Recombinant Mouse Dynamin-2 (Dnm2), partial

1. DNM2 knockdown via two different strategies can efficiently correct the myopathy due to DNM2 mutations. PMID: 30291191
2. analysis of epistasis between Mtm1 and Dnm2 reveal possibilities for DNM2 knockdown as a therapeutic approach for X-linked centronuclear myopathy (XLCNM), or myotubular myopathy PMID: 28589938
3. Excitation-contraction coupling is impaired in the muscle fibres of the Dnm22 (R465W) mutant mice. PMID: 29071728
4. Inhibition of cortactin or dynamin-2 abrogated the increased virus entry observed in DBN1-deficient cells, suggesting that DBN1 suppresses dynamin-mediated endocytosis via interaction with cortactin. PMID: 28416666
5. The authors demonstrate that ablation of DNM2 in early spermatogenesis results in germ cell arrest during prophase I of meiosis, subsequent loss of all post-meiotic germ cells and concomitant sterility. These effects become exacerbated with age, and ultimately result in the demise of the spermatogonial stem cells and a Sertoli cell only phenotype. PMID: 27725702
6. expressed throughout the epididymis, but localized to the Golgi apparatus of the principal cells in the proximal segment and the luminal border of these cells in more distal segments PMID: 28395327
7. Loss of Dynamin 2 GTPase function results in microcytic anaemia. PMID: 28466468
8. DNM2 mutations cooperate with Lmo2 T-cell oncogenes by enhancing IL-7 signalling. PMID: 27118408
9. Genetic disruption of Dyn2 GTPase activity selectively in hepatic stellate cells enhances fibrogenesis. PMID: 27840081
10. Oxidative stress-induced apoptosis and reactive oxygen species production are attenuated by not only Drp1 inhibition but also Dynamin 2 inhibition, implicating Dynamin 2 as a mediator of oxidative stress in cardiomyocytes. PMID: 27802433
11. Results show that centronuclear myopathy associated Dyn2 mutants are gain-of-function mutations, and their primary effect in muscle is T-tubule disorganization, which explains the susceptibility of muscle to Dyn2 hyperactivity. PMID: 26199319
12. Dynamin 2 might participate in the early embryonic development through an actin-based cytokinesis PMID: 25421092
13. Dynamin 2 has a role in endocytosis and in sustaining T-cell receptor signaling and driving metabolic reprogramming in T lymphocytes PMID: 25831514
14. DNM2-dependent endocytosis in megakaryocytes regulates megakaryopoiesis, thrombopoiesis, and bone marrow homeostasis. PMID: 25468568
15. Thus dynamin that was recently found to control late stages of myoblast fusion also controls late stages of macrophage fusion, revealing an intriguing conserved mechanistic motif shared by diverse cell-cell fusion processes. PMID: 25336256
16. FGF21 has a role in promoting endothelial cell angiogenesis through a dynamin-2 and Rab5 dependent pathway PMID: 24848261
17. Dynamin 2 regulates spindle migration and polar body extrusion during mouse oocyte meiosis through an actin-based pathway PMID: 24735075
18. Dynamin 2 deficiency caused impaired egress through regulation of S1PR1 signaling. PMID: 24638168
19. Dnm2 uncouples VEGF signaling from function and coordinates the endocytic turnover of integrins in a manner that is crucially important for angiogenesis in vitro and in vivo. PMID: 24598168
20. MTM1 and DNM2 regulate muscle organization and force through a common pathway. PMID: 24569376
21. study found DNM2 function in skeletal muscle is required for proper development; loss of DNM2 function in skeletal muscles initiates a chain of harmful parallel and serial events, involving dysregulation of lipid drolets and mitochondrial defects within altered muscle fibers, defective NMJs and peripheral nerve degeneration PMID: 23813975
22. These findings provide new evidence for the participation of the autolysosome in hepatocyte lipid droplet metabolism and demonstrate a novel role for dynamin2 in the function and maturation of an autophagic compartment. PMID: 24145164
23. analysis of the role of Dnm2 in the cross talk between endosomal and autophagic pathways and evidence a new role of Dnm2-dependent membrane trafficking in autophagy which may be relevant in DNM2-related human diseases PMID: 22369075
24. Study utilized mouse Dyn2 conditional knockout cells combined with retroviral-mediated reconstitution to mimic heterozygous and homozygous states and characterized cellular phenotypes using quantitative assays for several membrane trafficking events. PMID: 21762456
25. dynamin II may be involved in the transport of vesicles containing collageneous and non-collageneous proteins for dentin formation in odontoblast, suggesting that it is a good nanomolecule as a candidate to regulate the secretion of collagen PMID: 22103132
26. DNM2 plays important roles in the maintenance of adult muscle fibers PMID: 21514436
27. This first mouse model of DNM2-related myopathy shows the crucial role of DNM2 in muscle homeostasis. PMID: 20858595
28. eNOS-dependent dynamin2 S-nitrosylation and invasion of host cells to cause recurrent urinary tract infections. PMID: 21220511
29. Endocytosis of murine norovirus 1 into murine macrophages is dependent on dynamin II. PMID: 20375172
30. Data suggest that the components of the GTPase-GED interface act as an intramolecular signaling module, which we term the bundle signaling element, that can modulate dynamin function in vitro and in vivo. PMID: 19515832
31. These results suggest that hyperoxia induces caveolin-1-dependent, c-Abl-mediated dynamin 2 phosphorylation required for recruitment of p47(phox) to caveolin-enriched microdomains and subsequent ROS production in lung endothelium. PMID: 19833721
32. To define how Dyn2 might participate in actin dynamics in livings cells we have expressed green fluorescent protein (GFP)-tagged Dyn2 in cultured cells and observed labeling of comet-like vesicles and macropinosomes. PMID: 11782546
33. All of these results suggest that the interaction between dynamin II and syndecan-4 is important in mediating focal adhesion and stress-fiber formation. PMID: 15694365
34. results suggest that amphiphysin 1 and dynamin 2 are involved in TBC formation and spermatid release at Sertoli cells PMID: 17785912
35. Dnm2 mediates fluid-phase micropinocytosis in epithelial cells. PMID: 18003703
36. These studies reveal isoform and splice-variant specific functions for Dynamin-2. PMID: 18923138
37. Data suggest that Src activates a negative-feedback loop by promoting both the binding of dynamin to Pyk2-containing complexes and the dynamin-dependent decrease in Pyk2 Y402 phosphorylation, leading to the dissociation of Src from Pyk2. PMID: 19380485
38. Dyn2 contributes to the structural integrity of discoid vesicles and to the endocytic activity of umbrella cells . PMID: 19479281

Show More

Hide All

KEGG: mmu:13430

STRING: 10090.ENSMUSP00000133564

UniGene: Mm.433257