Function |
Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha. In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation.
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Gene References into Functions |
- SINTBAD regulates IL-15-induced autophagy and NKT cell survival. PMID:
30022064
- this study shows that IL-15 supports the generation of protective lung-resident memory CD4 T cells PMID:
29186108
- The small intestinal lamina propria innate lymphoid cells subset are not completely IL-7R dependent, but can persist partially through IL-15 signalling. PMID:
28361874
- IL-15, mainly produced by non-hematopoietic cells in lung tissue and being trans-presented, promoted inflationary T cell survival by increasing expression of Bcl-2 PMID:
29652930
- This review provides significant characterization of specific systemic, cellular and molecular alterations caused by IL-15 superagonist treatment as compared to native IL-15 and compares their anti-tumor effectiveness in multiple preclinical studies [Review] PMID:
28888485
- IL-15 trans-presentation by non-CD4 T cells is the primary mechanism via which IL-15 controls CD4 effector T cell differentiation. PMID:
28807496
- the protective effect on metastasis was lost upon patrolling monocyte or NK cell depletion, IL15 neutralization, or IFNgamma ablation. The combined analysis of these approaches allowed us to establish a hierarchy in which patrolling monocytes, making IL15 in response to primary tumors, activate NK cells and IFNg production that then inhibit lung metastasis formation. PMID:
28811289
- an IL-15 isoform lacking exon-6, IL-15DeltaE6, generated by alternative splicing events of activated immune cells, including macrophages and B cells, is reported. PMID:
27166125
- IL-15, but not IL-15Ralpha, is required for the development of spontaneous and virus-induced Type 1 diabetes. PMID:
26853723
- hetIL15 administration improves the outcome of Adoptive cell transfer in lymphoreplete hosts, a finding with significant implications for improving cell-based cancer immunotherapy strategies. PMID:
27986749
- These data demonstrate that mice with an endogenous IL-15 deficiency are susceptible to the development of severe, enhanced Th2-mediated allergic airway disease, which can be regulated by CD8(+) T cells. PMID:
28093832
- IL-15 induces the activation and survival of effector immune cells that are necessary for its antitumoral activity; but, long-term exposure to IL-15 is associated with the development of important side effects mainly mediated by IFN-gamma-producing T-cells PMID:
27356750
- findings indicated that IL-15 plays an important role in preventing leukemia development. PMID:
26876593
- NK cells activated by IL-4 in cooperation with IL-15 exhibit distinctive characteristics with enhanced immunologic cytotoxicity. PMID:
27551096
- Genetic ablation of the IL2Rbeta chain on CD8(+) T cells restrains inhibitory receptor induction, in particular 2B4 and Tim-3; precludes terminal differentiation of highly defective PD-1(hi) effectors; and rescues memory T-cell development and responsiveness to IL-7-dependent signals. Together, we ascribe a previously unexpected role to IL-2 and IL-15 as instigators of CD8(+) T-cell exhaustion during chronic viral infe... PMID:
27573835
- this study reveals the function of IL-15 in astrocyte survival via Akt phosphorylation in response to OGD-induced damage. PMID:
28110119
- Our new compelling findings have established the critical roles of both IL-7 and IL-15 in the maintenance of memory Th17 cells, and the previously undescribed therapeutic advantages of targeting IL-7 and IL-15 further support a promising clinical translation in Th17 cell-mediated autoimmune and inflammatory disorders. PMID:
27899224
- results show that IL-15 is implicated in the high fat diet-induced lipid accumulation and inflammation in the liver, leading to fatty liver disease PMID:
26868085
- homeostasis of IL-15-dependent lymphocyte subsets is also regulated by trans-presentation of IL-15 by non-hematopoietic cells in the tissue environment. PMID:
26778709
- Recombinant IL-15 is a promising agent for cancer immunotherapy both in humans and animals. PMID:
28286036
- Taken together, these data suggest that CCR7 biases memory CD8 T cells toward IL-7-dependent niches over IL-15-dependent niches, which provides insight into the homeostatic regulation of different memory T-cell subsets. PMID:
27385825
- results demonstrate that IL-15 and RANKL induce osteoclastogenesis synergistically, and IL-15 might play a novel and major role in destructive inflammatory bone diseases PMID:
27608420
- This study provides mechanistic insight into how IL-15 controls the generation of memory CD8 T cells and influences their trafficking and ability to take up residence within peripheral tissues. PMID:
28814601
- findings extend understanding of the differential modes of action between IL-2 and IL-15, and highlight how, although sharing the CD122/CD132 receptor, they elicit such different immune actions PMID:
28507024
- IL-15 induced by inflammatory signals in response to lymphodepletion drives lymphocyte responses, as memory CD8 T cells proliferated in an IL-15-dependent manner. PMID:
27183627
- these findings unveil a role for IL-15 as a critical mediator in defense against systemic candidiasis and hold promise for the design of IL-15-based antifungal immunotherapies. PMID:
28636955
- developmental arrest of Natural killer cells results from a lack of IL-15 availability in the microenvironment. PMID:
27837016
- IL-15 impacts butyrate-producing bacteria and lowers butyrate levels in the absence of overt pathology, which represent events that precede and promote intestinal inflammatory diseases. PMID:
27648810
- endogenous IL-15 does not directly augment the pathogenesis of sepsis but enables the development of septic shock by maintaining NK cell numbers and integrity. PMID:
28031340
- this study shows that IL-15-mediated control of the precursor population affects the development of virus-specific CD8+ T-cell memory PMID:
27457412
- this study shows that unleashed trans-presentation of IL-15 on MyD88-deficient fibroblastic reticular cells during viral infection fosters the activation of cytotoxic and non-cytotoxic group 1 innate lymphoid cells and accelerates clearance of the virus PMID:
27798617
- this study shows that synergistic enhancement of adaptive immunity by the combination of epigallo catechin gallate and vitamin A or E is dependent on both IL-15 and its receptor PMID:
27135790
- Under steady-state conditions, KLF2-deficient NK cells alter their expression of homeostatic homing receptors and subsequently undergo apoptosis due to IL-15 starvation. PMID:
27114551
- The induction of IgM and IgA, which can play pivotal roles in mucosal immunity, was promoted in the presence of IL-15. Collectively, the data implicate IL-15 as the master cytokine that induces B-1a cells to mount a mucosal immune response. PMID:
25748019
- The novel mechanism of IL-15 transfer to the surface of antigen-processing DCs may explain the enhanced potency of IL-15:IL-15Ralpha-coated nanoparticles for antigen delivery. PMID:
26719339
- Muscle FNDC5 mRNA expression and irisin release are not IL-15-dependent in mice. PMID:
25920499
- Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner. PMID:
27097762
- Impaired delivery of IL-15 to CD4+ T cells in the colon downmodulates Foxp3 expression and enhances RORgammat expression. CD4+ T cells deprived of IL-15 trigger IBD characterized by production of pro-inflammatory cytokines and accumulation of Th1/Th17 cells. PMID:
26964669
- Most (86%) IL15 in serum resides in the free state, with a minor proportion (14%) residing in complex with IL15Ralpha. Results suggest that IL15 is released as a free molecule by an unknown mechanism rather than via cleavage of membrane-bound IL15/IL15Ralpha. PMID:
26812159
- IL-15 may influence mononuclear phagocytes subsets in the gut in a novel way that alters the frequency of lamina propria Th17 cells. PMID:
26600079
- Downregulation of STAT3 phosphorylation enhances tumoricidal effect of IL-15-activated dendritic cell against doxorubicin-resistant lymphoma and leukemia via TNF-alpha. PMID:
26255115
- Exercise-stimulated interleukin-15 is controlled by AMPK and regulates skin metabolism and aging. PMID:
25902870
- IL-15 specifically down-regulates RARB expression, and RARB may play a protective role in lung injury caused by smoking or viral infections. PMID:
25923039
- Hair follicle expression of IL-15 was required for CD8+ skin-resident memory T (TRM) cells to exert tropism for the epidermis. PMID:
26479922
- High levels of IL-15 can promote tumor destruction and reduce metastasis in breast cancer via effects on NK1.1 positive cells. PMID:
25879689
- The role of the IL-15 receptor alpha in metabolism and obesity is reported. PMID:
26269523
- We demonstrated that IL-15 has a role in mammary cancer immunosurveillance and that IL-15-regulated NK and CD8+ memory cells play a role in long-lasting immunoprevention PMID:
25997501
- Type I interferon signaling is required for generating soluble IL-15 complexes. PMID:
25756182
- data reveal that inflammatory IL-15 promotes optimal responses by memory CD8+ T cells. PMID:
26241055
- IL-15 is involved in adipose tissue regulation and linked to altered mitochondrial function PMID:
25517731
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