Recombinant Mouse Fatty acid-binding protein, adipocyte(Fabp4)

Code CSB-YP007945MO
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Source Yeast
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Code CSB-EP007945MO
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Source E.coli
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Code CSB-EP007945MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP007945MO
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Source Baculovirus
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Code CSB-MP007945MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Fabp4
Uniprot No. P04117
Alternative Names Fabp4; Ap2; Fatty acid-binding protein; adipocyte; 3T3-L1 lipid-binding protein; Adipocyte lipid-binding protein; ALBP; Adipocyte-type fatty acid-binding protein; A-FABP; AFABP; Fatty acid-binding protein 4; Myelin P2 protein homolog; P15; P2 adipocyte protein; Protein 422
Species Mus musculus (Mouse)
Expression Region 2-132
Target Protein Sequence CDAFVGTWK LVSSENFDDY MKEVGVGFAT RKVAGMAKPN MIISVNGDLV TIRSESTFKN TEISFKLGVE FDEITADDRK VKSIITLDGG ALVQVQKWDG KSTTIKRKRD GDKLVVECVM KGVTSTRVYE RA
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
Gene References into Functions
  1. The findings chart the pathway of FABP4 secretion and provide a potential therapeutic means to control metabolic disorders associated with its dysregulated secretion. PMID: 29212659
  2. Study in A-FABP knockout mice revealed that A-FABP acts as a physiological stimulator of brown adipose tissue-mediated adaptive thermogenesis. PMID: 28128199
  3. Fabp4/5 confers protection against metabolic diseases but does not extend lifespan. PMID: 29020626
  4. Ectopic expression and secretion of FABP4 in vascular endothelial cells contribute to neointima formation after vascular injury. PMID: 28903937
  5. FABP4 regulates the expression of BLT1R and its downstream signaling via control of oxidative stress in macrophages PMID: 28546450
  6. Upregulated ROS induced by FABP4 was of significance in activating FoxM1 leading to airway inflammation and epithelial barrier dysfunction. PMID: 29158087
  7. Collectively, these results demonstrate that C. pneumoniae exploits host FABP4 to facilitate fat mobilization and intracellular replication in adipocytes. This work uncovers a novel strategy used by intracellular pathogens for acquiring energy via hijacking of the host lipid metabolism pathway. PMID: 29108997
  8. High Fabp4 expression is associated with Acute myeloid leukemia. PMID: 27885273
  9. These data suggest that the function of SIRT6 in the Fabp4-Cre-expressing cells in addition to mature adipocytes plays a critical role in body weight maintenance and metabolic homeostasis. PMID: 28385723
  10. This study demonstrating a FABP4-UCP2 axis with the potential to modulate the microglial inflammatory response. PMID: 28214555
  11. our data establish A-FABP as a new molecular sensor in triggering macrophage-associated sterile inflammation in obesity. PMID: 27920274
  12. these data offer a novel pathway whereby FABP4/aP2 regulates macrophage redox signaling and inflammasome activation via control of UCP2 expression. PMID: 27795298
  13. FABP4 locally produced by epicardial/perivascular fat and macrophages in vascular plaques contributes to the development of coronary atherosclerosis. PMID: 27013610
  14. endothelial PATZ1 thus potently inhibits endothelial function and angiogenesis via inhibition of FABP4 expression, and abnormal induction of endothelial PATZ1 may contribute to multiple aspects of vascular dysfunction in diabetes PMID: 27297106
  15. These results suggest that the antiinflammatory phenotype of FABP4/aP2 null mice is mediated by increased intracellular monounsaturated fatty acids leading to the increased expression of both uncoupling protein 2 and SirT3. PMID: 26789108
  16. FABP4 could reverse the activation of the leptin-induced mitochondrial fatty acid oxidation. PMID: 26310911
  17. FABP4 is a hypoxia inducible gene that sensitizes mice to liver I/R injury. PMID: 26070408
  18. Data suggest Fabp4 is up-regulated and DNA methylation is down-regulated in aorta in hyperhomocysteinemia induced by high-methionine diet; up-regulation of DNA methyltransferase 1 (Dnmt1) promotes DNA methylation and decreases Fabp4 expression. PMID: 26606905
  19. Data show that the weight gain was blunted in male, but not female, fatty acid binding protein 4-Cre-driven promoter (FaChOX) mice when placed on either a normal chow diet or an obesogenic Western diet. PMID: 26248218
  20. Data show that overexpression of cattle adipocyte fatty acid-binding protein (A-FABP)gene promoted fat deposition in the skeletal muscle of transgenic mice. PMID: 25867423
  21. Data suggest that expression of Fabp4 (fatty acid binding protein 4) in preadipocytes is up-regulated by arachidonic acid during adipogenesis; this up-regulation appears mediated by prostaglandin F2alpha/FP (prostaglandin F2alpha receptor) signaling. PMID: 25325755
  22. results show that chemical inhibition of lipase activity, genetic deficiency of adipose triglyceride lipase and, to a lesser extent, hormone-sensitive lipase blocked aP2 secretion from adipocytes. PMID: 25535287
  23. FABP4-/- mice demonstrated a significant decrease in neovessel formation and significant improvement in physiological revascularization. PMID: 24802082
  24. A-FABP deficiency protects mice against MI/R-induced and/or diabetes-induced cardiac injury at least partially through activation of the eNOS/NO pathway and reduction in superoxide anion production PMID: 26186740
  25. -). As Cre-loxP-mediated genetic lineage tracing is irreversible and heritable, the genetic labelling (RFP) would inevitably label all descendants of these early FABP4+ embryonic VECs, regardless of whether they express CreER at P7 or not. PMID: 25265869
  26. FABP4 is expressed in the mouse placental labyrinth, with highest expression at E16.5. FABP4 is dispensable for feto-placental growth and placental lipid accumulation. PMID: 25096952
  27. The present results demonstrate that deletion of IL-6 driven by a fatty acid binding protein (aP2) promoter-Cre inducible system regulates body weight, body fat and metabolism in a sex-specific fashion. PMID: 24934978
  28. miR-24 plays an important role in regulating adipocyte differentiation and FABP4 expression. The mechanism involved may be the upregulation of AP-1. PMID: 24301787
  29. FABP4/5 play an indispensable role in thermogenesis in brown adipose tissue and skeletal muscle. PMID: 24603714
  30. peripheral uptake of FA via capillary endothelial FABP4/5 is crucial for systemic metabolism and may establish FABP4/5 as potentially novel targets for the modulation of energy homeostasis. PMID: 24244493
  31. In aP2-Cre/ERalpha(flox/flox) mice, increased serum estrogen levels cause over-stimulation in the uterus. PMID: 24416430
  32. found that the FABP4 level was higher and PPARgamma level was lower in human visceral fat and mouse epididymal fat compared with their subcutaneous fat PMID: 24319114
  33. Neutralization of secreted aP2 reduces glucose production. PMID: 23663740
  34. lower dermis adipose layer development is signalled by expression of FABP4 PMID: 23555789
  35. Capillary endothelial FABP4/5 are required for (fatty acid)FA transport into FA-consuming tissues that include the heart. PMID: 23968980
  36. High Fabp4 expression is associated with atherosclerotic lesion. PMID: 23387955
  37. FABP4 promotes VEGF-induced airway angiogenesis. PMID: 23391391
  38. FABP4 expression in adipose and hepatic tissues in the settings of obesity and insulin resistance, was analyzed. PMID: 23139800
  39. fatty acid binding protein 4 (FABP4), commonly known as adipocyte protein 2 (aP2), has been extensively used as a marker for differentiated adipocytes. However, whether aP2 is expressed in adipogenic progenitors is controversial PMID: 23047894
  40. These findings indicate that FABP4 may have a crucial role in modulating IL-6 and vascular endothelial growth factor as angiogenesis inducers stimulated by the cellular action of thrombin on adipocytes via PAR1. PMID: 23008513
  41. fatty acid-binding protein (FABP4), an intracellular fatty acid chaperone, in the mouse thymus, and examined its role in the control of cytokine production PMID: 22585040
  42. In the aP2-Cre mice, the recombinase activity is expressed in the central nervous system of the embryos. PMID: 22150821
  43. Report statins/dexamethasone synergistically induce FABP4 expression in macrophages. PMID: 22503826
  44. Unsaturated fatty acids inhibited the basal as well as lipopolysaccharides induced Adipocyte fatty acid binding protein expression. PMID: 21046125
  45. Fabp4 is highly expressed in mouse decidua. In vitro decidualization is significantly stimulated by Fabp4 overexpression and inhibited by Fabp4 siRNA and FABP4 inhibitor. PMID: 21704217
  46. Results define a new class of in vivo ligands for aP2 and other fatty acid binding proteins and extend their physiological substrates to include bioactive aldehydes. PMID: 20509169
  47. The lack of aP2 in donor marrow cells led to the development of smaller (5.5-fold) atherosclerotic lesions in the recipient mice. PMID: 11606480
  48. data provide support for the portal region hypothesis and suggest dynamic fluctuations in this region regulate cavity access, but not ligand affinity or selectivity PMID: 11827549
  49. Ap2-deficient mice with advanced atherosclerosis and severe hypercholesterolemia fed a Western diet for 14 weeks have significant reductions in mean atherosclerotic lesion size in the proximal aorta, en face aorta, and innominate/right carotid artery. PMID: 12377750
  50. A-FABP and E-FABP bind to hormone-sensitive lipase with high affinity PMID: 13129924

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Subcellular Location Cytoplasm, Nucleus
Protein Families Calycin superfamily, Fatty-acid binding protein (FABP) family
Database Links

KEGG: mmu:11770

STRING: 10090.ENSMUSP00000029041

UniGene: Mm.582

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