Recombinant Mouse ELAV-like protein 1 (Elavl1)

1. Ectopic expression of HuR in astrocytes worsens outcome after transient ischemic stroke in mice in part by increasing vasogenic cerebral edema PMID: 28982595
2. Hu antigen R (HuR), dictates translation specificity of bound mRNAs and is sufficient to define distinct Foxp-characterized subpopulations of neocortical projection neurons. Distinct phosphorylation states of HuR differentially regulate translation of Foxp mRNAs in vitro. PMID: 27383233
3. Data report that HuR negatively regulates CUGBP1 expression by relocalization to the cytoplasm from the nucleus, which is controlled by different post-transcriptional phosphorylation signaling pathways. These results suggest that HuR acts upstream of CUGBP1 in regulating the expression of genes related to acute myocardial infarction. PMID: 28350193
4. Depletion of CLPABP disturbed the normal subcellular localization of HuR to stress granules, and overexpression of CLPABP induced instability of leptin mRNA by inhibiting HuR function. PMID: 27616329
5. Data (including data from studies using knockout mice or cells from knockout mice) suggest HuR post-transcriptionally regulates Ccr6 expression by binding to and stabilizing Ccr6 mRNA and by promoting Ccr6 translation in helper T-cells; knock-out of HuR reduces Ccr6 expression on helper T-cells, impairs their migration to CNS, and prevents experimental autoimmune encephalomyelitis. (Ccr6 = C-C chemokine receptor type 6) PMID: 28684423
6. Taken together, our results indicate that HuR activation is an early event in familial adenomatosis polyposis (FAP)--adenoma but is not present in inflammatory bowel disease (IBD)-dysplasia. Furthermore, our results offer a preclinical proof of concept for HuR inhibition as an effective means of FAP chemoprevention, with caution advised in the setting of IBD PMID: 28428272
7. findings indicate a previously unknown interaction between GSK3beta and ELAV-1 during acute respiratory distress syndrome , and suggest the inhibition of the ELAV-1- GSK3beta pathways as a novel acute respiratory distress syndrome treatment approach. PMID: 28196122
8. HuR plays a central role in regulating nuclear import of proteins. PMID: 27609837
9. This study uncovers an anti-sense lncRNA (APOA4-AS), which is co-expressed with APOA4, and concordantly and specifically regulates APOA4 expression both in vitro and in vivo with the involvement of HuR. PMID: 27131369
10. Results show that HuR is a key regulator of many genes that make up the molecular signature of activated microglia, including increased production of proinflammatory cytokines, chemokines, and migration-associated factors PMID: 28300326
11. Results indicate that HuR induces 14-3-3zeta translation via interaction with its 3' UTR and that 14-3-3zeta is necessary for stimulation of intestinal epithelial cell migration after wounding. PMID: 27401462
12. Knockdown of endogenous HuR protein abrogates the IL-1beta-mediated increase in xCT mRNA half-life. PMID: 26601945
13. The current data suggested that miR-291b-3p contributed to NCTC1469 cell apoptosis by regulating the expression of HuR, which in turn increased Bcl-2 stability. PMID: 24685524
14. HuR may regulate genes in multiple canonical pathways involved in T cell activation especially the CD28 family signaling pathway. PMID: 26162078
15. HuR acts as a specialized controller of oxidative metabolism in neurons to confer protection from neurodegeneration. PMID: 25301069
16. We show that denervation increases expression of the RNA-binding protein HuR, which in turn, causes an increase in the stability of AChR beta-subunit mRNAs in denervated muscle. PMID: 26245959
17. HuR is essential for normal mucosal growth in the small intestine by altering Wnt signals through up-regulation of LRP6 expression. PMID: 25165135
18. HuR does not play a role in APA of the Hsp70.3 mRNA, and these two regulatory events appear to be mutually exclusive regulators of Hsp70.3 expression PMID: 25727182
19. ELAVL1 antagonized binding of miR-27 to the 3' UTR of Zfp36 mRNA and alleviated miR-27-mediated suppression of ZFP36. PMID: 25533351
20. HuR is essential for the B cell antibody response. PMID: 25706746
21. Conditional knockout of the RNA-binding protein HuR in CD4 T cells reveals a gene dosage effect on cytokine production PMID: 24477678
22. This study identifies a crucial role for HuR in neocortical development as a translational gatekeeper for functionally related mRNA subgroups and polysomal protein specificity. PMID: 25157170
23. ELAVL1-regulated alternative splicing of Eif4enif1 leading to enhanced formation of PB and mRNA turnover constitutes a novel posttranscriptional mechanism critical for pathological angiogenesis PMID: 25422430
24. Results promote the concept of epithelial HuR as a contextual modifier of proapoptotic gene expression in intestinal cancers, acting independently of bile acid metabolism to promote cancer. PMID: 25085247
25. RNA-binding protein HuR protects cells from undergoing senescence. Senescence-associated phenotypes are accelerated in HuR-deficient cells. PMID: 25018007
26. The results indicate that following heat shock treatment, HuR translocates from the nucleus to the cytoplasm, forming stress granules and regulating the translation of IkBalpha mRNA without affecting the half-life. PMID: 24271119
27. The role of HuR in AhR stabilization of Cox-2 mRNA was confirmed by knockdown of HuR, which resulted in rapid Cox-2 mRNA degradation. PMID: 24086407
28. HuR is under the repressive control of miR-133 and the sponging activity of linc-MD1 consolidates HuR expression in a feedforward positive loop. PMID: 24440503
29. these results reveal a HuR-induced posttranscriptional regulatory mechanism of Th17 differentiation that influences IL-17 expression. PMID: 24166976
30. Cytoplasmic HuR appears to play important roles in cell proliferation, progression, and survival of bladder cancer. Its expression was associated with angiogenesis, lymphangiogenesis, and expressions of VEGF-A and -C. PMID: 23516604
31. study shows HuR plays a critical role in IL-17-induced chemokine mRNA stabilization PMID: 23772036
32. analysis of an antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis PMID: 23223443
33. Bile salts stimulate translocation of HuR from the nucleus to the cytoplasm and cytoplasmic HuR regulates c-Myc translation by HuR binding to the 3'-UTR of c-Myc mRNA. PMID: 22626558
34. a novel mechanism by which HuR is regulated by RNPC1 via mRNA stability and HuR is a mediator of RNPC1-induced growth suppression. PMID: 22371495
35. HuR controls translation of some major regulators of cancer progression. PMID: 22215620
36. role of HuR as a homeostatic coordinator of mRNAs that encode molecules that guide innate inflammatory effects PMID: 22201685
37. the RNA-binding protein ELAVL1 is essential for mouse spermatogenesis, the first genetic evidence of ELAVL1 involvement in spermatogenesis PMID: 21737689
38. HuR-driven posttranscriptional control plays a significant role in T cell development and effector function in both transgenic and human systems. PMID: 21613615
39. Our data reveals HuR as the first rna-binding protein identified to play a dominant role in lung development and as a key post-transcriptional regulator of networks guiding tissue remodeling during branching morphogenesis. PMID: 21515253
40. LFA-1-induced stabilization of ARE-containing mRNAs in T cells is dependent on HuR, and occurs through the Vav-1, Rac1/2, MKK3 and p38MAPK signaling cascade PMID: 21206905
41. Hzf and HuR independently associate with the 3'UTR of p53 mRNA and together regulate the translation of p53 mRNA and regulate the nuclear export of p53 mRNA in response to signals that induce p53 activation. PMID: 21402775
42. One of these fragments (HuR-CP1) binds to the HuR import factor transportin-2 (TRN2) allowing HuR to accumulate in the cytoplasm during the transition phase from myoblasts to myotubes. PMID: 20379198
43. HuR plays a causative role in ODC up-regulation during nonmelanoma skin cancer development by binding to and stabilizing the ODC transcript. PMID: 20685649
44. HuR is a direct target of IL-10, and HuR knockdown mimics anti-inflammatory effects of IL-10 PMID: 20219984
45. HuR plays a critical role in inducing inflammatory response of endothelial cells under mechanical and biochemical stresses PMID: 20351266
46. Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-alpha mRNA. PMID: 19949288
47. Upon Elavl1 deletion, progenitor cells in the BM, thymus, and intestine underwent apoptosis, whereas quiescent stem cells and differentiated cells were unaffected. PMID: 19884656
48. mHuR binds to the CD154 ARE. It was found in a extract prepared from murine autoimmune T-cells activated with myelin basic protein & may participate in CD154 expression regulation. PMID: 12686504
49. Our findings underscore a critical function for HuR during skeletal myogenesis linked to HuR's coordinate regulation of muscle differentiation genes. PMID: 12832484
50. increased binding of HuR to the TNFalpha 3'-UTR contributes to increased LPS-stimulated TNFalpha expression in macrophages after chronic ethanol exposure PMID: 12876290

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KEGG: mmu:15568

STRING: 10090.ENSMUSP00000096549

UniGene: Mm.119162