Recombinant Mouse High affinity immunoglobulin epsilon receptor subunit gamma (Fcer1g), partial

1. CD23 deficiency impacts the early cellular event of B-cell receptor (BCR) activation. PMID: 27181049
2. Dock10 negatively regulates membrane CD23 expression; negative regulation of CD23 expression by Dock10 could play a role in B cell maturation and function PMID: 27502165
3. data are significant in uncovering a latent, but potent, negative-regulatory role for Myd88 and Fcer1g in the late stages of B cell responses; such roles could limit acute responses; however, they could be particularly significant in chronic responses, such as autoimmunity and chronic infection PMID: 28659358
4. FcgammaR-mediated Syk activation leads to NLRP3 inflammasome-dependent IL-1beta production in macrophages and suggests that an Nlrp3- and IL-1R-dependent process contributes to the IgA response important for protection against Francisella tularensis LVS. PMID: 27365531
5. this study reveal an autonomous membrane IgE signaling mechanism that normally prevents IgE(+) memory B cells and long-lived plasma cells formation, providing insights into the molecular pathogenesis of allergic diseases. PMID: 27428827
6. Galectin-3 regulates IgE receptor signaling in mast cells. PMID: 26929198
7. these results identify a previously unproven mechanism in which epithelial CD23 plays a central role in the development of allergic inflammation PMID: 25783969
8. In mast cells, ORMDL3 functions predominantly as a negative regulator of FcepsilonRI-mediated signaling events leading to the expression of proinflammatory mediators and chemotaxis. PMID: 26407610
9. Data show that although phospholipase D PLD1 deficiency impaired Fc epsilon receptor FcepsilonRI-mediated signaling and mast cell function, phospholipase D PLD2 deficiency actually enhanced these pathways. PMID: 26392467
10. Glomerulonephritis in FcRgamma-/- chimeras was no different from wild type. PMID: 25565310
11. Acidic pH augments Fc-epsilon-RI-mediated production of IL-6 and IL-13 in mast cells. PMID: 26196745
12. Canonical tyrosine residues mutation in FceRIg ITAM (Y65 and Y76) reveals that these two tyrosine residues in gamma subunit are required for its interaction with type II PtdIns 4-kinases. PMID: 24481753
13. Data indicate that phosphorylation of Tyr114 and Tyr259 of prohibitin (PHB) is critical for the association of PHB with FcRI and Syk. PMID: 24023254
14. critical for TGFbeta2-treated macrophage-induced tolerance PMID: 23643295
15. plays role in beta2 adrenergic receptor-induced increase in IgE on B cells PMID: 24140643
16. the CD23 surface level and serum IgE level are uncoupled and that neither is directly regulated by the mutations within the CD23 coding region. PMID: 23646151
17. these data reveal a novel role for FcRgamma in promoting peripheral T cell apoptosis in Fas-deficient mice, which may be of significant value in understanding autoimmune lymphoproliferative syndromes. PMID: 23313147
18. Fcgamma receptor deficiency attenuates diabetic nephropathy in mice. PMID: 22859852
19. Low affinity IgE competes with high affinity IgE for binding to Fcepsilon receptors and prevents anaphylaxis and is thus beneficial. PMID: 22249450
20. Rab35 regulates phagosome formation through recruitment of ACAP2 in macrophages during FcgammaR-mediated phagocytosis. PMID: 22045739
21. regulates T helper cell differentiation through FcgammaRIII mediated dendritic cell cytokine modulation PMID: 20494341
22. Experiments with knockout mice show that the high-affinity FC receptors for IGG and IGE are necessary for Brugia microfilaria clearance. PMID: 11920579
23. data indicate that ligation of Fcgamma receptors activates Lyn followed by Syk kinase during phagocytosis PMID: 12056610
24. that CD23 on murine Langerhans cells may be involved in IgE-mediated immune responses. PMID: 12164935
25. Fc epsilon RI gamma-mediated signals differentially regulate the receptor expression, activation, and survival of mast cells and systemic anaphylaxis. PMID: 14764707
26. FcRgamma-mediated signal transduction is involved in osteoclast differentiation. PMID: 15184345
27. LAB shares a redundant function with LAT to play a positive role in FcepsilonRI-mediated signaling. PMID: 15477350
28. These results demonstrate that expression of FcRgamma, most likely FcgammaRI, on APCs is important during the sensitization phase for the development of allergic airway inflammation and airway hyperresponsiveness. PMID: 17182587
29. These results suggest that the restoration of FcRgamma/Fyn signaling represents a new approach for the treatment of demyelinating diseases. PMID: 17290413
30. Fc receptors gamma chain may play the pivotal role in endothelial dysfunction through oxidative stress induced by hypercholesterolaemia. PMID: 18694873
31. Data show that a pathway involving Fgr, DAP12 and FcRgamma is involved in the initial signaling events downstream of E-selectin-engaged PSGL-1 that are required to initiate neutrophil slow rolling. PMID: 18794338
32. Data suggest that flagellin-specific IgG/Fc gamma receptor I complex immune responses activate mast cells in the intestine and play important roles in the pathogenesis of intestinal immune inflammation. PMID: 18974296
33. Suppression of experimental immune thrombocytopenic purpura by human C-reactive protein (CRP)-treated splenocytes requires Fc gamma receptor type I on the donor macrophage and Fc gamma receptor type IIb in the recipient mice. PMID: 19155486

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KEGG: mmu:14127

STRING: 10090.ENSMUSP00000078875

UniGene: Mm.22673