Recombinant Mouse Coagulation factor XIII A chain (F13a1)

1. Factor XIII-A and TG2 regulate resorption, adipogenesis and plasma fibronectin homeostasis in bone and bone marrow. PMID: 28387755
2. Suggest that resident macrophages maintain plasma FXIII-A and exclude the platelet lineage as a major contributor. PMID: 28596376
3. These findings provide insight into assembly of the fibrinogen/FXIII-A2B2 complex in both physiologic and therapeutic situations. PMID: 27561317
4. Mast cells have the ability to produce and degrade FXIIIA depending on their chymase expression profile: mast cells expressing chymase degrade FXIIIA, whereas mast cells that do not express chymase mainly produce FXIIIA PMID: 27302551
5. A lack of factor XIII leads to prolonged clotting times, increased signs of inflammation, and elevated bacterial dissemination in streptococcal skin diseases. PMID: 27338836
6. FXIII is a significant determinant of mucosal healing and clinical outcome following inflammatory colitis induced mucosal injury PMID: 26098308
7. These findings expose a newly recognized, essential role for fibrin crosslinking during whole blood clot formation and consolidation and establish FXIIIa activity as a key determinant of thrombus composition and size. PMID: 26324704
8. related to islet dysfunction during the development of type 2 diabetes PMID: 26018251
9. 5-HT inhibits Factor XIII-A-mediated plasma fibronectin matrix assembly and crosslinking in osteoblast cultures via direct competition with transamidation PMID: 25460579
10. High Transglutaminase factor XIII promotes arthritis through mechanisms linked to inflammation and bone erosion. PMID: 25336631
11. Fibrinogen from mice harboring the Fibgamma390-396A mutation exhibited reduced binding to FXIII, and plasma from these mice exhibited delayed FXIII activation and fibrin crosslinking, indicating these residues mediate FXIII binding and activation. PMID: 24983320
12. FXIII-A serves as a preadipocyte-bound proliferation/differentiation switch that mediates effects of hepatocyte-produced circulating pFN. PMID: 24934257
13. Physiological significance of mouse TG2 and Factor XIII through identification of substrate proteins in MC3T3-E1 cells. PMID: 22045386
14. Studies indicate that in FXIII-A-knockout mice, tail-tip bleeding times are doubled and clot stability, assessed by thromboelastography, was impaired compared with wild-type mice. PMID: 23075332
15. FXIIIA mRNA was regulated by the MAP kinase pathway. PMID: 21959563
16. Data indicate that FXIIIa-targeted probe signals showed good overlap with immune-fluorescent fibrin staining images. PMID: 22272319
17. factor XIIIA transglutaminase activity regulates osteoblast matrix secretion and deposition by affecting microtubule dynamics PMID: 21283799
18. Inhibition of TG2 and FXIIIA during early development of lesions reduced the macrophage content in the media of atherosclerotic vessels, while not affecting lesion size or geometric remodeling PMID: 20810110
19. Knockout mouse studies suggest that plasma FXIII-A does not derive primarily (if at all) from circulating platelets and indeed may not derive from the megakaryocyte lineage. PMID: 20086247
20. All FXIII2/2 and FXIII2/+ mice died within 5 days after MI from left ventricular (LV) rupture and had locally reduced levels of FXIII. PMID: 17183677
21. Factor XIII A subunit deficieny is associated with impaired clot retraction PMID: 19996413
22. impaired clot stabilization in FXIII-A mutant mice PMID: 12529747
23. Maternal FXIII plays a critical role in uterine hemostasis and maintenance of the placenta during gestation. PMID: 12933578
24. platelet FXIII and calpain have roles in regulating integrin alpha(IIb)beta3 adhesive function PMID: 15131115
25. FXIII has an essential role in wound repair and remodeling PMID: 16113836
26. analysis of the expression, localization and activity of TG2 and FXIIIA in mineralizing tissues [review] PMID: 16368540
27. Results demonstrate that MC3T3-E1/C14 osteoblasts express two transglutaminase isoforms--TG2 and FXIIIA. PMID: 16469487
28. the entire FXIIIA gene is expressed, thus indicating that the 37-kDa FXIIIA is not a splice variant but a product of posttranslational proteolytic processing. PMID: 17341477
29. Carditis and fibrosis in FXIII-deficient mice might be caused by a faulty or delayed reparative process that was initiated by abnormal haemorrhagic events within heart tissue. PMID: 18278192
30. FXIIIa supports the early survival of micrometastases by a mechanism linked to NK cell function PMID: 18315549

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KEGG: mmu:74145

STRING: 10090.ENSMUSP00000048667

UniGene: Mm.235105