Recombinant Mouse Inositol 1,4,5-trisphosphate receptor type 1 (Itpr1), partial

1. The results of first study associating IP3R1 activity with changes in autophagy, mitochondrial Ca2+ levels, mitochondrial membrane potential, mitochondrial dynamics, and mitophagy in adult mouse skeletal muscle suggest that increased IP3R activity in mdx fibers plays an important role in the pathophysiology of Duchenne muscular dystrophy. PMID: 30251688
2. Tespa1 functions in T cell development and the regulation of TCR-induced Ca(2+) signalling through IP3R1 PMID: 28598420
3. Inositol 1,4,5-trisphosphate receptors (IP3Rs) are required for the hematopoietic and cardiac fate divergence of mouse embryonic stem cells. Deletion of IP3Rs (IP3R-tKO) reduced Flk1+/PDGFRalpha- hematopoietic mesoderm, c-Kit+/CD41+ hematopoietic progenitor cell population, and the colony-forming unit activity, but increased cardiac progenitor markers as well as cardiomyocytes. PMID: 28419336
4. Data show that endothelial cells (ECs)-specific type 1 1,4,5-trisphosphate receptor knockout (IP3R1(-/-)) mice are hypertensive and display blunted vasodilation in response to acetylcholine (ACh). PMID: 27402766
5. Cone-specific gene deletion of the inositol-1,4,5-trisphosphate receptor type I (IP3R1) also significantly increased cone density in the CNG-channel-deficient mice, suggesting that IP3R1 signaling contributes to Ca(2+) homeostasis and cone survival. PMID: 28495882
6. Pathological mutations of ITPR1 (inositol 1,4,5-trisphosphate receptor, type 1) were found in seven patients from four families all localized in the IRBIT (inositol triphosphate receptor binding protein) domain. PMID: 27062503
7. The results suggest that IP3R1 and IP3R3 are required for extra-embryonic vascularization in the placenta, allantois, and yolk sac. PMID: 27514653
8. The results show that phosphorylations by Cdk1 and MAPK enhance the activity of IP3R1, which is consistent with its maximal activity observed at the time of fertilization and the role of Ca(2+) release in egg activation. PMID: 26259730
9. data indicate that PTPalpha and FAK, which are enriched in FAs, interact with IP3R1 at adjacent ER sites to spatially sequester IL-1-induced Ca(2+) signalling PMID: 26611753
10. IGF-1 strengthens the interaction between NCS-1 and IP3R in the process of regulation of nuclear Ca2+ signaling in cardiomyocytes. PMID: 25897502
11. Car8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway. PMID: 25734498
12. cGMP/protein kinase G signaling suppresses Itpr1 phosphorylation and promotes endoplasmic reticulum stress in photoreceptors of Cnga3-deficient mice. PMID: 26124274
13. Association of SLAT with IP receptor 1 promotes Ca(2) signaling in T cells. PMID: 25270259
14. IP3R-mediated Ca2+ signaling reinforces Tcf-1 activity to both ensure normal development and to prevent thymocyte neoplasia. PMID: 25215520
15. reduced retinal DA metabolism/turnover may be associated with increased susceptibility to myopia in mice with ON pathway defect mutations. PMID: 26072023
16. These results demonstrated, for the first time, that IP3R physically interacts with Cx43 and participates in the regulation of Cx43 phosphorylation on S279/282, thereby affecting GJ intercellular communication in ventricular myocytes PMID: 25262337
17. DISC1 binds ITPR1 mRNA with HZF, thereby regulating its dendritic transport for synaptic plasticity. PMID: 25821909
18. Ca(2+)-mediated cell death signaling between the IRE1alpha-InsP3R pathway in the endoplasmic reticulum, is reported. PMID: 24743743
19. By upholding myosin II activity, constitutive calcium release from the endoplasmic reticulum through IPR1 maintains dendritic cell polarity during migration. PMID: 25637353
20. IP3R palmitoylation is a critical regulator of Ca(2+) flux in immune cells and a previously unidentified DHHC/Selk complex is responsible for this process. PMID: 25368151
21. These data showed that loss of dystrophin in mdx cardiomyocytes produced an age-dependent intracellular Ca(2+) and Na(+) overload mediated at least in part by enhanced Ca(2+) receptor potential channels (TRPC), and by IP3 receptors. PMID: 25242522
22. This study supports a role for caspase 3 cleaved IP3 R1 and C terminal-IP3 R1 in regulating Ca(2+) homeostasis and the endoplasmic reticulum Ca(2+) content during oocyte maturation. PMID: 24692207
23. Genetic reduction of the type 1 inositol trisphosphate receptor by 50% normalized exaggerated Ca(2+) signaling observed in cortical and hippocampal neurons in animal models of Alzheimer disease. PMID: 24828645
24. These findings implicate IP3R1-dependent Purkinje cell firing patterns in cerebellum in motor coordination and the expression of dystonia through the olivo-cerebellar pathway. PMID: 24109434
25. IP3R up-regulation in VSM is associated with enhancement and sensitization of IP3-dependent Ca(2+) release, resulting in increased VSM contraction in response to agonist stimulation. PMID: 24097979
26. Data suggest that expression of Itpr1 in cerebral cortex neurons is regulated by dopamine D2 receptors; Itpr1 is up-regulated via increased binding of transcription factor AP-1 and nuclear factor of activated T cells 4 to Itpr1 promoter region. PMID: 23597509
27. Our findings reveal a specific role for IP3R1 in Purkinje cells not only as an intracellular mediator of cerebellar synaptic plasticity induction, but also as a critical regulator of PF-PC synaptic circuit maintenance in the mature cerebellum PMID: 23884927
28. Postsynaptic IP3R1 activity regulates synaptic gene expression and neuromuscular transmission PMID: 22418950
29. we propose a novel regulatory mechanism of IP3R1 activity by type III intermediate filament vimentin PMID: 22929228
30. novel insights regarding the regulation of IP3R1 during proteolysis and provide direct evidence that polypeptide continuity is not required for IP3R activation and Ca(2+) release. PMID: 23479737
31. mGluR5 induces facilitation of the depolarization-evoked calcium current via a functional coupling of mGluR5, InsP3R, and L-type voltage-dependent calcium channels PMID: 22586220
32. KRAP physically interacts with IP3R1 receptors in the kidney and IP3R3 receptors in the stomach. PMID: 22992961
33. IP(3)-Ca(2+) signaling in astrocytes is not only critical for P2Y(1)R-enhanced protection, but suggest that IP(3)-Ca(2+) signaling is also a key component of endogenous neuroprotection. PMID: 23321785
34. membrane-delimited signaling involving cross-talk between IP(3)R1 and RyR1 contributes to Ca(2+) spark activation in skeletal muscle PMID: 23223241
35. IP(3)R harbors two different binding sites for anti-apoptotic Bcl-2 proteins, one in the central, modulatory domain and one in the C-terminal domain near the Ca(2+)-channel pore. PMID: 23058917
36. TNF-alpha promotes RANKL-induced osteoclastogenesis, at least partially, through PC-PLC/IP3R1/NFATc1 pathway. PMID: 22819818
37. We determined that recombinant 5PP overexpression alleviated age-dependent dysfunction in the firing pattern of SCA2 PCs. PMID: 22973002
38. InsP(3) receptors mediate Ca(2+)-induced Ca(2+) release in OECs, and that this Ca(2+) release is temperature-sensitive and can be suppressed at temperatures above 28 degrees C. PMID: 22633850
39. IP3R-1 intracellular signaling pathway mediates development of cocaine-induced place preference and is controlled by dopamine D1 and D2 receptors in the frontal cortex and nucleus accumbens of mice with cocaine-induced place preference. PMID: 22033896
40. A single amino-acid difference between BH4-Bcl-2 and BH4-Bcl-Xl therefore underlies differential regulation of IP(3)Rs and Ca(2 )-driven apoptosis. PMID: 21818117
41. The results suggest that the regulation of calcium in the endoplasmic reticulum and IP(3)R1 phosphorylation during maturation enhance IP(3)R1 sensitivity rendering oocytes competent to initiate oscillations at the expected time of fertilization. PMID: 21465476
42. IP3R1 antagonism in this study had a effect at reducing pathologic changes and protecting the NMJ in two conditions of cholinergic excess, suggested that Skeletal muscle IP3R1 receptors play important role in synaptic calcium signals. PMID: 22031873
43. Conformational changes in IP(3)R evoked by various concentrations of ligands by using the fluorescence resonance energy transfer between two fluorescent proteins, were studied. PMID: 21876165
44. These results demonstrate that the Ca(2+) release properties of IP(3)R1 are largely unaffected by the P1059L mutation. PMID: 21689634
45. uncovers a novel role of IP3R1 in regulation of in vivo glucose homeostasis and development of diet-induced diabetes. PMID: 21565852
46. IP3R1 and 3 are genetically redundant and essential for cardiovascular development; redundant roles of IP3R1 and 3 may be implicated in regulation of cell death and the Mef2c-Smyd1 transcriptional cascade during development of the second heart field PMID: 21382375
47. KRAP is involved in the proper regulation of IP3R-mediated Ca2+ release. PMID: 21457704
48. Expression levels of the two main receptor isoforms IP3R1 and IP3R3 in embryonic fibroblasts are not significantly affected by the absence of STIM1 and STIM2 proteins. PMID: 20801505
49. all IP(3)R types are subject to ubiquitination at approximately the same locations and that, independent of cell type, IP(3)Rs are modified by monoubiquitin and Lys-48- and Lys-63-linked ubiquitin chains, although in differing proportions PMID: 21071436
50. Gene knock-outs of ITPR1 and ITPR2 result in perturbation of cardiogenesis. PMID: 20824138

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KEGG: mmu:16438

STRING: 10090.ENSMUSP00000032192

UniGene: Mm.227912