Recombinant Mouse GTP-binding protein Rheb (Rheb)

1. This study found that cRheb expression promoted regeneration of injured rVRG axons into the lesion site, while we observed no rVRG axon regrowth with AAV2-GFP control. PMID: 29453976
2. Rheb1 is critical for the polarization of macrophages and inhibition of allergic asthma. Deletion of Rheb1 enhances M2 polarization but decreases M1 polarization in alveolar macrophages, leading to the aggravation of OVA-induced allergic asthma. PMID: 28225024
3. Ggpps deletion enhanced Rheb farnesylation, which subsequently activated mTORC1 and facilitated spermatogonial differentiation PMID: 27374985
4. Thus, the various regulatory elements that impinge upstream of mTORC1 activation pathways are differentially required for HSC homeostasis in vivo. PMID: 29175333
5. Forebrain depletion of Rheb GTPase elicits spatial memory deficits. PMID: 27960107
6. Rheb is an important negative regulator of beige fat development and thermogenesis. Rheb is able to suppress the beiging effect through an mTORC1-independent mechanism, via PDE4D5-dependent downregulation of the cAMP-PKA signaling pathway. PMID: 28242620
7. Rheb and TSC2 have roles in the mechanical activation of mTOR signaling PMID: 28289099
8. Rheb1 is critical for macrophage production and phagocytosis and executes these activities possibly via mTORC1-dependent pathway. PMID: 27163399
9. EAAT4 was downregulated due to the loss of Rheb1 in Purkinje cells; mTORC1 was downregulated and Akt was upregulated in Rheb1 cKO mice, suggesting that mTORC1 and Akt may be related to the downregulation of EAAT4; Rheb1 knockout decreased EAAT4 currents and slowed down the kinetics of AMPA currents; Rheb1 deficiency did not affect the morphology of Purkinje cell layer and the development of Purkinje cells PMID: 26194056
10. The expression pattern of RHEB1 suggests that it likely plays a ubiquitous role in the development of the early embryo with more tissue-specific roles in later development. PMID: 26708151
11. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway. PMID: 27071307
12. Rheb activation disrupts neuronal spine synapse formation via syntenin accumulation in tuberous sclerosis complex. PMID: 25880340
13. We conclude that in contrast to TORC1 hyper-activity, cognitive function is not very sensitive to sustained and specific down-regulation of TORC1 activity. PMID: 25759467
14. Rheb protein was mainly detected in apoptotic retinal ganglion cells following light injury. PMID: 24664437
15. PDK4 promotes tumorigenesis through activation of the CREB-RHEB-mTORC1 signaling cascade. PMID: 25164809
16. We conclude that oligodendrocyte progenitor cells-intrinsic mTORC1 activity mediated by Rheb1 is critical for differentiation of oligodendrocyte progenitor cells PMID: 25411504
17. The small GTPase Rheb is required for spermatogenesis but not oogenesis. PMID: 24713393
18. The paper proposed a novel pathway/mechanism involving Rheb/mTORC1/S6K signaling to explain how C2-ceramide impairs insulin signaling via Akt phosphorylation. PMID: 24650522
19. whereas rapid adaptation in mTORC1 activity requires Rheb, a second Rheb-independent activation mechanism exists that contributes to cell cycle progression. PMID: 24303063
20. deletion of Rheb1 in the brain causes a reduction in mTORC1 activity and impairs food intake. PMID: 24451134
21. miR-155 bound to the 3'-untranslated region of Ras homologue enriched in brain (Rheb), a negative regulator of autophagy, accelerated the process of autophagy and sequential killing of intracellular mycobacteria by suppressing Rheb expression. PMID: 24130493
22. study defines Rheb as a novel physiological regulator of BACE1 levels and Abeta generation, and the Rheb-BACE1 circuitry may have a role in brain biology and disease. PMID: 24368770
23. Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period PMID: 23426372
24. Newborn Rheb-expressing neurons display altered distribution in olfactory bulb. PMID: 23392671
25. Opposing functions of Rheb Tyr35 in the intrinsic and GAP-stimulated GTP catalysis are critical for optimal mTORC1 regulation. PMID: 22819219
26. Treatment with FTS decreased Ras.GTP only slightly in the TSC2-null cells, but reduced their overactive Rheb as well as their proliferation, migration and tumor growth. PMID: 21500191
27. Inactivation of Rheb protects cardiac myocytes during energy deprivation through activation of autophagy. PMID: 22294621
28. Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway. PMID: 21784859
29. in NOD mice, a model of spontaneous autoimmune T1D, Rheb overexpression significantly accelerated diabetes progression. PMID: 21513702
30. Rheb(-/-) embryonic fibroblasts showed decreased TORC1 activity, were smaller, and showed impaired proliferation PMID: 21321084
31. Rheb1 is essential for mTORC1 signaling and myelination in the brain PMID: 21238928
32. results suggest a novel regulatory mechanism for mTORC1 in which the cAMP-determined dynamic interaction between Rheb and PDE4D provides a key, unique regulatory event, and propose a new role for PDE4 as a molecular transducer for cAMP signaling. PMID: 20837708
33. integrity of late endosomes is essential for amino acid- and insulin-stimulated mTORC1 signaling and blocking the early/late endosomal conversion prevents mTOR from interacting with Rheb in the late endosomal compartment PMID: 20053679
34. RHEB is an MTOR activator that facilitates multistage carcinogenesis through induction of multiple oncogenic mechanisms PMID: 20388784
35. It activates mTorc1. (review) PMID: 20058701
36. ERas and Rheb are two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway; ERas is localized at the plasma membrane, while Rheb is on endomembranes. PMID: 16046393
37. ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo PMID: 18650380
38. Inhibition of PI3K or mTOR reduced the level of Rap1B, which acts downstream of Rheb and mTOR. The ubiquitin E3 ligase Smurf2 mediates the restriction of Rap1B by initiating its degradation. PMID: 18842593
39. This study reveals a function of Rheb in controlling misfolded protein metabolism by modulating aggresome formation. PMID: 19458266

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KEGG: mmu:19744

STRING: 10090.ENSMUSP00000030787

UniGene: Mm.319175