Recombinant Mouse Interleukin-17 receptor A (Il17ra), partial

1. Study shows that miR-215 regulates the Act1/IL-17RA pathway and represses the expression of Act1 protein in oxygen glucose deprivation/reperfusion-treated N2a cells and an middle cerebral artery occlusion mouse model of ischemic stroke. PMID: 29080697
2. study provides insight regarding a novel antiviral role for IL-17A in the genital tract, in which IL-17A improves mucosal vaccination efficacy by mediating efficient Th1 cell immunity PMID: 28956763
3. This study describes a previously unappreciated protective role for IL-17RA signaling in regulation of the skin barrier and maintenance of skin immune homeostasis. PMID: 28615416
4. These data show that IL-17R signaling in the lung epithelium plays a critical role in establishing chemokine gradients that are essential for mucosal immunity against pulmonary bacterial pathogens. PMID: 27923703
5. Thus, oral epithelial cells dominantly control IL-17R-dependent responses to oropharyngeal candidiasis through regulation of BD3 expression. PMID: 27923704
6. this study showsthat the nature of the protective memory response depends closely on the route of infection and highlights the role of IFN-gamma-and IL-17RA-mediated responses in the control of mucosal infection by Brucella PMID: 27036913
7. IL-17RA contributes to experimental glomerulonephritis, with IL-17RA expression on both leukocytes and stromal cells being required for the full expression of nephritogenic humoral immunity. PMID: 27941331
8. genetic deletion results in earlier onset of experimental autoimmune encephalomyelitis and worsened disease severity PMID: 26982366
9. IL-17RA in non hematopoietic cells regulates recruitment of neutrophils to the lung during the adaptive phase of the immune response. PMID: 26871571
10. IL-17 signaling through IL-17RA is an important driver of lung inflammation and airway hyperresponsiveness. PMID: 25919006
11. results suggest that the p38alpha-MKP-1 signaling axis links IL-17R signaling in tissue-resident cells to autoimmune inflammation dependent on infiltrating T(H)17 cells. PMID: 25737586
12. There were no significant differences in clinical scores and numbers of infiltrating eosinophils among IL-25KO, TSLPR KO, and wild-type mice. PMID: 26244295
13. promotes colorectal tumorigenesis in transformed enterocytes PMID: 25526314
14. IL-17RA signaling is critical for the development of renal pathology in autoimmune glomerulonephritis.IL-17 enhanced the production of proinflammatory cytokines and chemokines from tubular epithelial cells. PMID: 24935958
15. Il17ra appears to be a novel modulator of monocyte phenotype and possible therapeutic target in renal fibrosis PMID: 24454873
16. IL-17 expression is higher in C57BL/6 versus BALB/c cornea after infection and that the latter group has more MerTK+ cells. PMID: 25298414
17. It was concluded that TLR signaling can directly stimulate the expression of IL-17RA, but not IL-17RC, in neuroglial cells, which functionally respond to IL-17A by secreting chemokines, and accelerating CD4 cell migration. PMID: 25076485
18. Absence of IL-17RA leads to a Th2-like phenotype characterized by IL-4 production and suggests that IL-17RA signaling plays a critical role in the regulation of IL-4 in collagen-induced arthritis and development of autoimmune inflammation of the joint. PMID: 24504806
19. IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells. PMID: 23858031
20. IL-17RA KO mice have a failure of resolution of inflammation. IL-17RA protects against infection-induced periapical inflammation & bone destruction via suppression of neutrophil & mononuclear inflammation. PMID: 23863904
21. IL-17A receptor signaling regulates bacterial clearance as well as natural killer T (NKT) cell and gammadelta T cell infiltrates during Staphylococcus aureus-induced brain abscess formation. PMID: 22704602
22. These data demonstrate PI3Kgamma-dependent signalling downstream of IL-17RA, which plays a pivotal role in regulating IL-17 production in T cells. PMID: 22930133
23. IL-17RA signaling modulates IFN-gamma-mediated inflammatory responses during infections and recruitment of suppressive IL-10-producing neutrophils. PMID: 22577359
24. Data show that deletion of the CC' loop from Act1 or IL-17RA abolished the interaction between both proteins. PMID: 22045852
25. IL-17RA signaling plays a role as an amplifier of the effector phase of inflammatory arthritis PMID: 22028860
26. mRNA levels of IL-17, IL-17R and MMP-9 were also higher in the invasive group than in the non-invasive group in human pituitary adenomas. PMID: 21279695
27. TRAF3 is a negative regulator of IL-17R proximal signaling. PMID: 21078888
28. an extended SEFIR domain is required for il-17RA-mediated signal transduction. PMID: 20729198
29. Oral Toxoplasma gondii infection increases IL-17 expression via IL17RA and contributes to the inflammatory response, and IL-17 neutralization has a partial protective effect against fatal Toxoplasma gondii-associated inflammation. PMID: 20575661
30. mouse IL-17Receptor may belong to a novel growth-receptor like molecule that has the capability to support cellular mitogenesis through RAS/MAPK pathway. PMID: 16310341
31. In the absence of ligand, IL-17RA molecules exhibited significant specific FRET efficiency, demonstrating that they exist in a multimeric, preformed receptor complex. PMID: 16393951
32. The biologic activity of IL-17 is dependent on a complex composed of receptors IL-17RA and IL-17RC. PMID: 16785495
33. structure-function analysis of a IL-17 superfamily receptor reveals important differences in IL-17RA compared with IL-1/TLR receptors PMID: 17456598
34. This study demonstrates a gender-dependent effect of IL-17 signaling and indicates that gender differences should be taken into account in the preclinical and clinical safety testing of anti-IL-17 biologic therapies. PMID: 18591228
35. IL-17A controls the expansion of IL-17A-producing neutrophil-regulatory T cell populations through IL-17R PMID: 18606690
36. IL-17F/IL-17R interaction stimulates granulopoiesis in mice. PMID: 18723265
37. IL-25-mediated activities require both IL-17RB and IL-17RA in this example of an IL-17 family ligand that utilizes a heteromeric receptor complex. PMID: 18768888
38. A role is supported for IL-17RA-independent mechanisms in the development of experimental autoimmune encephalomyelitis. PMID: 19234160
39. IL-17RA expression is significantly increased in the central nervous system of mice with experimental autoimmune encephalomyelitis compared to healthy mice PMID: 19400960
40. our data suggest an important role for IL-17A-expressing T lymphocytes in eliminating Bacillus subtilis PMID: 19414809
41. IL-17R-deficient mice, subjected to cecal ligation and puncture-induced non-severe sepsis PMID: 19494309
42. signaling via the IL-17 receptor in bone marrow derived cells enhances the process of atherosclerosis. PMID: 19660432
43. In contrast to many chronic inflammatory diseases in which IL-17RA signaling promotes an inflammatory response, IL-17RA signaling down-regulates the chronic mononuclear inflammation elicited by Helicobacter pylori infection. PMID: 19812196

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KEGG: mmu:16172

STRING: 10090.ENSMUSP00000002976

UniGene: Mm.4481