Recombinant Mouse Corticotropin-releasing factor-binding protein(Crhbp)

Code CSB-YP723321MO
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Source Yeast
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Code CSB-EP723321MO
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Source E.coli
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Code CSB-EP723321MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP723321MO
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Source Baculovirus
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Code CSB-MP723321MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Crhbp
Uniprot No. Q60571
Alternative Names CrhbpCorticotropin-releasing factor-binding protein; CRF-BP; CRF-binding protein; Corticotropin-releasing hormone-binding protein; CRH-BP
Species Mus musculus (Mouse)
Expression Region 25-322
Target Protein Sequence YLEVQE AAVYDPLLLF SANLKRDLAE EQPYRRALRC LDMLSLPGQF TFTADRPQLH CAAFFIGEPE EFITIHYDLV SIDCQGGDFL KVFDGWILKG EKFPSSQDHP LPTMKRYTDF CESGLTRRSI RSSQNVAMVF FRVHEPGNGF TITIKTDPNL FPCNVISQTP SGRFTLVVPY QHQNCSFSII YPVAIKISDL TLGHLHGLQL KKPAAGCGGT GDFVELLGGT GLDPSKMMPL ADLCYPFLGP AQMKISCDNA VVRMVSSGKH INRVTFEYRQ LEPFELETST GNSIPEYCLS SL
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
Gene References into Functions
  1. Repeated cycles of binge drinking alter CRF-BP mRNA expression in the medial prefrontal cortex. PMID: 27374820
  2. Ventral tegmental area CRH-BP is involved in the initial stages of escalated ethanol drinking. PMID: 26247973
  3. These studies demonstrate a role for the pituitary CRH-BP in attenuating the HPA response to stress in female mice. PMID: 25731977
  4. estrogen-regulated expression of corticotropin-releasing hormone-binding protein in lactotropes in female mice suggests that the pituitary is an important site for interactions between the hypothalamic-pituitary-adrenal axis and other endocrine systems PMID: 12446601
  5. Evidence is presented suggesting that the CRH-BP may be required for corticotropin-releasing factor-induced potentiation of NMDA receptors in dopaminergic neurons of the ventral tegmental area. PMID: 12895416
  6. GnRH induces a 3.7-fold increase in CRH-BP mRNA levels via multiple intracellular signaling pathways and a multipartite GnRH response element. PMID: 15976007
  7. analysis of regulation and function of CRH-BP [review] PMID: 16368564
  8. Deletion of corticotropin-releasing factor binding protein selectively impairs maternal, but not intermale aggression. PMID: 18929624

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Subcellular Location Secreted
Protein Families CRF-binding protein family
Database Links

KEGG: mmu:12919

STRING: 10090.ENSMUSP00000042578

UniGene: Mm.316614

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