Recombinant Mouse Interleukin-15 (Il15)

1. SINTBAD regulates IL-15-induced autophagy and NKT cell survival. PMID: 30022064
2. this study shows that IL-15 supports the generation of protective lung-resident memory CD4 T cells PMID: 29186108
3. The small intestinal lamina propria innate lymphoid cells subset are not completely IL-7R dependent, but can persist partially through IL-15 signalling. PMID: 28361874
4. IL-15, mainly produced by non-hematopoietic cells in lung tissue and being trans-presented, promoted inflationary T cell survival by increasing expression of Bcl-2 PMID: 29652930
5. This review provides significant characterization of specific systemic, cellular and molecular alterations caused by IL-15 superagonist treatment as compared to native IL-15 and compares their anti-tumor effectiveness in multiple preclinical studies [Review] PMID: 28888485
6. IL-15 trans-presentation by non-CD4 T cells is the primary mechanism via which IL-15 controls CD4 effector T cell differentiation. PMID: 28807496
7. the protective effect on metastasis was lost upon patrolling monocyte or NK cell depletion, IL15 neutralization, or IFNgamma ablation. The combined analysis of these approaches allowed us to establish a hierarchy in which patrolling monocytes, making IL15 in response to primary tumors, activate NK cells and IFNg production that then inhibit lung metastasis formation. PMID: 28811289
8. an IL-15 isoform lacking exon-6, IL-15DeltaE6, generated by alternative splicing events of activated immune cells, including macrophages and B cells, is reported. PMID: 27166125
9. IL-15, but not IL-15Ralpha, is required for the development of spontaneous and virus-induced Type 1 diabetes. PMID: 26853723
10. hetIL15 administration improves the outcome of Adoptive cell transfer in lymphoreplete hosts, a finding with significant implications for improving cell-based cancer immunotherapy strategies. PMID: 27986749
11. These data demonstrate that mice with an endogenous IL-15 deficiency are susceptible to the development of severe, enhanced Th2-mediated allergic airway disease, which can be regulated by CD8(+) T cells. PMID: 28093832
12. IL-15 induces the activation and survival of effector immune cells that are necessary for its antitumoral activity; but, long-term exposure to IL-15 is associated with the development of important side effects mainly mediated by IFN-gamma-producing T-cells PMID: 27356750
13. findings indicated that IL-15 plays an important role in preventing leukemia development. PMID: 26876593
14. NK cells activated by IL-4 in cooperation with IL-15 exhibit distinctive characteristics with enhanced immunologic cytotoxicity. PMID: 27551096
15. Genetic ablation of the IL2Rbeta chain on CD8(+) T cells restrains inhibitory receptor induction, in particular 2B4 and Tim-3; precludes terminal differentiation of highly defective PD-1(hi) effectors; and rescues memory T-cell development and responsiveness to IL-7-dependent signals. Together, we ascribe a previously unexpected role to IL-2 and IL-15 as instigators of CD8(+) T-cell exhaustion during chronic viral infe... PMID: 27573835
16. this study reveals the function of IL-15 in astrocyte survival via Akt phosphorylation in response to OGD-induced damage. PMID: 28110119
17. Our new compelling findings have established the critical roles of both IL-7 and IL-15 in the maintenance of memory Th17 cells, and the previously undescribed therapeutic advantages of targeting IL-7 and IL-15 further support a promising clinical translation in Th17 cell-mediated autoimmune and inflammatory disorders. PMID: 27899224
18. results show that IL-15 is implicated in the high fat diet-induced lipid accumulation and inflammation in the liver, leading to fatty liver disease PMID: 26868085
19. homeostasis of IL-15-dependent lymphocyte subsets is also regulated by trans-presentation of IL-15 by non-hematopoietic cells in the tissue environment. PMID: 26778709
20. Recombinant IL-15 is a promising agent for cancer immunotherapy both in humans and animals. PMID: 28286036
21. Taken together, these data suggest that CCR7 biases memory CD8 T cells toward IL-7-dependent niches over IL-15-dependent niches, which provides insight into the homeostatic regulation of different memory T-cell subsets. PMID: 27385825
22. results demonstrate that IL-15 and RANKL induce osteoclastogenesis synergistically, and IL-15 might play a novel and major role in destructive inflammatory bone diseases PMID: 27608420
23. This study provides mechanistic insight into how IL-15 controls the generation of memory CD8 T cells and influences their trafficking and ability to take up residence within peripheral tissues. PMID: 28814601
24. findings extend understanding of the differential modes of action between IL-2 and IL-15, and highlight how, although sharing the CD122/CD132 receptor, they elicit such different immune actions PMID: 28507024
25. IL-15 induced by inflammatory signals in response to lymphodepletion drives lymphocyte responses, as memory CD8 T cells proliferated in an IL-15-dependent manner. PMID: 27183627
26. these findings unveil a role for IL-15 as a critical mediator in defense against systemic candidiasis and hold promise for the design of IL-15-based antifungal immunotherapies. PMID: 28636955
27. developmental arrest of Natural killer cells results from a lack of IL-15 availability in the microenvironment. PMID: 27837016
28. IL-15 impacts butyrate-producing bacteria and lowers butyrate levels in the absence of overt pathology, which represent events that precede and promote intestinal inflammatory diseases. PMID: 27648810
29. endogenous IL-15 does not directly augment the pathogenesis of sepsis but enables the development of septic shock by maintaining NK cell numbers and integrity. PMID: 28031340
30. this study shows that IL-15-mediated control of the precursor population affects the development of virus-specific CD8+ T-cell memory PMID: 27457412
31. this study shows that unleashed trans-presentation of IL-15 on MyD88-deficient fibroblastic reticular cells during viral infection fosters the activation of cytotoxic and non-cytotoxic group 1 innate lymphoid cells and accelerates clearance of the virus PMID: 27798617
32. this study shows that synergistic enhancement of adaptive immunity by the combination of epigallo catechin gallate and vitamin A or E is dependent on both IL-15 and its receptor PMID: 27135790
33. Under steady-state conditions, KLF2-deficient NK cells alter their expression of homeostatic homing receptors and subsequently undergo apoptosis due to IL-15 starvation. PMID: 27114551
34. The induction of IgM and IgA, which can play pivotal roles in mucosal immunity, was promoted in the presence of IL-15. Collectively, the data implicate IL-15 as the master cytokine that induces B-1a cells to mount a mucosal immune response. PMID: 25748019
35. The novel mechanism of IL-15 transfer to the surface of antigen-processing DCs may explain the enhanced potency of IL-15:IL-15Ralpha-coated nanoparticles for antigen delivery. PMID: 26719339
36. Muscle FNDC5 mRNA expression and irisin release are not IL-15-dependent in mice. PMID: 25920499
37. Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner. PMID: 27097762
38. Impaired delivery of IL-15 to CD4+ T cells in the colon downmodulates Foxp3 expression and enhances RORgammat expression. CD4+ T cells deprived of IL-15 trigger IBD characterized by production of pro-inflammatory cytokines and accumulation of Th1/Th17 cells. PMID: 26964669
39. Most (86%) IL15 in serum resides in the free state, with a minor proportion (14%) residing in complex with IL15Ralpha. Results suggest that IL15 is released as a free molecule by an unknown mechanism rather than via cleavage of membrane-bound IL15/IL15Ralpha. PMID: 26812159
40. IL-15 may influence mononuclear phagocytes subsets in the gut in a novel way that alters the frequency of lamina propria Th17 cells. PMID: 26600079
41. Downregulation of STAT3 phosphorylation enhances tumoricidal effect of IL-15-activated dendritic cell against doxorubicin-resistant lymphoma and leukemia via TNF-alpha. PMID: 26255115
42. Exercise-stimulated interleukin-15 is controlled by AMPK and regulates skin metabolism and aging. PMID: 25902870
43. IL-15 specifically down-regulates RARB expression, and RARB may play a protective role in lung injury caused by smoking or viral infections. PMID: 25923039
44. Hair follicle expression of IL-15 was required for CD8+ skin-resident memory T (TRM) cells to exert tropism for the epidermis. PMID: 26479922
45. High levels of IL-15 can promote tumor destruction and reduce metastasis in breast cancer via effects on NK1.1 positive cells. PMID: 25879689
46. The role of the IL-15 receptor alpha in metabolism and obesity is reported. PMID: 26269523
47. We demonstrated that IL-15 has a role in mammary cancer immunosurveillance and that IL-15-regulated NK and CD8+ memory cells play a role in long-lasting immunoprevention PMID: 25997501
48. Type I interferon signaling is required for generating soluble IL-15 complexes. PMID: 25756182
49. data reveal that inflammatory IL-15 promotes optimal responses by memory CD8+ T cells. PMID: 26241055
50. IL-15 is involved in adipose tissue regulation and linked to altered mitochondrial function PMID: 25517731

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KEGG: mmu:16168

STRING: 10090.ENSMUSP00000034148

UniGene: Mm.4392