Recombinant Mouse E3 ubiquitin-protein ligase NEDD4 (Nedd4), partial

1. NEDD4 targets an RNA-binding protein, NANOS2, in spermatogonia to destabilize it, leading to cell differentiation. A NEDD4-mediated mechanism regulates mRNP dynamics, and facilitates spermatogonial progenitor cell homeostasis and viability under normal and stress conditions. PMID: 28585553
2. these findings support NEDD4 as a novel regulator of adipogenesis by modulating the stability of PPARgamma. PMID: 27917940
3. expression or dysfunction of Nedd4 E3 ligase could be involved in vascular calcification of VSMCs by activating bone-forming signals during atherosclerosis progression PMID: 28029182
4. Our data suggest that the behavioral sensitivity to stress is dramatically reduced in FXS, opening new views on the impact of gene-environment interactions in this pathology. PMID: 27939692
5. Nedd4-1 is required for efficient internalization of major growth factor receptors involved in liver regeneration and their downstream mitogenic signaling. PMID: 28890072
6. NPM1-dependent nucleolar PIDDosome is a key initiator of the caspase-2 activation cascade. PMID: 28432080
7. these results suggest that Nedd4 suppresses colonic WNT signaling and tumor growth, at least in part, by suppressing the transcription factors LEF1 and YY1. PMID: 27086928
8. Findings indicate that reducing Nedd4 protein by 50% significantly impairs long-term potentiation and long-term memory thereby demonstrating an important role for Nedd4 in these processes. PMID: 26821291
9. Upregulation of long non-coding RNA PAPAS in response to hypoosmotic stress does not increase H4K20me3 because of Nedd4-dependent ubiquitinylation and proteasomal degradation of Suv4-20h2. PMID: 26904956
10. we propose that Nedd4 functions as a novel Pax7 regulator, which activity is temporally and spatially controlled to modulate the Pax7 protein levels and therefore satellite cell fate. PMID: 26304770
11. PDLIM7 is a bona fide skeletal muscle substrate of Nedd4-1. PMID: 26556890
12. show that absence of Nedd4 in pre-osteoblasts results in decreased cell proliferation and altered osteogenic differentiation PMID: 26681395
13. Nedd4 overexpression accelerates zebrafish embryonic growth through IRS-2 in vivo. PMID: 25879670
14. Nedd4 co-injection was found to have no affect on Gag- or Env-specific IFNgamma but had a trend of increased Gag-specific IL-6, IL-17A and TNFalpha that was not seen following Env stimulation. PMID: 24614057
15. NEDD4 is a previously unknown component of the CD40 signalling complex necessary for AKT activation. PMID: 25072696
16. Brucella infection inhibits macrophages apoptosis via Nedd4-dependent degradation of calpain2. PMID: 25258171
17. PTEN limits Nedd4-1 protein levels by modulating the activity of mTORC1, a protein complex that controls protein synthesis and cell growth. PMID: 25157163
18. Rsp5 and its mammalian homologue Nedd4 are important E3 ligases responsible for the increased ubiquitylation induced by heat stress. PMID: 25344756
19. This study is the first to show that a 50% reduction in Nedd4 levels is sufficient to produce significant gait defects in 6 month old mice PMID: 24280120
20. results identify Nedd4 as a novel binding partner for GluN2D and suggest a mechanism for the regulation of NMDA receptors that contain GluN2D subunits through ubiquitination-dependent downregulation PMID: 23639431
21. the expression profile of ubiquitin ligase Nedd4-2 during midcorticogenesis suggests that ubiquitin-mediated alterations in protein levels and protein turnover are required for neuron migration, positioning and maturation. PMID: 24036464
22. An essential role for the ubiquitin ligase Nedd4 in cranial neural crest cell development, is reported. PMID: 24080509
23. This suggests NEDD4-1 functions in conjunction with other post-translational mechanisms to regulate Thoc1 protein and THO activity. PMID: 23460917
24. The results demonstrate that Nedd4-1 plays an important role in mediating denervation-induced skeletal muscle atrophy in vivo. PMID: 23110050
25. Data suggest a role for the ubiquitin ligase Nedd4 in membrane sorting of LAPTM4 proteins. PMID: 22096579
26. Dlg3 exerts a distinct function by recruiting the ubiquitin ligases Nedd4 and Nedd4-2 through its PPxY motifs. These interactions are required for Dlg3 monoubiquitination, apical membrane recruitment, and tight junction consolidation. PMID: 21920314
27. Nedd4-1 interferes with the chaperon role of Ca(v)beta at the endoplasmic reticulum/Golgi level to prevent the delivery of Ca(v) channels at the plasma membrane. PMID: 21220429
28. analysis of the interaction between the growth factor-binding protein GRB10 and the E3 ubiquitin ligase NEDD4 PMID: 20980250
29. Nedd4-1 and beta-arrestin-1 as key regulators of NHE1 ubiquitylation, endocytosis, and function. PMID: 20855896
30. NEDD4-1-mediated PTEN ubiquitination is crucial in the regulation of PI3K/Akt signaling by PTEN during the neuronal response to zinc, which may represent a common mechanism in neurodegeneration PMID: 20100827
31. Nedd4-1 is a suppressor of Tsp1 and increased levels of Tsp-1 in Nedd4-1 knock-out mice may have contributed to the developmental defect observed in the embryos PMID: 20026598
32. These results suggest a role for the Grb10/Nedd4 complex in regulating ubiquitination and stability of the IGF-IR, and they suggest that Grb10 serves as an adapter to form a bridge between Nedd4 and the IGF-IR. PMID: 12697834
33. Results provide evidence that Nedd4 and Nedd4-2 are likely to be key regulators of specific neuronal voltage-gated sodium channels in vivo. PMID: 15123669
34. ubiquinates APOBEC3G targeting the virus assembly site where APOBEC3G interacts with Gag and is packaged into HIV-1 particles in the absence of Vif PMID: 15581898
35. Our data indicate that DeltaNp63alpha is ubiquitinated in a Nedd4- and sumoylated in a Ubc9-dependent fashion, and that these modifications can regulate DeltaNp63alpha stability in the zebrafish ectoderm. PMID: 15908775
36. NEDD4-1 is a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53. PMID: 17218260
37. These results indicate that Grb10 and Nedd4 play a critical role in mediating IGF-IR down-regulation by promoting ligand-dependent multiubiquitination of the IGF-IR, which is required for receptor internalization and regulates mitogenesis. PMID: 18286479
38. results fail to support a role for Nedd4-1 as the E3 ligase regulating PTEN stability and subcellular localization. PMID: 18562292
39. Nedd4 appears to positively control IGF-1 and insulin signaling partly through the regulation of Grb10 function. PMID: 18812566
40. We propose that Nedd4 and Itch ubiquitinate distinct target proteins in vivo. PMID: 18931680
41. these results demonstrate that Nedd4 is involved in regulating the formation and function of the neuromuscular junctions through non-cell autonomous mechanisms. PMID: 19345204

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KEGG: mmu:17999

STRING: 10090.ENSMUSP00000034740

UniGene: Mm.279923