cells after engagement of the TCR. PMID: 24917592
6. CARMA1 CARD shows the first homo-dimeric structure of CARD formed by a disulfide bond and reveals a possible biologically important homo-dimerization mechanism PMID: 24224005
7. Data indicate that caspase recruitment domain-containing protein 11 (CARD11) is involved in the pathogenesis of collagen-induced arthritis (CIA) by formation of the CARD11/Bcl10 complex and enhancement of the Th17 cell response. PMID: 24443940
8. Genetic approach demonstrates a critical role for the CARD function of CARMA1 in Treg cell development in vivo. PMID: 24383645
9. both CARMA1 CARD and BCL10 CARD easily self-oligomerized under physiological conditions. PMID: 23525237
10. Findings show that regulation of CARD11 signaling is a critical switch governing the decision between death and proliferation in antigen-stimulated mature B cells. PMID: 23027925
11. TCR/CARMA1/NF-kappaB controls completion of Th17 differentiation. PMID: 23091043
12. These studies provide molecular insight into the assembly of CARMA1 and BCL10. PMID: 22880103
13. Upregulation of CARMA1 in vivo results in Th2 cell-mediated inflammation. Mice expressing constitutively active CARMA1 have elevated IL-4, IL-5, and IL-10 and spontaneously develop pulmonary inflammation and eosinophilia. PMID: 22371397
14. We show that CRADD interacts with BCL10 through its caspase recruitment domain and suppresses interactions between BCL10 and CARMA1 PMID: 22323537
15. Adoptive transfer of T helper cell (Th)2-polarized OX40+CARMA1-deficient antigen-specific CD4+ T cells into wild-type mice induces less airway inflammation in response to antigen challenge than does the transfer of wild-type Th2 cells. PMID: 22075698
16. Decreased T-cell receptor signaling through CARD11 differentially compromises Foxp3 regulatory T-cell suppression that result in selective Th2 dysregulation and allergic disease. PMID: 21320717
17. CARMA1 regulates IL-2 receptor signaling and controls the IL-2-stimulated maturation of Treg precursors to mature Tregs PMID: 20233721
18. the ADAP CARMA1 binding site is required for IKK gamma ubiquitination; both TAK1 and CARMA1 binding sites are required for IkappaB alpha phosphorylation and degradation and NF-kappaB nuclear translocation PMID: 20164171
19. found that antigen receptor-activated CARMA1 underwent lysine 48 (K48) polyubiquitination and proteasome-dependent degradation. PMID: 20008554
20. CARMA1 phosphorylation controls NF-kappaB activation by triggering a shift from an inactive to an active CARMA1 conformer. PMID: 16356855
21. CARMA1 is essential for the development of allergic airway inflammation through its role in T lymphocytes; mice with a deletion in the CARMA1 gene do not develop inflammation in a murine model of asthma. PMID: 16751370
22. CARMA1-deficient B cells are defective in CD40-induced proliferation. PMID: 17048267
23. The active caspase-8c-FLIP complex forms in the absence of Fas (CD95/APO1) and associates with the NF-kappaB signaling molecules RIP1, TRAF2, and TRAF6, as well as upstream NF-kappaB regulators PKC theta, CARMA1, Bcl-10, and MALT1 PMID: 17462996
24. findings provide new insights into ADAP function and the mechanism by which CARMA1 regulates NF-kappaB activation in T cells PMID: 17478723
25. demonstrate a key role for Bcl10 signalosomes in the activation of canonical NF-kappaB signaling as well as JNK and p38 MAPK upon NK-cell triggering. Bcl10 directly cooperates with Malt1 and depends on Carma1 but not on Card9 for NK-cell activation PMID: 18192506
26. NF-kappaB activation signaling through ITAM receptors is regulated by a cell type-specific mechanism depending on the usage of adaptors CARMA1 and CARD9, which determines the PKC dependence of the signaling. PMID: 18606643
27. CARMA1 is essential for Treg development, but is not necessary for the development of other agonist-selected T-cell subsets. Overall, these data reveal an important but differential role for CARMA1-mediated TCR signaling in T-cell development. PMID: 19130560
28. Here we show that mice with a Carma1 point mutation lack thymic CD4(+)Foxp3(+) T(reg) cells and demonstrate a cell-intrinsic requirement for CARMA1 in thymic Foxp3 induction. PMID: 19260764
29. TCR- CARMA1/Bcl10/Malt1 -dependent signals are essential to commit immature thymocytes to the nTreg lineage. PMID: 19454668
30. Cbl-b binds and promotes monoubiquitination to CARMA1, a critical signaling molecule in NFkappaB activation. PMID: 19815501

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KEGG: mmu:108723

STRING: 10090.ENSMUSP00000082941

UniGene: Mm.46187