IL2RA (Interleukin-2 Receptor Alpha), also known as CD25 (Cluster of Differentiation 25), is a cell surface receptor belonging to the interleukin-2 (IL-2) receptor family. It serves as the α subunit of the IL-2 receptor and is widely expressed on the surface of immune cells, particularly in T lymphocytes (T cells). High expression of IL2RA is closely associated with the activated state of T cells, serving as a critical marker of T cell response. IL2RA plays a significant role in regulating immune responses and balancing T cell functions. IL2RA is pivotal in modulating immune responses and maintaining T cell functional equilibrium. Aberrant expression of IL2RA is implicated in certain immune disorders and autoimmune diseases, potentially leading to immune dysregulation and disease onset. Therefore, IL2RA is considered an important target for immunotherapy. By manipulating the function of IL2RA, it is possible to regulate T cell activation and function, making it a crucial player in immune-based therapies.
● IL2RA Recombinant Monoclonal Antibody CSB-RA011649MA1HU
Validated Data
The Binding Activity of Human IL2RA with Anti-IL2RA Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA (CSB-MP011649HU3) at 2 μg/mL can bind Anti-IL2RA recombinant antibody , the EC50 is 2.463-3.353 ng/mL.
● Recombinant Human Interleukin-2 receptor subunit alpha(IL2RA),partial (Active) CSB-MP011649HU3
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Anti-IL2RA recombinant antibody (CSB-RA011649MA1HU),the EC50 is 2.463-3.353 ng/mL.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bindHuman IL2(CSB-MP011629HU),the EC50 is 1.693-2.039 ng/mL.
The following IL2RA reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
IL2RA Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-MA000266 | IL2RA Monoclonal Antibody | Human | ELISA,IHC |
CSB-PA005198 | IL2RA Antibody | Human | WB, ELISA |
CSB-PA009542 | Phospho-IL2RA (S268) Antibody | Human | WB, IHC, IF, ELISA |
CSB-PA009543 | IL2RA Antibody | Human | WB, IF, ELISA |
CSB-PA904921 | IL2RA Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA013952 | IL2RA Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA011649LA01HU | IL2RA Antibody | Human, Rat | ELISA, WB, IHC, IF |
CSB-PA011649LC01HU | IL2RA Antibody, FITC conjugated | Human | |
CSB-PA011649LD01HU | IL2RA Antibody, Biotin conjugated | Human | ELISA |
CSB-RA011649MA1HU | IL2RA Recombinant Monoclonal Antibody | Human | ELISA, IF |
IL2RA Proteins for Pan troglodytes (Chimpanzee)
Code | Product Name | Source |
---|---|---|
CSB-YP656443EQV CSB-EP656443EQV CSB-BP656443EQV CSB-MP656443EQV CSB-EP656443EQV-B |
Recombinant Pan troglodytes Interleukin-2 receptor subunit alpha (IL2RA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL2RA Proteins for Macaca mulatta (Rhesus macaque)
Code | Product Name | Source |
---|---|---|
CSB-YP689641MOW CSB-EP689641MOW CSB-BP689641MOW CSB-MP689641MOW CSB-EP689641MOW-B |
Recombinant Macaca mulatta Interleukin-2 receptor subunit alpha (IL2RA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL2RA Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-CF011649RA | Recombinant Rat Interleukin-2 receptor subunit alpha (Il2ra) | in vitro E.coli expression system |
CSB-YP011649RA1 CSB-EP011649RA1 CSB-BP011649RA1 CSB-MP011649RA1 CSB-EP011649RA1-B |
Recombinant Rat Interleukin-2 receptor subunit alpha (Il2ra), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL2RA Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF011649MO | Recombinant Mouse Interleukin-2 receptor subunit alpha (Il2ra) | in vitro E.coli expression system |
CSB-YP011649MO1 CSB-EP011649MO1 CSB-BP011649MO1 CSB-EP011649MO1-B |
Recombinant Mouse Interleukin-2 receptor subunit alpha (Il2ra), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
IL2RA Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Source |
---|---|---|
CSB-CF011649DO | Recombinant Dog Interleukin-2 receptor subunit alpha (IL2RA) | in vitro E.coli expression system |
CSB-YP011649DO1 CSB-EP011649DO1 CSB-BP011649DO1 CSB-MP011649DO1 CSB-EP011649DO1-B |
Recombinant Dog Interleukin-2 receptor subunit alpha (IL2RA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL2RA Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-CF011649PI | Recombinant Pig Interleukin-2 receptor subunit alpha (IL2RA) | in vitro E.coli expression system |
CSB-YP011649PI1 CSB-BP011649PI1 CSB-MP011649PI1 CSB-EP011649PI1-B |
Recombinant Pig Interleukin-2 receptor subunit alpha (IL2RA), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL2RA Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF011649HU | Recombinant Human Interleukin-2 receptor subunit alpha (IL2RA) | in vitro E.coli expression system |
CSB-YP011649HU1 CSB-EP011649HU1 CSB-BP011649HU1 CSB-MP011649HU1 CSB-EP011649HU1-B |
Recombinant Human Interleukin-2 receptor subunit alpha (IL2RA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP011649HU2 | Recombinant Human Interleukin-2 receptor subunit alpha (IL2RA), partial | E.coli |
CSB-MP011649HU3 | Recombinant Human Interleukin-2 receptor subunit alpha (IL2RA), partial (Active) | Mammalian cell |
IL2RA Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-CF011649BO | Recombinant Bovine Interleukin-2 receptor subunit alpha (IL2RA) | in vitro E.coli expression system |
CSB-YP011649BO1 CSB-EP011649BO1 CSB-BP011649BO1 CSB-MP011649BO1 CSB-EP011649BO1-B |
Recombinant Bovine Interleukin-2 receptor subunit alpha (IL2RA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL2RA Proteins for Ovis aries (Sheep)
Code | Product Name | Source |
---|---|---|
CSB-CF011649SH | Recombinant Sheep Interleukin-2 receptor subunit alpha (IL2RA) | in vitro E.coli expression system |
CSB-YP011649SH1 CSB-EP011649SH1 CSB-BP011649SH1 CSB-MP011649SH1 CSB-EP011649SH1-B |
Recombinant Sheep Interleukin-2 receptor subunit alpha (IL2RA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL2RA Proteins for Felis catus (Cat) (Felis silvestris catus)
Code | Product Name | Source |
---|---|---|
CSB-CF011649CA | Recombinant Cat Interleukin-2 receptor subunit alpha (IL2RA) | in vitro E.coli expression system |
CSB-YP011649CA1 CSB-EP011649CA1 CSB-BP011649CA1 CSB-MP011649CA1 CSB-EP011649CA1-B |
Recombinant Cat Interleukin-2 receptor subunit alpha (IL2RA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL2RA ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04629h | Human soluble interleukin-2 receptor,IL-2sRα ELISA kit | serum, plasma, tissue homogenates | 19.5 pg/mL |
IL2RA ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E07440m | Mouse soluble interleukin-2 receptor,sIL-2Rα ELISA kit | serum, plasma, tissue homogenates | 3.9 pg/ml |