Recombinant Mouse Glutathione peroxidase 3 (Gpx3)

Code CSB-YP009868MO
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Source Yeast
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Code CSB-EP009868MO
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Source E.coli
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Code CSB-EP009868MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP009868MO
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Source Baculovirus
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Code CSB-MP009868MO
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Gpx3
Uniprot No.
Alternative Names
Gpx3Glutathione peroxidase 3; GPx-3; GSHPx-3; EC 1.11.1.9; Plasma glutathione peroxidase; GPx-P; GSHPx-P
Species
Mus musculus (Mouse)
Expression Region
25-226
Target Protein Sequence
QEKSKT DCHGGMSGTI YEYGALTIDG EEYIPFKQYA GKYILFVNVA SYUGLTDQYL ELNALQEELG PFGLVILGFP SNQFGKQEPG ENSEILPSLK YVRPGGGFVP NFQLFEKGDV NGEKEQKFYT FLKNSCPPTA ELLGSPGRLF WEPMKIHDIR WNFEKFLVGP DGIPVMRWYH RTTVSNVKMD ILSYMRRQAA LSARGK
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
Gene References into Functions
  1. the antioxidant enzyme GPX3 localizes to lung extracellular matrix and is variably upregulated in interstitial lung diseases. PMID: 27435875
  2. These results suggest that GPx3 is an important factor for inhibition of Acetaminopheninduced hepatotoxicity both in vivo and in vitro. PMID: 28677736
  3. GPX3 promoter methylation predicts colorectal carcinoma sensitivity to platinum. PMID: 27918237
  4. Results indicate that selenoprotein P (Sepp1) is important for this transport in selenium-replete mice but that glutathione peroxidase-3 (Gpx3) is not. PMID: 25068390
  5. GPx3 may have a possible role in modulating prostate carcinogenesis. PMID: 21374652
  6. Sepp1(UF) and small selenium-containing proteins are filtered by the glomerulus and taken up by PCT cells via megalin-mediated endocytosis, preventing loss of selenium in the urine and providing selenium for the synthesis of glutathione peroxidase-3 PMID: 24434121
  7. GPX3 may play a major role in reducing hydrogen peroxide during decidualization. PMID: 24631040
  8. an immunomodulatory role for GPX3 that limits the development of colitis-associated carcinoma. PMID: 23221387
  9. We applied X-ray fluorescence microscopy to image selenium in mammalian tissues and identified a highly localized pool of this trace element at the basement membrane of kidneys that was associated with GPx3 PMID: 21854231
  10. These results show that glutathione peroxidase 3 from the blood binds to basement membranes of specific epithelial cells and indicate that the cells modify their basement membranes to cause the binding. PMID: 21493731
  11. GPx-3 deficiency results in a prothrombotic state and vascular dysfunction that promotes platelet-dependent arterial thrombosis PMID: 21518981
  12. Inflammatory injury in the intestine elicits an increase in E-GPx in the plasma that is associated with an increase in E-GPx mRNA in the kidney. This implies that renal production of E-GPx may be sensitive to insults distal to the kidney. PMID: 11978890
  13. The expression of Gpx3 decreased at the aortic sinus in a murine model of high-fat diet-induced atherogenesis. PMID: 16508038
  14. GPX-3 may play a significant role in protecting cardiomyocytes from oxidative stress caused by hyperglycemia PMID: 16651743
  15. This is the first report that a particular isotype of the glutathione peroxidase family is regulated by TCDD at both mRNA and protein levels PMID: 16682824
  16. c-maf may be transcriptional regulator of GPx3 expression and modulate the antioxidative pathway in the kidney PMID: 16890189
  17. GPx3 expression was reduced selectively in the adipose tissue of several obese animal models as decreasing plasma GPx3 level. PMID: 18562625

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Subcellular Location
Secreted.
Protein Families
Glutathione peroxidase family
Tissue Specificity
Secreted in plasma.
Database Links
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