Recombinant Mouse Cytosolic phospholipase A2 (Pla2g4a)

1. This study demonstrated that the Potassium channels-mediated electrophysiologic responses are inhibited by cytosolic phospholipase A2alpha ablation. PMID: 29112675
2. Compared to cPLA2alpha(+/+) Tg-AD mice, the amyloid plaque formation was significantly downregulated in the brain of cPLA2alpha(+/-) Tg-AD mice, but not in cPLA2alpha(-/-) Tg-AD mice. PMID: 28648388
3. the cytosolic phospholipase cPLA2alpha is activated through Gbetagamma downstream of Smo to release arachidonic acid. Arachidonic acid binds Smo and synergizes with CRD-binding agonists, promoting Smo ciliary trafficking and high-level signaling. PMID: 28591579
4. In microglia, cPLA2 up-regulates the expression of CD40 protein. PMID: 28187742
5. LacCer alone simultaneously stimulates two processes to activate cPLA2 alpha: a phosphorylation signal and attachment of the enzyme to substrate membranes. PMID: 28444900
6. these studies suggests that cPLA2alpha expressed by neutrophils, but not epithelial cells, plays a significant role in infection-induced neutrophil transepithelial migration by mediating LTB4 synthesis during migration, which serves to amplify the magnitude of neutrophil recruitment in response to epithelial infection PMID: 28887431
7. this study shows that cPLA2alpha contributes to immune surveillance and host defense in the lung to prevent infection by the commensal fungus Candida albicans and to dampen inflammation PMID: 27501951
8. Reduction of cPLA2alpha in the brainstem and spinal cord significantly attenuated the development of an animal model of amyotrophic lateral sclerosis. PMID: 27250836
9. Data suggest that the ability of pyrrophenone to block endoplasmic reticulum (ER) calcium release is an off-target effect since it occurs in fibroblasts lacking cytosolic phospholipase A2alpha (cPLA2alpha). PMID: 27620490
10. these results show that preadipocyte cPLA2alpha activation is a hitherto unrecognized factor for adipogenesis in vitro and in vivo. PMID: 27317983
11. show that accumulation of Abeta induced elevation of APP protein expression mediated by cPLA2 alpha, PGE2 release, and CREB activation via protein kinase A pathway PMID: 25533654
12. Prostaglandins from cPLA2-alpha/COX1 pathway and mitogen-activated protein kinases regulate gene expression in Candida albicans-infected macrophages. PMID: 26841868
13. critical role in development of mouse model of colitis PMID: 26548451
14. The goal for this study is to elucidate the role of cPLA2IV in mediating the oxidative and inflammatory responses in microglial cells PMID: 26520095
15. Thymocyte maturation can occur independently of cPLA2-alpha. PMID: 25969996
16. The study reports the formation of a multiprotein complex at the G2-to-M transition in vitro and in vivo. Group IVA cytosolic phospholipase A2 (cPLA2-alpha) acts as a bridge in this complex to promote binding of SIRT2 to cyclin A-Cdk2. PMID: 26303530
17. osteoblastic cytosolic phospholipase A2 is crucially involved in ET-1-induced prostaglandin formation. PMID: 25504011
18. our data indicate that SR-A localizes in LRs and that LRs are required to couple SR-A to PLA2 activation during SRA-mediated macrophage attachment. PMID: 25070949
19. cPLA2 participates in CRHR1-induced apoptosis and CRHR2-inhibited apoptosis. PMID: 24776847
20. cPLA2 deletion ameliorates motor deficits and reduces cell loss and tissue damage after spinal cord injury. PMID: 24623140
21. Contrary to cPLA2alpha, iPLA2beta spares arachidonate-containing phospholipids. PMID: 24337743
22. LMW HA was a potent stimulant of AA release in a time- and dose-dependent manner, induced cPLA2alpha, ERK1/2, p38, and JNK phosphorylation, as well as activated COX2 expression and prostaglandin (PG) E2 production PMID: 24366870
23. C. albicans stimulates an autocrine loop in macrophages involving cPLA2alpha, cyclooxygenase 1-derived prostaglandins and increased cAMP that globally effects expression of genes involved in host defense and inflammation. PMID: 23950842
24. Data from transgenic/knockout mice suggest that Pla2g4a plays role in regulation of autophagy in islet beta-cells; thus, induction of Pla2g4a under endoplasmic reticulum stress (as in diabetes) is key component in beta-cell apoptosis. PMID: 23411472
25. LacCer is a direct activator of cPLA2alpha. PMID: 23801329
26. The results of this study further suggested that cPLA2alpha and its cleaved arachidonic acids play important roles in cortical neuronal maturation and in normal neurochemical processes. PMID: 23266724
27. cPLA(2)alpha/arachidonic acid/2-AG signaling pathway mediates DSE at parallel fiber-Purkinje cell synapse PMID: 22927908
28. cPLA2 plays a key role in amyloid-beta oligomer-associated neurodegeneration and as such represents a potential therapeutic target for the treatment of Alzheimer's disease. PMID: 22188721
29. data strongly suggest that PLA(2)G4A amplifies hCG induction of PTGS2 and colocalizes with the induced PTGS2, thus contributing to robust PG production required for optimal ovulation and fertilization in rodents PMID: 22673578
30. IVA-PLA2 deficiency attenuates not only lipid deposition in the liver but also hepatic fibrosis formation. PMID: 22750514
31. Cleavage of annexin A1 activates cytosolic PLA2 by phosphorylation, stimulating a proinflammatory reaction in activated mast cells. PMID: 22539796
32. Disruption of group IVA cytosolic phospholipase A(2) attenuates myocardial ischemia-reperfusion injury partly through inhibition of TNF-alpha-mediated pathway. PMID: 22427514
33. a new mechanism of action for PLA(2)IValpha, which demonstrates that the membrane binding, and not the enzymatic activity, is required for PLA(2)IValpha modulation of FcR-mediated phagocytosis. PMID: 22393044
34. Arachidonic acid can induce cPLA(2alpha)/COX-2 pathway activation in mouse endometrial stromal cells. PMID: 22369775
35. Hepatocyte cPLA(2)alpha protects against Fas-induced liver injury and this effect is mediated at least in part through the upregulation of EGFR. PMID: 21703211
36. cPLA2 and its metabolite lipid mediators induce autophagy in a murine macrophage cell line and in human primary monocytes. PMID: 22003202
37. These studies are the first to identify a protective role for cPLA(2) in ischemia/reperfusion injury in any organ and raise concerns over long-term inhibition of cPLA(2). PMID: 21884509
38. Analysis of two major intracellular phospholipases A(2) (PLA(2)) in mast cells reveals crucial contribution of cytosolic PLA(2)alpha, not Ca(2+)-independent PLA(2)beta, to lipid mobilization in proximal mast cells and distal fibroblasts. PMID: 21880721
39. PLA2G4A is expressed primarily in the interstitial cells of wild-type mouse testes throughout maturation. PMID: 21762109
40. in a relapsing-remitting model of EAE in SJL mice, therapeutic administration of a cPLA(2)alpha inhibitor, starting from the peak of disease or during remission, completely protected the mice from subsequent relapses. PMID: 21746963
41. In L929 cells, expression of hCERK with and without ceramide caused cell rounding and lactate dehydrogenase leakage, respectively, and the responses were significantly less in a stable clone of L929 cells lacking cPLA2alpha. PMID: 21621503
42. Endothelial cPLA2alpha may play a principal role in L-NAME-induced hypertension and may be a target molecule for maintaining endothelial function under NO inhibition. PMID: 21350197
43. results show that the common K651R polymorphism confers slightly higher activity to the enzyme, suggesting a role of this residue in favoring a catalytically active conformation of cPLA(2)alpha. PMID: 21247147
44. Cytosolic PLA2alpha is involved in vivo with ICAM-1 upregulation in mouse models of inflammation; PLA2alpha has a specific role in signaling events leading to induction of ICAM-1 protein expression in endothelial cells. PMID: 21199900
45. Studies help determine the regulation and function of the cPLA(2) family members. PMID: 20705608
46. In mouse models of brain and lung cancer, cPLA(2) and lysophospholipids have key regulatory roles in tumor angiogenesis. cPLA(2) inhibition may be a novel effective antiangiogenic therapy. PMID: 20729478
47. Data demonstrate that over-expression of caveolin-1 aggravates the AT-1 injury induced by LPS, involving in modulation of the cPLA2 mediated by the cPLA2/p38 MAPK pathway. PMID: 20099006
48. These results indicate that cPLA2alpha modulates the earliest molecular and injury responses after cerebral ischemia, including COX2 expression, and have implications for the potential clinical use of cPLA2alpha inhibitors. PMID: 20673332
49. CFTR knockout mice develop enhanced airway constriction through a cPLA2alpha-dependent mechanism. PMID: 20429932
50. Data show that inhibition of cPLA(2)alpha activity with specific inhibitors blocked growth factor-induced membrane and actin dynamics, suggesting an important role for cPLA(2)alpha in these processes. PMID: 20112044

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KEGG: mmu:18783

STRING: 10090.ENSMUSP00000070868

UniGene: Mm.4186