Recombinant Mouse Cytochrome P450 19A1 (Cyp19a1)

1. This study demonstrated that Aromatase expression in spinal cord and medulla in sex difference. PMID: 28649695
2. These studies suggest an association between adiposity, aromatase estrogenic capacity and atrial arrhythmogenicity. PMID: 28822806
3. Increased adipose tissue aromatase activity reduces adipose tissue inflammation and improves insulin sensitivity in male mice. PMID: 28655716
4. Aromatase-knockout (ArKO) mice cannot synthesize estrogens in vivo. Male ArKO mice developed hepatic steatosis accompanied by high testosterone levels. PMID: 28341248
5. results show that the Aha1-Hsp90-PKM2/HIF-1alpha axis mediates the induction of aromatase in Li-Fraumeni Syndrome. PMID: 27467582
6. aromatase could modulate pituitary LH-positive cells in males through local estradiol synthesis. PMID: 27160809
7. Findings indicate that sex chromosome factors determine sex differences in aromatase expression in the stria terminalis and in the anterior amygdaloid area of mouse embryos. PMID: 26231585
8. Aromatase plays an important role in the survival of metastatic ERalpha breast cancer cells by suppressing anoikis. PMID: 25837259
9. aromatase may play a key role in the pathogenesis of Sjogren syndrome-like lesions by controlling the target organ and adipose tissue-associated macrophage; increased MPC1 protein expression has a role in adiposity PMID: 25447050
10. The protective effect of female gender on abdominal aortic aneurysms is due to estrogen synthesis and requires the presence of both ovarian and extragonadal/peripheral aromatase. PMID: 24582702
11. Male Aromatase knockout mice develop hepatic glucose intolerance. PMID: 24520329
12. Cerebrovascular endothelial aromatase plays an important and sexually dimorphic role in cerebrovascular function and that aromatase inhibitors in clinical use may have cardiovascular consequences in both males and females. PMID: 24508640
13. CYP19A1 gene is driven by promoters PII, I.4, and I.3 in the seminal vesicles, and by promoters PII and I.4 in the urinary bladder. PMID: 23239821
14. Lhx2 is involved in the transcriptional regulation of aromatase in the rodent brain. PMID: 22734700
15. Glucocorticoids alter aromatase expression in the hypothalamus and might regulate gonadotropin pulses and the menstrual cycle. PMID: 22705581
16. Aromatase-deficient mice displayed increased cortical neuronal density and occasional cortical heterotopias PMID: 22426781
17. Data show that the human aromatase gene can be expressed via its native promoters in a wide variety of mouse tissues and in a distribution pattern nearly identical to that of humans. PMID: 22508516
18. expression level of estrogen receptors and aromatase in testis during aging PMID: 22366072
19. investigation of role of aromatase in disease and inflammatory processes: Characterization of aromatase and apolipoprotein E double knockout mice as model of metabolic syndrome X. PMID: 22185842
20. Impact of ovarian sex steroids on ovulation and ovulatory gene induction in aromatase-null mice. PMID: 22147013
21. in the acute ischemia/reperfusion setting, more robust functional recovery, reduced cellular injury, and modified cardiomyocyte Ca(2+) handling was observe in aromatase-deficient hearts PMID: 22028441
22. An organizational effect of estradiol during a critical period of development on the expression of biological rhythms. PMID: 21816154
23. Mechanisms involved in amphetamine-induced c-fos expression are altered in aromatase knockout mice. PMID: 21093158
24. Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland PMID: 21372033
25. The sexual differentiation of kisspeptin neuronal number was lost in aromatase knockout mice PMID: 19945459
26. The study provides the first in vivo evidence linking the LH receptor, the EGFR, and ERK1/2 as sequential components of a pathway that regulates ovarian Cyp19a1 expression. PMID: 20093417
27. Liver mitochondria isolated from ArKO mice displayed increased activity of the mitochondrial respiratory complex IV and were less prone to undergo cyclosporin A-sensitive mitochondrial permeability transition induced by calcium loading. PMID: 20194728
28. FXR is able to compete with steroidogenic factor 1 in binding to a common sequence present in the aromatase promoter region interfering negatively with its activity. PMID: 20026603
29. Data describe the effects of genistein and three synthetic estrogen receptor alpha/beta agonists in aromatase knockout mice by two routes of administration. PMID: 19686804
30. Aromatase-deficient (ArKO) mice accumulate excess adipose tissue. PMID: 11850201
31. Alternations in hepatic expression of fatty-acid metabolizing enzymes in ArKO mice and their reversal by the treatment with 17beta-estradiol or a peroxisome proliferator. PMID: 11850202
32. Aromatase overexpression transgenic mice model: cell type specific expression and use of letrozole to abrogate mammary hyperplasia without affecting normal physiology. PMID: 11850204
33. Bone phenotype of the aromatase deficient mouse. PMID: 11850207
34. The ovarian phenotype of the aromatase knockout (ArKO) mouse. PMID: 11850223
35. Characterization and purification of a protein binding to the cis-acting element for brain-specific exon 1 of the mouse aromatase gene. PMID: 11850232
36. REVIEW: effects of depletion of endogenous estrogens in the aromatase deficient mouse (ArKO) with respect to spermiogenesis, development of obesity, and development of osteoporosis PMID: 12160996
37. Inhibition of p-450 aromatase prevents feminisation and induces protection during cysticercosis PMID: 12350373
38. The mouse Cyp19 gene includes three different promoters that specifically direct expression in ovary, testis, and brain. PMID: 12604651
39. Induction of Fos in the accessory olfactory system by male odors persists in female mice with a null mutation of the aromatase (cyp19) gene. PMID: 12725902
40. Forebrain Fos responses to reproductively related chemosensory cues in aromatase knockout mice. PMID: 12754080
41. In male, but not female, aromatase knockout mice, there was an age-related reduction of prepulse inhibition of acoustic startle. PMID: 12884966
42. aromatase knockout females presented with elevated serum cholesterol; conversely, aromatase knockout males had elevated hepatic cholesterol levels. PMID: 12933663
43. These findings indicate that the biosynthetic enzyme P450 aromatase is key to endogenous neuroprotection in females and suggest that enhancing local, nongonadal estrogen formation could have therapeutic implications in cerebral ischemic neuropathology PMID: 14507969
44. Review confirms the findings of aromatase neuroprotective effect in reactive astrocytes in vitro through use of aromatase knockout mice, which show enhanced hippocampal neurodegeneration in response to neurotoxins. PMID: 14993062
45. aromatase activity is critical for normal autonomic control of the heart and, hence, for reducing the deleterious effects of high BP variability. PMID: 15178650
46. Oestrogen-deficient female aromatase knockout (ArKO) mice exhibit depressive-like symptomatology. PMID: 15245494
47. PGF(2alpha) decreases luteal P450arom mRNA levels at the end of pregnancy in rodents by inhibiting cyp19 expression. PMID: 15271885
48. The aromatase immunostaining was found in cryptorchid-KE Leydig cells. PMID: 15823796
49. Aromatase transgenic mice show increased levels of the estrogen receptor alpha and beta (ERalpha, ERbeta) suggesting that this receptor may play an important role in the initiation of estrogen-mediated mammary hyperplasia observed in these mice. PMID: 15955696
50. p450 aromatase may have a role in male infertility associated with chronic inflammation in the testis PMID: 16306085

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KEGG: mmu:13075

STRING: 10090.ENSMUSP00000034811

UniGene: Mm.478781