Recombinant Mouse Chromogranin-A (Chga)

1. Data suggest that hybrid insulin peptides (HIPs), formed in insulin-secreting-cells by fusion of insulin C-peptide fragments to peptide fragments of chromogranin A or islet amyloid polypeptide, and reactivity of CD4+-T-lymphocytes to HIPs may act as biomarkers of autoimmunity in type 1 diabetes. PMID: 29976617
2. Systemic CST knockout (CST-KO) mice on normal chow diet (NCD) ate more food, gained weight, and displayed elevated blood glucose and insulin levels. PMID: 29432123
3. CgA is an important regulator for coordination of mitochondrial dynamics, secretory vesicular quanta and glucose-stimulated insulin secretion for optimal secretory functioning of beta-cells, suggesting a strong, CgA-dependent positive link between mitochondrial fusion and glucose-stimulated insulin secretion PMID: 28220294
4. Increased myocardial CgA glycosylation and impaired CgA processing to catestatin in heart failure be considered detrimental because CST reduces diastolic Ca2+ leak via direct CaMKIIdelta inhibition. PMID: 28209766
5. performance of CgA-deficient Chga-KO mice in treadmill exercise was impaired. CgA deficiency renders the muscle energy deficient, impairs performance in treadmill exercise and prevents regeneration after exercise-induced tissue damage. PMID: 27799464
6. dilated mitochondrial cristae, endoplasmic reticulum and Golgi complex, as well as increased synaptic mitochondria, synaptic vesicles and glycogen granules in Chga-knockout mice compared to WT mice. PMID: 26572539
7. the presence of ChgA and subsequent activation of ChgA-reactive T cells are essential for the initiation and development of autoimmune diabetes in NOD mice. PMID: 26608914
8. Studied leptin and CST modulation of SGLT1 expression in hyperleptinemic type 2 diabetic mice. PMID: 26552046
9. N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes. PMID: 26453556
10. Data indicate that T-cell receptors that react to chromogranin A (ChgA) and islet amyloid polypeptide precursor (IAPP) autoantigens were impaired when the thymic stromal cells lacked thymus-specific serine protease (TSSP). PMID: 26209627
11. the important roles of CgA and CgB in glucose and cardiovascular homeostasis. This study also unveils the existence of direct implications of Cgs in the control of behaviour and mood. PMID: 25257107
12. Chromogranin A (10-19) and chromogranin A (43-52) were identified as antigens for autoreactive CD8(+) T cells in NOD.beta2m(null).HHD mice. PMID: 25958206
13. Report QT/heart rate variability in a genomically "humanized" chromogranin a monogenic mouse model with hyperadrenergic hypertension. PMID: 24821335
14. We probed the role of the chromogranin A-derived peptide pancreastatin (PST: CHGA(273-301)) by investigating the effect of diet-induced obesity (DIO) on insulin sensitivity of these mice. PMID: 25048197
15. Findings indicate that peptides from the N-terminal region of chromogranin A (ChgA) are able to induce cellular and humoral immune responses in NOD mice. PMID: 24443235
16. It is a neuroinflammatory factor,which activates interleukin-1beta in brain microglia. PMID: 23831373
17. Chromogranin A contributes to a highly efficient system that directly mediates monoamine accumulation and exocytosis in large dense core secretory vesicles. PMID: 22415354
18. Although chromogranins regulate the amine concentration in chromaffin cell secretory vesicles, they are not completely essential. PMID: 21990378
19. serpinin, a novel chromogranin A-derived peptide, is secreted upon stimulation of corticotrophs and plays an important autocrine role in up-regulating protease nexin-1-dependent granule biogenesis PMID: 21436258
20. study concludes that cardiac secretory granules contain Chga, Chgb and Scg2 and that Chga is processed to catestatin in murine heart PMID: 21052719
21. Study propose that CGA may function in the CNS as a prohormone and granulogenic factor in some terminal fields, but also possesses as-yet unknown unique cellular functions within neuronal somata and dendrites. PMID: 20005907
22. Mice displayed a direct Chga gene dose-dependent (copies/genome) activation of Chga expression in both plasma and adrenal glands. PMID: 20139771
23. The exaggerated action of Ucn 2 to reduce BP in the Chga-/- mouse is mediated through inhibition of both catecholamine synthesis and secretion. PMID: 20668031
24. These data suggest that RAGE signaling is capable of driving neuronal differentiation involving CREB activation and induction of chromogranin expression. PMID: 12167613
25. Chromogranin A has a role in secretory granule biogenesis, but is less effective than chromogranin B PMID: 12902350
26. Rescue of elevated BP to normalcy was achieved by humanization of Chga mice. PMID: 16007257
27. essential role of CgA in regulating chromaffin dense core secretory granules biogenesis and catecholamine storage PMID: 16049171
28. Increased expression of the other granin family members is likely to compensate for the Chga deficiency in Chga-null mice. PMID: 16556729
29. Ablation of the Chga gene affected the islet volume, the composition, distribution and nuclear size of islet cell types and plasma insulin concentration. PMID: 18722481
30. Full-length CgA as well as deletion constructs containing the N-terminal 77 residues generated granule-like structures in the cell periphery that co-localized with co-expressed SgII (secretogranin II) PMID: 18973469
31. CHGA acts through the glomerular endothelium to regulate renal function. PMID: 19520754
32. pancreastatin has a role in glucose homeostasis and demonstrates a novel pathway of insulin sensitivity in chromogranin A null mice PMID: 19706599
33. Ablation of Chga expression results in global disturbances in autonomic function, both sympathetic and parasympathetic. PMID: 19819970

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KEGG: mmu:12652

STRING: 10090.ENSMUSP00000021610

UniGene: Mm.4137