Recombinant Mouse Cathepsin Z (Ctsz)

Code CSB-YP006206MO
MSDS
Size Pls inquire
Source Yeast
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP006206MO
MSDS
Size Pls inquire
Source E.coli
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP006206MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-BP006206MO
MSDS
Size Pls inquire
Source Baculovirus
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-MP006206MO
MSDS
Size Pls inquire
Source Mammalian cell
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Purity
>85% (SDS-PAGE)
Target Names
Ctsz
Uniprot No.
Alternative Names
CtszCathepsin Z; EC 3.4.18.1
Species
Mus musculus (Mouse)
Expression Region
64-306
Target Protein Sequence
LPKNWDW RNVNGVNYAS VTRNQHIPQY CGSCWAHGST SAMADRINIK RKGAWPSILL SVQNVIDCGN AGSCEGGNDL PVWEYAHKHG IPDETCNNYQ AKDQDCDKFN QCGTCTEFKE CHTIQNYTLW RVGDYGSLSG REKMMAEIYA NGPISCGIMA TEMMSNYTGG IYAEHQDQAV INHIISVAGW GVSNDGIEYW IVRNSWGEPW GEKGWMRIVT STYKGGTGDS YNLAIESACT FGDPIV
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity. Capable of producing kinin potentiating peptides.
Gene References into Functions
  1. The data support a novel role for cathepsin Z in the propagation of IL-1beta-driven neuroinflammation. PMID: 28486971
  2. nigericin-induced cell death depended partly on a single cathepsin, cathepsin X. PMID: 28087651
  3. tumor proliferation was exclusively regulated by cancer cell-intrinsic functions of CtsZ, whereas tumor invasion required contributions from both macrophages and cancer cell PMID: 25274726
  4. Our data show an active role for Ctsz in chronic inflammation and the development of gastric metaplasia. PMID: 23936173
  5. Plaque-associated microglial cells express gamma-enolase and cathepsin X. PMID: 23621429
  6. Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes. PMID: 22451661
  7. cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma PMID: 21966391
  8. analysis of cathepsin X-deficient gastric epithelial cells in co-culture with macrophages during Helicobacter pylori infection PMID: 20736174
  9. Data show that combined loss of Ctsb and Ctsz led to additive effects, resulting in significant and prominent delay of early and advanced tumor development, improved histopathologic tumor grading and 70% reduction in the number of lung metastases. PMID: 20133781
  10. regulation of the phagosomal CatZ, CatB, CatL and CatS contents during dendritic cell activation PMID: 12186844

Show More

Hide All

Subcellular Location
Lysosome.
Protein Families
Peptidase C1 family
Tissue Specificity
Ubiquitous.
Database Links
icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1