Recombinant Mouse DNA (cytosine-5)-methyltransferase 3A (Dnmt3a), partial

1. Dnmt3a appears to regulate satellite cell differentiation via DNA methylation. This mechanism may play a role in the decreased regeneration capacity during atrophy such as in aged sarcopenia. PMID: 29146735
2. DNMT3A and TET1 regulate the epigenome and gene expression at specific targets via their functional interplay. PMID: 30001199
3. individual pain vulnerability may be inherent mostly in the emotional/affective component of chronic pain and remain consistent in different aspects of negative emotion, in which adaptive changes in the function of DNA methyltransferase 3a for DNA methylation in central amygdala may play an important role. PMID: 28849714
4. Taken together, these data demonstrate that adipose Dnmt3a is a novel epigenetic mediator of insulin resistance in vitro and in vivo. PMID: 29091029
5. our Dnmt3a R878H mice have shown that leukemic cells have altered gene expression and epigenetic regulatory patterns contributing to the growth/survival advantage over WT mice.The present study found that the DNMT3A mutation contributed to hypomethylation in the gene body region of mTOR in Dnmt3aR878H/WT mice. PMID: 28461508
6. Data demonstrate that DNMT3A and DNA methylation are key modulators of mast cell responsiveness to acute and chronic stimulation. PMID: 28167789
7. These data suggest that DNMT3a is required for nerve injury-induced and MBD1-mediated epigenetic silencing of the MOR and KOR in the injured DRG. DNMT3a inhibition may serve as a promising adjuvant therapy for opioid use in neuropathic pain management. PMID: 28267064
8. Data show that conditional deletion of Dnmt3a and simultaneous "knock in" of Flt3ITD/+, cooperate to drive leukemia development at a faster rate than Dnmt3a loss alone. PMID: 27636998
9. Deletion of DNMT3a in postnatal forebrain neurons does no alter affective behavior. PMID: 27545441
10. Altogether, the authors demonstrate that Dnmt3a and Dnmt3b protect the epidermis from tumorigenesis and that squamous carcinomas are sensitive to inhibition of PPAR-gamma. PMID: 28425913
11. This is attributed in part to ineffective repression of Tcf1 expression in knockout T cells, as DNMT3a localizes to the Tcf7 promoter and catalyzes its de novo methylation in early effector WT CD8(+) T cells. These data identify DNMT3a as a crucial regulator of CD8(+) early effector cell differentiation and effector versus memory fate decisions. PMID: 27582468
12. Compared the activity of individual DNMT3A isoforms in embryonic stem and neuronal progenitor cells and report that these isoforms differ in their genomic binding and DNA methylation activity at regulatory sites. We identify that the longer isoform DNMT3A1 preferentially localizes to the methylated shores of bivalent CpG island promoters in a tissue-specific manner. PMID: 29074627
13. Study shows that in the mouse brain during early life, the DNA methyltransferase DNMT3A preferentially binds transiently to intergenic regions and across transcribed regions of lowly expressed genes and that this binding primarily determines the pattern of DNA methylation at CA sequences in the adult brain. PMID: 29056337
14. conditional inactivation of Dnmt3a in mouse hematopoietic cells leads to an accumulation of immature progenitors in the thymus, which are less apoptotic. These data demonstrate that Dnmt3a is required for normal T-cell development, and acts as a T-ALL tumor suppressor PMID: 28321121
15. These data demonstrate that haploinsufficiency for Dnmt3a alters hematopoiesis and predisposes mice (and probably humans) to myeloid malignancies by a mechanism that is not yet clear. PMID: 28872462
16. Loss of DNMT3A expression is associated with development of malignancy. PMID: 27428748
17. confirm the transformation potential of DNMT3A(R882H) Tet2(-/-) progenitors and represent the first cooperative model in mice involving Tet2 inactivation driving lymphoid malignancies PMID: 26876596
18. overexpression of Dnmt3a partially rescued the impairment of adipogenesis induced by AP2alpha knockdown. PMID: 27906176
19. These data show that DNMT3a plays an important role in regulating embryonic cardiomyocyte gene expression, morphology and function. PMID: 27306334
20. in addition to the established role of Dnmt3a in regulating self-renewal, Dnmt3a regulates tissue tropism and limits myeloid progenitor expansion in vivo. PMID: 26710888
21. Dnmt3a mutations induced hematopoietic stem cell expansion, cooperated with mutations in the FMS-like tyrosine kinase 3 gene (Flt3(ITD)) and the nucleophosmin gene (Npm1(c)) to induce AML in vivo, and promoted resistance to anthracycline chemotherapy. PMID: 27841873
22. miR-29a/b/c repressed DNMT3A expression by directly targeting its 3' untranslated region (3' UTR). Our data reveal a novel mechanism of miR-29a/b/c in the regulation of adipogenesis PMID: 28114345
23. DOT1L may play a critical role in DNMT3A-mutant leukemia. PMID: 27335278
24. Thyroid regulation of Dnmt3a may be an evolutionarily conserved mechanism for modulating global changes in DNA methylation during postnatal neurological development. PMID: 27387481
25. this study shows that Dnmt3a enhances antiviral responses via a non-canonical mechanism to activate the kinase TBK1 and the production of type I interferons in macrophages PMID: 27240213
26. observations suggested that Sept9 contributed to alleviate liver fibrosis might partially through promoting activated HSCs apoptosis and this anti-fibrogenesis effect might be blocked by DNMT-3a mediated methylation of Sept9 PMID: 27939986
27. DNMT3A haploinsufficiency results in reversible epigenetic alterations that transform FLT3(ITD)-mutant myeloproliferative neoplasm into AML. PMID: 27016502
28. Study provides evidence that Arg882-mutated DNMT3A contributes to acute myeloid leukemia pathogenesis through epigenetic activation of leukemia-related genes. PMID: 27344947
29. Dnmt3a is a haplo-insufficient tumor suppressor in chronic lymphocytic leukemia and highlights the importance of deregulated molecular events in disease pathogenesis. PMID: 27134162
30. Cigarette smoke induces proteosomal-mediated degradation of DNMT3a in embryonic orofacial cells. PMID: 26482727
31. The stress-induced Brg1-G9a/GLP-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals. PMID: 26952936
32. both the PML-RARA-driven competitive transplantation advantage and development of acute promyelocytic leukemia (APL) required DNMT3A PMID: 26595813
33. Overexpression or knockdown of medial prefrontal cortex Dnmt3a levels decreases or increases anxiety-like behavior, respectively. PMID: 26791204
34. DKO cardiomyocytes showed virtual absence of targeted Dnmt3a and Dnmt3b mRNA transcripts. PMID: 26098432
35. An unexpected oncogenic role for Dnmt3a in MTCL through methylation-independent repression of Dnmt3b. PMID: 25639876
36. knock-outs display loss of DNA methylation at transcriptional start site of long non-coding RNAs enriched in hematopoietic stem cells PMID: 25772072
37. These results indicated a role for the miR29b-Dnmt3a/3b-DNA methylation axis in mouse early embryonic development, and we provide evidence that miR29b is indispensable for mouse early embryonic development PMID: 25766529
38. Our results suggest that DNMT3A mutations and oncogenic RAS cooperate to regulate hematopoietic stem and progenitor cells and promote myeloid malignancies. PMID: 25801914
39. data suggest that Dnmt3a and Dnmt3b are critical to regulate the onset of Igkappa light chain rearrangement during early B-cell development PMID: 26059604
40. These correlational data suggest that DNA methylation via Dnmt3a in the hippocampus co-regulates adaptivity of the behavioral response to chronic social defeat stress PMID: 25445743
41. Study reveals that the DNMT3 de novo methyltransferases DNMT3A and DNMT3B play both redundant and specific functions in the establishment of DNA methylation in the mouse embryo. PMID: 25476147
42. necessary for normal memory formation PMID: 24937014
43. A severely altered chromatin structure during retinal degeneration coincided with an increased expression of the DNMT isozyme DNMT3a. PMID: 25476906
44. Hypomethylation of imprinted genes in Dnmt3a-deficient oocytes was directly inherited to the embryos, but repetitive elements were re-methylated during development. PMID: 20132320
45. Administration of THC into WT mice increased promoter methylation of DNMT3a and DNMT3b in THC-induced myeloid-derived suppressor cells, which correlated with reduced expression of DNMT3a and DNMT3b. PMID: 25713087
46. The results show that Dnmt3a is predominantly expressed in the stem/progenitor cell compartment of tumors and that deletion of Dnmt3a inhibits the earliest stages of intestinal tumor development. PMID: 24837369
47. Combined loss of Dnmt3a and Dnmt3b was synergistic, resulting in enhanced hematopietic stem cell self-renewal and a more severe block in differentiation. PMID: 25130491
48. S-adenosylmethionine-mediated DNA methylation by Dnmt3a regulates osteoclastogenesis via epigenetic repression of anti-osteoclastogenic genes. PMID: 25706873
49. DNMT3A (and DNMT1) have a role in DNA methylation which is impaired following ethanol administration, but not in CB1-receptor knockout mice. PMID: 25487288
50. Ectopic introduction of c-Kit variants into a Dnmt3a-deficient background produced acute leukemia with a short latency (median survival, 67 days). PMID: 25416276

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KEGG: mmu:13435

STRING: 10090.ENSMUSP00000020991

UniGene: Mm.470389