Recombinant Mouse Collagen alpha-1(XI) chain(Col11a1) ,partial

Code CSB-YP736811MO
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Source Yeast
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Code CSB-EP736811MO
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Source E.coli
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Code CSB-EP736811MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP736811MO
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Source Baculovirus
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Code CSB-MP736811MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Col11a1
Uniprot No. Q61245
Alternative Names Col11a1Collagen alpha-1(XI) chain
Species Mus musculus (Mouse)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.
Gene References into Functions
  1. Taken together, these results indicate that the transcription factor Sp1 upregulates the proximal promoter activity of the mouse Col11a1 gene in chondrocytes. PMID: 26487428
  2. these results indicate that the transcription factor NF-Y regulates the proximal promoter activity of mouse Col11a1 gene in chondrocytes PMID: 24092017
  3. Stickler syndrome and Marshall syndrome mutations in COL11A1 cause hearing loss via dominant negative effects upon wild-type fibrillar collagen polypeptides in the extracellular matrices of the cochlea. PMID: 12527136
  4. the cho mutation leads to osteoarthritis through a mechanism that does not initially involve mechanical factors. PMID: 13130470
  5. The expression patterns suggest essential roles for Col11a1 and Col11a2 in the basilar or tectorial membranes. PMID: 15141750
  6. Lef1 is an activator of the Col11a1 promoter and that Col11a1 suppresses terminal osteoblast differentiation PMID: 18280717

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Involvement in disease Defects in Col11a1 are associated with chondrodysplasia, an autosomal recessive disease characterized by skeletal defects caused by abnormalities in the cartilage of limbs, ribs, mandibles and trachea.
Subcellular Location Secreted, extracellular space, extracellular matrix.
Protein Families Fibrillar collagen family
Database Links

KEGG: mmu:12814

STRING: 10090.ENSMUSP00000089793

UniGene: Mm.209715

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