Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 19(Adam19),partial

Code CSB-YP001279MO1
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Source Yeast
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Code CSB-EP001279MO1
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Source E.coli
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Code CSB-EP001279MO1-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP001279MO1
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Source Baculovirus
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Code CSB-MP001279MO1
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Adam19
Uniprot No. O35674
Alternative Names Adam19; MltnbDisintegrin and metalloproteinase domain-containing protein 19; ADAM 19; EC 3.4.24.-; Meltrin-beta
Species Mus musculus (Mouse)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).
Gene References into Functions
  1. TGF-beta stimulation of renal cells results in a significant up-regulation of Adams 10, 17, 12, and 19 PMID: 24103556
  2. Thus, we found that electrical stimulation accelerated NMJ formation, possibly through activation of ADAM19/neuregulin/ErbB signaling in NG108-15 cells. PMID: 23603262
  3. Meltrin beta-mini is a new isoform that induces neuron outgrowth in neuronal cells PMID: 12482604
  4. evaluation of its catalytic activity; potential role in shedding TRANCE in cells where both molecules are highly expressed, such as in osteoblasts PMID: 12682046
  5. participates in the development of the endocardial cushion PMID: 14975714
  6. Meltrin beta expressed in cardiac neural crest cells is required for ventricular septum formation of the heart. PMID: 17126315
  7. This study identifies a novel sheddase, ADAM17, for Kitl1 and Kitl2, and demonstrates that ADAM19 can reduce ADAM17-dependent phorbol-ester-stimulated Kitl1 ectodomain shedding. PMID: 17344430
  8. meltrin-beta functions as a modulator of juxtacrine signaling from axons that activate the Akt pathway and the Krox-20 expression, which is the prerequisite for Schwann cell differentiation PMID: 19049978
  9. It plays multiple roles in the regulation of signal transduction between neuronal cells. (review) PMID: 19827605

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Subcellular Location Membrane, Single-pass type I membrane protein
Tissue Specificity Widely expressed, with the highest expression in bone, heart and lung, followed by brain and spleen and relatively low expression in liver, skeletal muscle, kidney and testis. In bone, primarily expressed in cell of the osteoblast lineage and not detected
Database Links

KEGG: mmu:11492

STRING: 10090.ENSMUSP00000011400

UniGene: Mm.89940

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