Recombinant Mouse Heart- and neural crest derivatives-expressed protein 1 (Hand1)

1. Somatically acquired Hand1A126FS mutation is not causative of hypoplastic left heart syndrome PMID: 29016838
2. a non-essential role for Hand1 in mouse limb morphogenesis, is reported. PMID: 28576769
3. Surviving Hand1;Hand2 mutants display diminished cardiac function that is rescued by concurrent ablation of Hand-null cardiomyocytes. Collectively, we conclude that, within a mixed cardiomyocyte population, removal of defective myocardium and replacement with healthy endogenous cardiomyocytes may provide an effective strategy for cardiac repair. PMID: 28732025
4. Within the pharyngeal arches, the distal-most of the proximo-distally oriented subdomains of cranial neural crest cells, the distal cap, is marked by expression of the transcription factor Hand1 and gives rise to the ectomesenchymal derivatives of the lower incisors. PMID: 27335460
5. Data suggest the protection role of haploinsufficiency of heart and neural crest derivatives expressed transcript 1 protein (Hand1) after acute myocardial infarction (AMI). PMID: 27601324
6. Hand1 is involved in proper osteogenesis of the bone collar via its control of Ihh. Hand1 overexpression in the osteochondral progenitors caused defective prenatal diaphysis ossification. Hand1 inhibited Runx2 transactivation of the Ihh proximal promoter. PMID: 26918743
7. Re-expression of HAND1 in colon cancer cells induces terminal differentiation. PMID: 25032847
8. Hand1 phosphoregulation in the distal arch neural crest has a critical role in craniofacial morphogenesis PMID: 25053435
9. Suggest that prenatal alcohol exposure causes the over-expression of DHAND and EHAND by increasing H3K14ac in the fetal heart. PMID: 24857828
10. Hand1 is part of a novel regulatory pathway linking cardiac oxygen levels with oxygen consumption. PMID: 24086110
11. that Hand1 homodimer plays a dominant role during development and its expression dosage is critical for survival, whereas Hand1 heterodimers can be either dispensable or play a regulatory role to modulate the activity of Hand1 homodimer in vivo. PMID: 23911935
12. Hand1-mediated activation of Tbeta4 is essential for yolk sac vasculogenesis and embryonic survival, and administration of synthetic TB4 partially rescues yolk sac capillary plexus formation in Hand1-null embryos. PMID: 20975697
13. Data define a critical threshold of Hand1 expression that is necessary for embryonic survival. PMID: 20737509
14. Results show that Hand1 regulates development of lateral mesoderm derivatives and its loss in extraembryonic mesoderm is the primary cause of lethality in Hand1-null embryos. PMID: 20506548
15. Hand1-driven Cre marks specific lineages within the extra embryonic tissues, placenta, sympathetic nervous system, limbs, jaw, and several cell types within the cardiovascular system. PMID: 20882677
16. expressed in the adult-rodent heart and is modulated during cardiac hypertrophy PMID: 12359233
17. eHAND expression may be related to the anteroventral identity of the mesoderm. PMID: 12666206
18. These data indicate that Hand1 is required for angiogenesis and vascular smooth muscle recruitment in the yolk sac. PMID: 15073150
19. CLP-1 and the HAND transcription factors may be part of a genetic program critical to proper heart development, and their perturbation can lead to cardiomyopathy PMID: 15172687
20. Hand1 and Stra13 promote cell cycle exit and restrict cells towards the Trophoblast Giant cell fate. PMID: 15196947
21. Hand factors play pivotal and partially redundant roles in cardiac morphogenesis, cardiomyocyte differentiation and cardiac-specific transcription PMID: 15576406
22. MEF2/HAND1 interaction results in synergistic activation of MEF2-dependent promoters, and MEF2 binding sites are sufficient to mediate this synergy PMID: 16043483
23. increased transcriptional activity of Hand1 caused by Sox15 might promote the transcription of the target gene resulting in the trophoblast giant cell differentiation in the mouse placenta PMID: 16759287
24. Hand1 is a crucial cardiac regulatory protein that controls the balance between proliferation and differentiation in the developing heart. PMID: 17050624
25. the importance of Hand1 transcription factor in the transcriptional circuitry of craniofacial and tooth development PMID: 17764670
26. Study shows nucleolar sequestration of Hand1 accompanies sustained cell proliferation and renewal, whereas release of Hand1 into the nucleus leads to its activation, thus committing cells to a differentiated giant-cell fate. PMID: 17891141
27. Hand1 is expressed in apical cells lining maternal blood spaces. PMID: 18448564
28. Expression of HAND1 is maintained in sympathetic neurons throughout fetal and postnatal development when these neurons depend on nerve growth factor for survival. PMID: 18724272
29. HMGA1 proteins bind directly to Hand1 promoter both in vitro and in vivo and inhibit Hand1 promoter activity PMID: 19060921
30. Overexpression of Hand1 in the adult mouse heart leads to mild cardiac hypertrophy and a reduction in life expectancy. elevated HAND1 may provide one of the molecular links between the failing heart and arrhythmia. PMID: 19376125

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KEGG: mmu:15110

STRING: 10090.ENSMUSP00000046999

UniGene: Mm.4746