DNMT3A

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.

DNMT3A Antibodies

DNMT3A Antibodies for Homo sapiens (Human)

DNMT3A Proteins

DNMT3A Proteins for Mus musculus (Mouse)

DNMT3A Proteins for Rattus norvegicus (Rat)

DNMT3A Proteins for Gallus gallus (Chicken)

DNMT3A Proteins for Homo sapiens (Human)

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