Recombinant Mouse Hepatocyte nuclear factor 4-alpha (Hnf4a)

1. the tight conjunction of G4s and an adjacent stem-loop within the Hnf4a1 5' UTR was both necessary and sufficient to mediate the very strong translational repression. PMID: 29332143
2. PRMT1 inhibition, such as induced by alcohol, may result in epigenetic changes leading to loss of Hnf4alpha. This effect may contribute to alcohol's ability to promote liver tumors PMID: 29023917
3. this study shows that diabetes-linked transcription factor HNF4alpha regulates maminotransferase 2etabolism of endogenous methylarginines and beta-aminoisobutyric acid by controlling expression of alanine-glyoxylate PMID: 27752141
4. These results indicate a critical and conserved role for HNF4A in maintaining intestinal homeostasis in response to microbiota. PMID: 28385711
5. HNF4alpha is required for recruitment of the HDAC3-PROX1 module in liver. PMID: 28916805
6. In summary, HNF4alpha isoforms perform non-redundant functions in the colon under conditions of stress, underscoring the importance of tracking them both in colitis and colon cancer. PMID: 27166517
7. Hnf4alpha silencing with shRNA transfection into auditory neuroblast cells (VOT-33) reduced cell viability PMID: 27112738
8. both iron-dextran injection and a 3% carbonyl iron-containing diet led to upregulation of hepatic inflammation, which was associated with a significant reduction in HNF4alpha expression and its downstream target, miR-122. PMID: 28655781
9. Tg737 regulates a Wnt/beta-catenin/Snail-HNF4alpha negative feedback circuit, thereby blocking EMT and the malignant transformation of liver stem cells to liver cancer stem cells. PMID: 28536011
10. Down regulation of HNF4 alpha plays a role in metabolic liver function and the pathogenesis of liver cancer. PMID: 28295475
11. Fibrotic levels of matrix stiffness significantly inhibit hepatocyte-specific functions in part by inhibiting the HNF4alpha transcriptional network mediated through the Rho/Rho-associated protein kinase pathway. PMID: 26755329
12. key role in controlling hepatic CES2 expression in diabetes, obesity, or nonalcoholic steatohepatitis PMID: 26806650
13. These findings reveal a novel HNF4alpha network controlled by miR-194/192 that may play a critical role in maintaining the hepatocyte-differentiated state by inhibiting expression of genes involved in dedifferentiation and tumorigenesis. PMID: 28465351
14. HNF4alpha regulates homeostatic proliferation in the gastric epithelium and is both necessary and sufficient for the upstream regulation of the Xbp1-->Mist1 axis in maintenance of zymogen cell secretory architecture. PMID: 27340127
15. These results suggest that down-regulation of HNF4alpha could be of importance in beta-cell dysfunction by hypoxia. PMID: 28364040
16. Hnf4a expression during embryonic stem cell differentiation PMID: 27233607
17. HNF-4alpha regulated miR-122 contributes to development of the gluconeogenic and lipid metabolism alterations observed in Type 2 diabetic mice and in palmitate-treated HepG2 cells PMID: 27592052
18. The results revealed the novel mechanism by which HNF-4alpha promoted ChREBP transcription in response to glucose, and also demonstrated that ChREBP-alpha and HNF-4alpha synergistically increased ChREBP-beta transcription. PMID: 27029511
19. Berberine has an effect on hepatic gluconeogenesis and lipid metabolism and is mediated through HNF-4alpha and regulated downstream of miR122 PMID: 27011261
20. Diminished XBP1 and/or HNF4alpha in beta-cells led to impaired endoplasmic reticulum calcium homeostasis. PMID: 26792861
21. In conclusion, our study revealed a novel mechanism by which TSH regulated the hepatic HNF-4alpha subcellular localization. PMID: 26302721
22. an integrated analytic strategy was applied to identify the HNF4alpha-centered regulatory network. PMID: 26279436
23. Tfr2 is a novel target gene for HNF4alpha, and hepatic HNF4alpha plays a critical role in iron homeostasis. PMID: 26527688
24. The miR-34a-HNF4alpha pathway is activated under common conditions of metabolic stress and may have a role in the pathogenesis of NAFLD and in regulating plasma lipoprotein metabolism. PMID: 26100857
25. FOXA3 and HNF4alpha are powerful transcription factors for inducing rat bone marrow mesenchymal stem cells to differentiate into functional hepatocyte-like cells. PMID: 25896100
26. HNF4a is involved in the downregulation of SHBG during obesity development. PMID: 26441241
27. Results showed that HNF4a is highly expressed in brain of mouse model of major depression suggesting that this gene may be both essential for life and have a critical impact on physiological homeostasis under depressive status. PMID: 25774879
28. These results suggest that the flavonoid luteolin ameliorates an atherogenic lipid profile in vivo that is likely to be mediated through the inactivation of HNF4alpha. PMID: 26272613
29. these data demonstrate that copper-mediated nuclear receptor dysfunction disrupts liver function in WD and potentially in other disorders associated with increased hepatic copper levels. PMID: 26241054
30. HNF4alpha maintains hepatocyte identity by regulating miR-29a and -29b expression, which in turn control epigenetic modifications by limiting DNMT3A and DNMT3B levels. PMID: 26003733
31. HNF4alpha reprograms alpha cells to beta-like cells. PMID: 25224487
32. Local promoter-proximal HNF4A-TFIID interactions therefore act as instructive signals for post-natal hepatocyte differentiation. PMID: 25209997
33. Cyp2d40 is induced during pregnancy through enhanced transactivation by HNF4alpha. PMID: 25598084
34. Despite reduced HNF4A binding during inflammation, a temporal knockout model revealed HNF4A still actively protects against inflammatory phenotypes and promotes immune regulatory gene expression in the inflamed colonic epithelium. PMID: 24980432
35. transgenic mouse models expressing mutant IDH in the adult liver show an aberrant response to hepatic injury, characterized by HNF-4alpha silencing, impaired hepatocyte differentiation, and markedly elevated levels of cell proliferation PMID: 25043045
36. HNF4alpah defines kidney-specific androgen receptor recruitment. It is constitutively bound to chromatin and guides AR to specific genomic loci upon hormone exposure. PMID: 24451200
37. roles for PPARalpha and HNF4alpha in stress-induced lipid metabolism PMID: 23967086
38. Data indicate that cholesterol sulfate (CS) and SULT2B1b inhibited gluconeogenesis by targeting the gluconeogenic factor hepatocyte nuclear factor 4alpha (HNF4alpha) in both cell cultures and human SULT2B1b transgenic mice. PMID: 24277929
39. Fxr cooperates with Hnf4alpha in the liver to modulate gene transcription. PMID: 23462932
40. the data strongly supports a critical role for HNF4a and Hnf1a in the tissue-specific regulation of drug handling and differentiation toward a PT-like cellular identity. PMID: 24038112
41. critical for inhibition of hepatic proliferation, suggesting a novel role as a tumor suppressor PMID: 23315968
42. The induction of lipin 1 by HNF4alpha may serve as a mechanism to affect promoter selection to direct HNF4alpha to promoters of genes encoding fatty acid oxidation enzymes. PMID: 23236470
43. HNF4-1 and MAZ-1 regulate the expression of Rho-GDIgamma and contribute to the differentiation of neural stem cells. PMID: 22944911
44. The Pkd1/Hnf4alpha double mutants have significantly more cystic kidneys, thus indicating that metabolic pathways could play a role in Pkd1-cystogenesis PMID: 23209428
45. apart from its role in hepatocyte differentiation, HNF4alpha actively inhibits hepatocyte proliferation by repression of specific promitogenic genes PMID: 23104559
46. the identification of MED25 as one of the HNF4alpha binding partners in pancreatic ss-cells leading to insulin secretion which is impaired in MODY patients PMID: 22952853
47. Zinc-enhanced liver regeneration is associated with an increase in HNF-4alpha, which may have beneficial effects in alcoholic liver disease. PMID: 22493904
48. HNF4alpha bound to a central domain of cyclin D1 involved in transcriptional repression. PMID: 22751438
49. The role of HNF4alpha in induction and maintenance of hepatocyte differentiation should also be ascribed to its capacity to continuously repress the mesenchymal program. HNF4alpha activator and repressor functions are necessary for the identity of hepatocytes. PMID: 21384409
50. Mucroporin-M1 peptide can activate the MAPK pathway and then reduce the expression of HNF4alpha, resulting in the inhibition of HBV replication in vitro and in vivo. PMID: 22791717

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KEGG: mmu:15378

STRING: 10090.ENSMUSP00000018094

UniGene: Mm.202383