Recombinant Mouse Endothelin-2 (Edn2)

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Edn2

Uniprot No.

P22389

Alternative Names

Edn2Endothelin-2; ET-2; Preproendothelin-2; PPET2; Vasoactive intestinal contractor; VIC

Species

Mus musculus (Mouse)

Expression Region

46-66

Target Protein Sequence

CSCNS WLDKECVYFC HLDIIW

Protein Length

Cytoplasmic domain

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Vasoconstrictor.

Gene References into Functions

Follicle rupture and fertility were significantly impaired in the absence of ovarian Edn2 expression. PMID: 28400616
The results demonstrated that long-term hyperglycaemia in conjunction with VEGF-driven retinal neovascularization increased Edn2 serum concentration suggesting Edn2 might be a candidate biomarker for vascular changes in diabetic retinopathy. PMID: 27482904
EDN2 is necessary for normal ovulation and corpus luteum formation. PMID: 24763822
Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis. PMID: 24043815
Edn2-mediated mechanisms that contribute to PR survival PMID: 23469133
ET-2 is critical for the growth and survival of postnatal mice and plays important roles in energy homeostasis, thermoregulation, and the maintenance of lung morphology and function. PMID: 23676500
Since endothelin 2 is potently vasoconstrictive and was produced by microglia/macrophages, our data provide what we believe to be a novel link between these cell types and vascular dysfunction in glaucoma. PMID: 21383504
These data indicate that ET-2 is a direct target gene of Hedgehog signaling in basal cell carcinoma. PMID: 19914214
sequence analysis and expression; expression level in adults was approx. 10-fold higher than in the foetus, suggesting involvement in intestinal development PMID: 12193061
ET-2 gene expression gradually increases after parturition PMID: 12372435
Regional differences in central nervous sytem and pituitary gland gene expression noted; Cold injury to the mouse cerebral cortex caused decreased expression PMID: 12507500
expression profile & localization in the intestinal tract; results suggest that in intestinal epithelial cells ET-2 could be secreted into the lamina propria & dome region in Peyer's patch & that it might modulate immune cells for mucosal defense PMID: 16216902
EDN2 induces follicular rupture by constricting periovulatory follicles. PMID: 16410304
These results indicate new three findings, (1) ET-2/VIC expression increases and has potential as a differentiation marker. PMID: 17418814
effect of hypoxia on endothelin-2 mRNA expression in granulosa cells at ovulation PMID: 18516093

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Subcellular Location

Secreted.

Protein Families

Endothelin/sarafotoxin family

Database Links

KEGG: mmu:13615

STRING: 10090.ENSMUSP00000030384

UniGene: Mm.284855

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Recombinant Mouse Endothelin-2 (Edn2)

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