Recombinant Mouse Interleukin-2 receptor subunit alpha (Il2ra), partial (Active)

1. Analyze the percentage of CD4(+)CD25(-)T cells. PMID: 28810531
2. Results indicate that conjugated-interleukin-2 (IL2) protein derived from NKTR-214 occupy interleukin-2 (IL2) receptor complex (IL2Ralphabetagamma) to a greater extent compared to free-IL2 protein. PMID: 28678791
3. CDK6-mediated suppression of CD25 is required for initiation of T-ALL by activated Notch1. . Pharmacologic inhibition of CDK6 kinase induces CD25 and RUNX1 expression, cell cycle arrest and apoptosis in mouse and human T-ALL. PMID: 26707936
4. murine podocytes express the IL-2R, and activation through the IL-2R results in podocyte injury PMID: 27389192
5. Combination with anti-programmed cell death protein-1 (PD-1) antibodies promoted complete tumor rejection, indicating the relevance of CD25 antigen as a therapeutic target and promising substrate for future combination approaches in immune-oncology. PMID: 28410988
6. Intratesticular inoculation with donor antigens promotes long-term skin allograft survival induced by conventional costimulatory blockade via the induction of both CD8 + CD122+ and CD4 + CD25+ Treg cells. PMID: 26569069
7. Expansion of CD25-expressing innate lymhpoid cells by IL-2/anti-IL-2 complexes leads to a reduction in very low-density lipoprotein cholesterol and atherosclerosis. PMID: 26494229
8. our results identify IL-7 as a necessary factor contributing to sustained CD25 expression at Treg surface in vivo thereby affecting their ability to efficiently react to IL-2. PMID: 25485946
9. Data indicate that the deletion of interferon-gamma (IFN-gamma) in the CD25 knockout (KO) mice delays glandular destruction and preserves glandular function. PMID: 23116218
10. Functional NK cell repertoires are maintained through IL-2Ralpha and Fas ligand. PMID: 24634493
11. Ag-dependent signals activated low IL-2Ralpha & high IL-2 production, independent of IL-2 signaling. Later, secreted IL-2 acted as a shared resource driving high IL-2Ralpha expression. PMID: 24244020
12. Therefore, EXOs derived from natural CD4(+)25(+) and CD8(+)25(+) Tr cells may become an alternative for immunotherapy of autoimmune diseases. PMID: 23876314
13. Infections with murine cytomegalovirus, but not with lymphocytic choriomeningitis virus, induce CD25 on natural killer (NK) cells, along with high levels of interleukin (IL)-12. PMID: 22888135
14. Hepatic stellate cells seem to act as liver-resident antigen-presenting cells instructing the generation of CD4/CD25/Foxp3(+) regulatory T cells. PMID: 22564624
15. Ablation of the CD25+ dendritic cell subset accounts for decreased activation and expansion of gammadelta T cells, leading to decreased activation of IL-17-positive interphotoreceptor retinoid-binding protein-specific T cells. PMID: 22539790
16. leflunomide has an effect on CD4(+)CD25 (+)Foxp3 (+) T regulatory cells in mice receiving allogeneic bone marrow transplantation PMID: 22057872
17. Dexamethasone could promote the expression of CD25 and FOXP3 in the mouse asthma model. PMID: 21265093
18. HMGB1 has the ability to directly modulate the suppressive capacity of CD4(+)CD25(+)Tregs, and TLR4 might be a potential receptor essential for the negative effect of HMGB1 on CD4(+)CD25(+)Tregs activity PMID: 21419643
19. All mice given presensitized CD25-depleted T cells survived a tumor rechallenge, indicating the development of long-term CD8 T-cell memory to tumor antigens. PMID: 21521781
20. Data show that CD8(+) T cell tolerance established in the lung depends only partially on the function of CD4+CD25+Foxp3+ regulatory T cells. PMID: 21518973
21. Prolonged survival of allografts induced by mycobacterial Hsp70 is dependent on CD4+CD25+ regulatory T cells PMID: 21170379
22. CD25-expressing activated CD4 cells actively participate in maintaining self-tolerance in the periphery; abnormality of this T cell- mediated immunoregulation can be a common mechanism of various autoimmune diseases. PMID: 21422251
23. correspond to a discrete innate lymphoid cell population expressing CD25, CCR6 and IL-7R PMID: 21400499
24. Astragalus membranaceus injection prolonged allograft survival associated with promotion of CD4+ CD25+ Treg activities. PMID: 21094858
25. Results suggest that CD4+CD25+ Treg cells directly affect cisplatin nephrotoxicity and their modulation represents an additional treatment strategy. PMID: 20463654
26. Data show that the autoimmune exocrinopathy of the CD25KO LG is composed of a dynamic Th-1 and Th-17 response, with a Th-17 phenotype in young mice shifting to a Th-1-predominant expression at later time points. PMID: 20566743
27. Data show that CD4(+)IFN-gamma(high)IL-4(low)IL-10(low)TGF-beta(low)FOXp3(-) cells function as antigen-specific regulatory cells that restrain the development of autoimmunity by increasing the threshold of Th17 activation. PMID: 20382706
28. Transforming growth factor beta and CD25 are important for controlling systemic dissemination following Yersinia enterocolitica infection of the gut. PMID: 20584975
29. Immunosuppressive agents could be successfully combined with in vitro-expanded CD4+CD25+Foxp3+Treg cell therapy to prevent allograft rejection. PMID: 20305583
30. prolonged IL-2 signals during priming promote terminal-effector differentiation. PMID: 20096608
31. Flt3-L significantly inhibited the effect of cockroach antigen sensitization and challenge to increase GATA3 expression in lung CD4(+)CD25(+) T cells. PMID: 19448155
32. These results indicate that CD4+CD25+Foxp3+ Tregs modify innate immune responses during resolution of lung injury and suggest potential targets for treating acute lung injury. PMID: 19770521
33. Glutamic acid decarboxylase-derived epitopes with specific domains expand CD4(+)CD25(+) regulatory T cells PMID: 19759824
34. structural changes within the proximal downregulation of gene expression: structural changes within the enhancer/core promoter during T-cell development PMID: 11972331
35. data indicate an important role for both AP-1 and NFAT proteins for TCR-induced IL-2Ralpha expression and establish that both upstream and intronic sequences mediate TCR responsiveness of the IL-2Ralpha gene PMID: 12065418
36. important role of the interleukin-2 receptor beta chain region between the two Stat5 docking sites in induction of interleukin-2 receptor alpha PMID: 12231477
37. CD25 has a role in c-maf promotion of Th2 cytokine production PMID: 12271139
38. IL2-R alpha/IL-2 signals are not involved in control of bystander activation, but are instead required for the generation and peripheral expansion and survival of a population of regulatory CD4 T cells essential for peripheral CD4 T cell homeostasis. PMID: 12391195
39. A TGF-beta-dependent regulatory CD4+ T cell has been identified in an in vivo colitis model that is CD25 negative and latency-associated peptide (LAP) positive. PMID: 12594277
40. chromatin remodeling of the CD25 locus requires STAT4 and IL-12 PMID: 14660657
41. functional impairment of the CD4+ CD25+ regulatory T cells in STAT1-deficient animals PMID: 14699080
42. The T cells exclusively originating from preexisting CD4CD25 regulatory T cells and proves anergic and highly suppressive on isolation. PMID: 15665762
43. Results suggest that the suppression of myasthenia gravis-associated T cell responses exerted by the dual altered peptide ligand is mediated by the CD4+CD25+ immunoregulatory T cell function. PMID: 15677327
44. T cells in Peyer patches acquire a similar phenotype to CD4(+) CD25(+) regulatory T cells. PMID: 15681783
45. self-antigens that elicit naturally occurring CD4(+) CD25(+) T reg cells PMID: 15753203
46. CD4(+)CD25(+) regulatory T cells develop normally in the absence of TGF-beta1 and retain the ability to suppress colitis in vivo PMID: 15753207
47. Addition to bone-marrow cultures led to generation of dendritic cells that induced a CD4+CD25+) population inhibiting mixed leukocyte culture. PMID: 15880066
48. CD4+CD25+ regulatory T cells generated by immunization with these self-antigens enhance susceptibility to 3-methylcholanthrene induced-tumorigenesis by down-regulating iNK T and NK reactivity PMID: 15961541
49. A CD4+CD25+ regulatory T cell-based mechanism supports the abnormal immune system biology observed in IL-2 receptor alpha knockout mice PMID: 16034141
50. identifies a novel positive regulatory region in the IL-2Ralpha gene that mediates TGF-beta-dependent induction of the gene; findings have implications related to IL-2Ralpha expression on activated T cells and regulatory T cells PMID: 16087671

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KEGG: mmu:16184

STRING: 10090.ENSMUSP00000028111

UniGene: Mm.915